Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 31, 2024
Treatment of peripheral nerve defects is a major concern in regenerative medicine. This study therefore aimed to explore the efficacy neural graft constructed using adipose mesenchymal stem cells (ADSC), acellular microtissues (MTs), and chitosan treatment defects.
Language: Английский
Polymer Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 65
Published: Nov. 20, 2024
The biomedical industry has witnessed a transformative evolution with the advent of 3D printing technology. However, inherent limitations, such as inability to produce dynamic human tissues due absence temporal dimension, have persisted, resulting in static and inanimate printed products. To address this challenge enable creation living constructs, concept 4D emerged, marking paradigm shift additive manufacturing. In printing, time becomes fourth breathing life into previously creations. This review paper explores journey from pivotal role manufacturing process. Specifically, it highlights integration time-dependent responsive materials, focusing on stimuli-responsive hydrogels, cornerstone advancements. These materials exhibit remarkable ability adapt respond various stimuli, encompassing physical, chemical, biological signals. delves recent publications synergy between these stimuli shedding light their intricate interactions potential applications. One primary areas interest lies medical applications, notably tissue engineering, where holds immense promise. utilization creating biomimetic scaffolds that can dynamically complex environments. Furthermore, discusses technical considerations prospects technology, emphasizing its revolutionize landscape. amalgamation opens new avenues for personalized medicine, localized drug delivery, regenerative therapies, bridging gap requirements modern healthcare. present offers complete examination evolution, challenges, paving way innovations field.
Language: Английский
Citations
6
Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 130, P. 6 - 12
Published: Feb. 24, 2025
This study investigates the role of collagen-based bio-scaffolds in bone tissue regeneration, focusing on their biodegradability, biocompatibility, and mechanical strength-key properties that influence efficacy promoting osteogenesis angiogenesis. Collagen's natural origin resemblance to extracellular matrix make it an ideal material for scaffolds can support guide healing. The bio-scaffolds' biodegradability ensures a controlled transition from synthetic tissue, minimizing long-term complications. Their high biocompatibility reduces immune responses, facilitating seamless integration. Mechanical strength is tailored provide initial stability degrade as new forms, balancing need with regeneration process. Applications facial reconstruction, spinal fusion, long repair demonstrate versatility these scaffolds. Challenges such cost-effective production scaffold optimization specific applications remain. Future research will address fully harness potential revolutionizing strategies.
Language: Английский
Citations
0
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103477 - 103477
Published: March 1, 2025
Language: Английский
Citations
0
JPRAS Open, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Several traditional dressings may have limitation in treating wounds. A novel chitosan-based dressing designed for improved hemostasis, moisture, and sealing shows promise wound healing. However, its efficacy safety are yet to be sufficiently verified patients. This randomized controlled trial enrolled 40 patients suffering from acute skin wounds the limbs 12/2022 12/2023. They were randomly divided into two groups (20 vs. 20) received regular treatments Shenzhen Second People's Hospital. The experimental group was treated with liquid dressing, whereas control recombinant human epidermal growth factor (rhEGF). therapeutic effects (scar area pigment deposition), adverse events, visual analogue scale (VAS), healing time, cost, patient observer scar assessment (POSAS) evaluated on days 0, 7, 14, 28. No events observed throughout trial. On day 28, effective rate between not statistically significant (70% 85%, p = 0.256). Other parameters that included VAS (5.10 ± 1.62 6.35 2.39, 0.06), time (8.45 4.26 8.60 5.44 days, 0.923), cost (49.00 22.48 57.40 27.59, 0.298). patient- observer-reported SAS of chitosan (CS) significantly lower than rhEGF (12.00 9.50, z 2.477, 0.013; 18.50 12.50, 2.209, 0.026; respectively), total POSAS (30.50 22.00, 2.374, 0.017). Compared rhEGF, CS-based showed reliable equivalent performance limb wounds, as revealed by improvements rate, pain relief, costs. Moreover, reduced formation, indicating potential therapy.
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 12, 2025
Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. Intrinsic genetic factors extrinsic environmental cues regulate their differentiation into osteoblasts. Within the microenvironment, complex network of biochemical biomechanical signals orchestrates homeostasis regeneration. In addition, crosstalk among MSCs, immune cells, neighboring cells-mediated by extracellular vesicles non-coding RNAs (such as circular micro RNAs) -profoundly influences osteogenic Recent studies have explored specific signaling pathways that contribute to effective regeneration, highlighting potential manipulating microenvironment enhance MSC functionality. The integration advanced biomaterials, gene editing techniques, controlled delivery systems is paving way for more targeted efficient regenerative therapies. Furthermore, artificial intelligence could improve tissue engineering, optimize biomaterial design, enable personalized treatment strategies. This review explores latest advancements emphasizing intricate interplay molecules. By providing comprehensive overview these mechanisms clinical implications, we aim shed light on future research directions this rapidly evolving field.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101196 - 101196
Published: Aug. 9, 2024
Peripheral nerve injury is a major challenge in clinical treatment due to the limited intrinsic capacity for regeneration. Tissue engineering approaches offer promising solutions by providing biomimetic scaffolds and cell sources promote In present work, we investigated potential role of skin-derived progenitors (SKPs), which are induced into neurons Schwann cells (SCs), their extracellular matrix tissue-engineered grafts (TENGs) enhance peripheral neuroregeneration. SKPs were differentiate SCs
Language: Английский
Citations
3
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 51 - 65
Published: Aug. 17, 2024
Language: Английский
Citations
3
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 431 - 442
Published: Feb. 26, 2025
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114064 - 114064
Published: June 26, 2024
Language: Английский
Citations
2
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 31, 2024
Treatment of peripheral nerve defects is a major concern in regenerative medicine. This study therefore aimed to explore the efficacy neural graft constructed using adipose mesenchymal stem cells (ADSC), acellular microtissues (MTs), and chitosan treatment defects.
Language: Английский
Citations
0