Journal of Physics Conference Series,
Journal Year:
2024,
Volume and Issue:
2808(1), P. 012041 - 012041
Published: July 1, 2024
Abstract
Hydrogel
microneedles
(MNs)
are
emerging
as
versatile
transdermal
drug
delivery
platforms
for
the
treatment
of
various
diseases.
However,
their
conventional
preparation
method
is
plagued
by
a
complex
process,
time-consuming
nature,
and
low
resolution.
To
address
these
challenges,
we
present
novel
preparing
temperature-responsive
hydrogel
MNs
using
Digital
Light
Processing
(DLP)
strategy.
The
printed
NIPAM-AA-AM
can
be
rapidly
customized
(within
1
hour)
into
shapes
heights
with
high
mechanical
tests
H&E
staining
validate
ability
to
penetrate
skin.
In
addition,
was
demonstrated
through
experiments
COSMOL
simulations.
Notably,
biocompatible
showed
non-toxicity
in
NIH-3T3
cells
hemolysis
rates,
thereby
indicating
promising
prospects
safe
vivo
utilization.
This
study
offers
simple
rapid
alternative
fabrication
smart
responsive
microneedles,
opening
up
new
avenues
personalized
efficient
strategies.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Recent
investigations
have
underscored
the
significant
role
of
manganese
ions
(Mn2+)
in
immunization,
particularly
through
activation
cGAS-STING
pathway,
which
enhances
antitumor
immune
responses.
However,
rapid
metabolism
free
Mn2+
following
administration
limits
its
effectiveness
as
an
adjuvant.
To
address
these
challenges,
microneedles
(MNs)
hyaluronic
acid
containing
Sparfloxacin
(SP)
and
zinc-manganese
sulfide
(ZMS)
are
prepared
for
postoperative
situ
treatment
triple-negative
breast
cancer
(TNBC)
to
prevent
recurrence
combat
wound
infection.
ZMS/SP
(ZS)-loaded
MNs
exhibit
strong
antimicrobial
antibiofilm
properties
that
crucial
preventing
infections.
Moreover,
generation
reactive
oxygen
species
by
disrupts
oxidative
balance,
effectively
activating
immunogenic
cell
death
facilitating
release
cytokines.
ZS
significantly
suppressed
tumor
growth,
reduced
lung
metastasis,
promoted
healing.
These
effects
accompanied
notable
increases
infiltration
activation,
is
consistent
with
gene
sequencing
results.
Activation
pathway
further
improved
immunity.
findings
highlight
potential
effective
safe
utilizes
immunostimulatory
enhance
local
systemic
responses
prevention
TNBC
metastasis.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(21)
Published: July 15, 2024
Abstract
Over
the
past
two
decades,
deep
eutectic
solvents
(DESs)
have
captured
significant
attention
as
an
emergent
class
of
that
unique
properties
and
applications
in
differing
fields
chemistry.
One
area
where
DES
systems
find
utility
is
design
polymeric
gels,
often
referred
to
“eutectogels,”
which
can
be
prepared
either
using
a
replace
traditional
solvent,
or
monomers
form
part
themselves.
Due
extensive
network
intramolecular
interactions
(e.g.,
hydrogen
bonding)
ionic
species
exist
systems,
eutectogels
possess
appealing
material
properties—high
adhesive
strength,
tuneable
viscosity,
rapid
polymerization
kinetics,
good
conductivity,
well
high
strength
flexibility.
In
addition,
non‐covalent
crosslinking
approaches
are
possible
due
inherent
these
materials.
This
review
considers
several
key
eutectogels,
including
organic
electronics,
wearable
sensor
technologies,
3D
printing
resins,
adhesives,
range
various
biomedical
applications.
The
design,
synthesis,
discussed,
addition
advantages
this
synthetic
approach
comparison
gel
design.
Perspectives
on
future
directions
field
also
highlighted.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(7), P. 1053 - 1068
Published: July 2, 2024
Introduction
Microneedles
(MNs)
are
miniaturized,
painless,
and
minimally
invasive
platforms
that
have
attracted
significant
attention
over
recent
decades
across
multiple
fields,
such
as
drug
delivery,
disease
monitoring,
diagnosis,
cosmetics.
Several
manufacturing
methods
been
employed
to
create
MNs;
however,
these
approaches
come
with
drawbacks
related
complicated,
costly,
time-consuming
fabrication
processes.
In
this
context,
employing
additive
(AM)
technology
for
MN
allows
the
quick
production
of
intricate
prototypes
exceptional
precision,
providing
flexibility
customize
MNs
according
desired
shape
dimensions.
Furthermore,
AM
demonstrates
promise
in
sophisticated
transdermal
delivery
systems
medical
devices
through
integration
various
technologies.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
