Published: Jan. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140082 - 140082
Published: Jan. 18, 2025
Language: Английский
Citations
3
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)
Published: May 27, 2024
Abstract Biofilm‐associated infections pose complex challenges that require addressing the multifaceted requirements of biofilm disruption, bacterial killing, and immunomodulation. In this study, microenvironment‐adaptive metallo‐polymeric nanodecoys (MPNs) are synthesized through one‐pot subcomponent coordination in aqueous solution, effectively eradicating biofilms modulating immune response. Within acidic microenvironment biofilms, positively charged MPNs demonstrated ability to interact with eliminate bacteria while facilitating a Fenton‐like reaction for efficient eradication biofilms. As local shifted from neutral basic state during subsequent tissue healing processes, adaptively harness multiple properties bind pathogen‐associated molecular patterns, scavenge reactive oxygen species, thereby response, alleviating inflammation, promoting healing. This study presents an strategy preparing enzyme‐mimicking materials closely resemble natural metalloenzymes, offer alternative current antibiotic treatments biofilm‐associated infections.
Language: Английский
Citations
12
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Abstract Multifunctional responsive hydrogels hold significant promise for diabetic foot ulcer (DFU) treatment, though their complex design and manufacturing present challenges. This study introduces a novel supramolecular guanosine‐phenylboronic‐chlorogenic acid (GBC) hydrogel developed using dynamic covalent strategy. The forms through guanosine quadruplex assembly in the presence of potassium ions chlorogenic (CA) linkage via borate bonds. GBC exhibit pH glucose responsiveness, releasing more under acidic high conditions due to bond dissociation G‐quadruplex (G4) disintegration. Experimental results indicate that good self‐healing, shear‐thinning, injectability, swelling properties. Both vitro vivo studies demonstrate hydrogel's biocompatibility, ability eliminate bacteria reactive oxygen species (ROS), facilitate macrophage polarization from M1 phenotype M2 (decreasing CD86 expression increasing CD206 expression), anti‐inflammatory effects (reducing TNF‐α IL‐10 promote angiogenesis (increasing VEGF, CD31, α‐SMA expression). Thus, accelerate DFU healing enhance tissue remodeling collagen deposition. work provides new approach developing expedite healing.
Language: Английский
Citations
5
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 10, 2024
The World Health Organization has warned that without effective action, deaths from drug-resistant bacteria can exceed 10 million annually, making it the leading cause of death. Conventional antibiotics are becoming less due to rapid bacterial drug resistance and slowed new antibiotic development, necessitating strategies. Recently, materials with catalytic/enzymatic properties, known as nanozymes, have been developed, inspired by natural enzymes essential for eradication. Unlike recent literature reviews broadly cover nanozyme design biomedical applications, this review focuses on latest advancements in nanozymes combating resistance, emphasizing their design, structural characteristics, applications combination therapy, future prospects. This approach aims promote development especially towards clinical translation.
Language: Английский
Citations
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 15, 2025
Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive environments, such as hyperglycemia, bacterial infection, impaired angiogenesis. However, current are complicated need on-demand sequential release synergy of multicomponents. Herein, H2S-releasing cascade nanozyme (FeS@Au), which is composed ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), developed single component regulate glucose level, eliminate promote angiogenesis, achieving for diabetic treatment. The oxidase-like activity AuNC catalyzes into gluconic acid H2O2, not only lowers the local level but also decreases pH increases H2O2 boost peroxidase-like FeSNP generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, H2S acidified environment upregulate hypoxia-inducible factor-1 enhance vascularization through upregulating expression vascular endothelial growth factor (VEGF) other angiogenesis-related genes, reducing damage cells caused by excessive ROS produced nanozyme. In full-thickness MRSA-infected rat model, FeS@Au significantly eliminates bacteria, enhances promotes collagen deposition, accelerates healing. This work with H2S-release interventions, providing versatile strategy extensive tissue diabetes.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113666 - 113666
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113772 - 113772
Published: April 1, 2025
Language: Английский
Citations
0