Extracellular Vesicles in the HCC Microenvironment: Implications for Therapy and Biomarkers DOI Creative Commons

Le Cheng,

Limin Zhang,

Xiaoxiao Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107419 - 107419

Published: Sept. 1, 2024

Language: Английский

Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems DOI
Waleed Y. Rizg, Majed Alghamdi, Sherif El Saadany

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106696 - 106696

Published: Feb. 6, 2025

Language: Английский

Citations

1
Unlocking the Potential of RGD-Conjugated Gold Nanoparticles: A New Frontier in Targeted Cancer Therapy, Imaging, and Metastasis Inhibition DOI
Hossein Javid, Mahsa Akbari Oryani,

Nastaran Rezagholinejad

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10786 - 10817

Published: Jan. 1, 2024

The review highlights the potential of RGD-conjugated AuNPs in cancer diagnosis and treatment, including breast cancer. It emphasizes need for further research to fully realize this technology’s inspire future investigations.

Language: Английский

Citations

5
Extracellular Vesicle‐Based Antitumor Nanomedicines DOI Open Access
Mingfeng Li, Yanfei Liu, Fei Liu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Extracellular vesicles (EVs) have emerged as promising bioactive carriers for delivering therapeutic agents, including nucleic acids, proteins, and small‐molecule drugs, owing to their excellent physicochemical stability biocompatibility. However, comprehensive reviews on the various types of EV‐based nanomedicines cancer therapy remain scarce. This review explores potential EVs antitumor nanomedicines. Methods EV extraction, drug loading, engineering modifications are systematically examined, strengths limitations these technical approaches critically assessed. Additionally, key strategies developing therapies highlighted. Finally, opportunities challenges associated with advancing toward clinical translation discussed. With integration multiple disciplines, robust platforms expected be manufactured provide more personalized effective solutions oncology patients.

Language: Английский

Citations

0
Exosomes: A Promising Drug Delivery Tool in Hepatic Drug Delivery DOI
Neha Kanojia,

Komal Thapa,

Thakur Gurjeet Singh

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761

Published: March 1, 2025

Language: Английский

Citations

0
Crosstalk between exosomes and tumor-associated macrophages in hepatocellular carcinoma: implication for cancer progression and therapy DOI Creative Commons
Ying Xu, Lin Xu, Qiuyan Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Hepatocellular carcinoma (HCC), the most prevalent type of primary liver cancer, represents a significant cause cancer-related mortality. While our understanding its pathogenesis is comparatively comprehensive, influence tumor microenvironment (TME) on progression warrants additional investigation. Tumor-associated macrophages (TAMs) have impacts cancer cell proliferation, migration, invasion, and immune response, facilitating complex interaction within TME. Exosomes, which measure between 30 150 nanometers in size, are categorized into small extracellular vesicles, secreted by wide range eukaryotic cells. They can transfer biological molecules including proteins, non-coding RNAs, lipids, mediates intercellular communication Emerging evidence has revealed that exosomes regulate macrophage polarization, thus impacting responses TME HCC. Moreover, TAM-derived also play crucial roles malignant transformation, hold immense potential for therapy. In this review, we elaborate crosstalk TAMs during HCC development. delve feasible treatment approaches therapy emphasize limitations challenges translation derived from clinical courses therapy, may provide new perspectives further ameliorations therapeutic regimes based to advance their applications.

Language: Английский

Citations

0
Targeting lipid metabolism via nanomedicine: a prospective strategy for cancer therapy DOI

Xing Huang,

Shengzhong Hou,

Yinggang Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123022 - 123022

Published: Dec. 15, 2024

Language: Английский

Citations

2
Extracellular Vesicles in the HCC Microenvironment: Implications for Therapy and Biomarkers DOI Creative Commons

Le Cheng,

Limin Zhang,

Xiaoxiao Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107419 - 107419

Published: Sept. 1, 2024

Language: Английский

Citations

0