Physica Scripta,
Journal Year:
2024,
Volume and Issue:
99(7), P. 075026 - 075026
Published: June 5, 2024
Abstract
Hydrogels
are
ideal
for
creating
wound
dressings
but
fabricating
such
hydrogels
with
strong
antibacterial
properties
and
high
biosafety
is
complex
due
to
their
unique
properties.
Therefore,
the
present
work
proposes
preparation
of
chitosan-silver-moringa
gum
composite
hydrogel
(CAM)
excellent
bactericidal
action.
The
solvent-free,
ecologically
friendly,
cost-effective
sets
a
new
standard
sustainable
production.
CAM
showed
maximum
swelling
in
distilled
water
after
24
h.
produced
has
characteristic
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
x-ray
diffraction
(XRD)
pattern.
inhibited
Hela
cell
lines
by
100
±
0.56%
at
30
μ
g
ml
−1
an
IC50
13.89
0.8
via
MTT
assay.
Scanning
Electron
Microscope
(SEM)
hydrogel’s
porous
structure
whereas
(EDX)
analysis
revealed
presence
silver
matrix.
Additionally,
DPPH
assay
82.06
1.39%
antioxidant
activity
0.9
mg
hydrogel.
in-vitro
protein
denaturation
assay,
hydrogel,
59.7
2.52%
inhibition
compared
diclofenac
87.89
0.47%
1
,
indicating
anti-inflammatory
efficacy.
steady
behaviour
from
105
170
°C
weight
loss
2.77%,
making
it
suitable
steam
sterilisation
as
dressing
material.
different
glass
transition
temperature
(Tg)
curve
chitosan
moringa
gum,
its
successful
demonstrated
promising
against
all
tested
strains,
biobased
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 29, 2025
The
challenges
associated
with
prolonged
healing
or
non-healing
of
chronic
diabetic
wounds
contribute
significantly
to
the
increased
incidence
lower
limb
amputation.
A
pivotal
factor
in
impediment
is
reduced
production
endogenous
nitric
oxide
(NO)
due
hyperglycemic
microenvironment
typical
diabetes.
While
both
and
exogenous
NO
have
been
shown
promote
process
wounds,
direct
application
wound
management
limited
its
gaseous
nature
risk
explosive
release.
This
review
summarizes
recent
advances
nanodressings
incorporating
donors
treatment
detailing
specific
conditions
under
which
these
facilitate
release,
a
focus
on
beneficial
effects
NO,
strategies
for
supplementation,
encountered
clinical
translation
as
clinically
viable
nanomedicine
context
improving
healing.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
26(1), P. 689 - 704
Published: Jan. 1, 2025
Chitosan-based
materials
are
known
for
their
excellent
biocompatibility
and
inherent
hemostatic
properties.
However,
efficiency
is
significantly
affected
by
poor
wettability
mechanical
strength.
Herein,
we
developed
a
novel
super
elastic
sponge
from
mussel-inspired
chitosan
modified
with
long
alkyl
catechol
functional
groups
(HMCC)
via
simple
freezing-drying
procedure.
The
incorporation
of
decanal
in
the
HMCC
enhances
its
antimicrobial
antioxidant
properties
facilitates
multiple
interactions
blood
cells,
thus
promoting
enrichment
rapid
hemostasis.
Moreover,
sponges
exhibit
high
compressibility
fluid-induced
size
recovery
capacity,
enabling
wound
shape
adaptation
to
ensure
minimizing
irritation.
In
vivo
experiments
revealed
that
possessed
enhanced
procoagulant,
hemostasis
abilities,
favorable
degradability
could
promote
healing
rat
skin
model.
These
results
highlight
potential
as
promising
solution
clinical
management
major
bleeding.
Advances in Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
338, P. 103398 - 103398
Published: Jan. 9, 2025
Biopolymers
derived
from
natural
resources
are
highly
abundant,
biodegradable,
and
biocompatible,
making
them
promising
candidates
to
replace
non-renewable
fossil
fuels
mitigate
environmental
health
impacts.
Nano-fibrous
biopolymers
possessing
advantages
of
entangle
with
each
other
through
inter-/intra-molecular
interactions,
serving
as
ideal
building
blocks
for
gel
construction.
These
biopolymer
nanofibers
often
synergize
nano-building
enhance
gels
desirable
functions
eco-friendliness
across
various
applications
in
biomedical,
environmental,
energy
sectors.
The
interactions
directly
affect
the
assembly
blocks,
which
determines
structure
gels,
integrity
connected
influencing
mechanical
properties
performance
specific
applications.
This
review
focuses
on
four
(cellulose,
chitin,
silk,
collagen),
commonly
used
preparations,
representatives
polysaccharides
polypeptides.
covalent
non-covalent
between
materials
have
been
categorized
discussed
relation
resulting
network
structures
properties.
Nanomechanical
characterization
techniques,
such
surface
forces
apparatus
(SFA)
atomic
force
microscopy
(AFM),
employed
precisely
quantify
intermolecular
blocks.
these
classified
correlated
their
act
"sewing
threads",
connecting
all
establish
suitable
functions.
aims
provide
a
comprehensive
understanding
involved
preparation
design
principles
needed
achieve
targeted
functional
gels.
