Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair DOI Creative Commons
Pingming Qiu, Lei Wang, Jing Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 14, 2024

With the rapid progress of industrialization, incidence peripheral nerve injuries caused by trauma has been continuously increasing. These result in a significant number disabilities and irreversible functional impairments, not only severely impacting health quality life patients but also placing heavy economic burden on families society. Effectively promoting regeneration thus become key focus challenge current research. In recent years, hybrid biohydrogels with adhesive properties have gained widespread attention due to their excellent biocompatibility, mechanical stability, conductivity, biodegradability. materials can provide an optimal microenvironment promote neuron adhesion axonal extension while offering outstanding strength meet fixation requirements clinical surgeries. This paper systematically reviews application injury repair, highlighting latest research improving recovery, discusses challenges future prospects for application.

Language: Английский

3D Bioprinting of Double‐Layer Conductive Skin for Wound Healing DOI
Yuhan Wang, Chen Gao,

Shengnan Cheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Conductive hydrogels are highly attractive in 3D bioprinting of tissue engineered scaffolds for skin injury repair. However, their application is limited by mismatched electrical signal conduction mode and poor printability. Herein, the bioprinting‐assisted fabrication a double‐layer ionic conductive scaffold using newly designed biomimetic bioink (GHCM) reported, which composed gelatin methacrylate (GelMA), oxidized hyaluronic acid (OHA), carboxymethyl chitosan (CMCS), 2‐methacryloyloxyethyl phosphorylcholine (MPC) treatment full‐thickness defects. The combination rigid (GelMA) dynamic (OHA‐CMCS) polymer networks imparts GHCM excellent reversible thixotropy, enabling good printability, allowing creation skin‐like constructs with high shape fidelity cell activity convenient one‐step bioprinting. Moreover, incorporation zwitterionic MPC endows signaling pattern similar to that natural tissue. By integrating human foreskin fibroblasts (HFF‐1), umbilical vein endothelial cells (HUVECs), immortalized keratinocytes (HaCaTs), comprising an epidermal layer vascularized dermal created. In vivo experiments have demonstrated provide appropriate microenvironment cellular signaling, growth, migration, differentiation, ultimately accelerating re‐epithelialization, collagen deposition, vascularization wounds, may represent general versatile strategy precise engineering electroactive tissues regenerative medicine applications.

Language: Английский

Citations

1
Near-infrared light-responsive nanocomposite hydrogels loaded with epidermal growth factor for diabetic wound healing DOI Creative Commons
Miao Li,

Xue Feng Lu,

Yaoyao Wei

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101578 - 101578

Published: Feb. 14, 2025

In diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around wound, resulting in proliferation dermal epidermal cells skin regeneration wounds. To solve above problems, this study designed near-infrared (NIR) light-responsive multifunctional poloxamer hydrogel (EGF/PDA-MXene Gel). The Gel composed two-dimensional nanomaterials (2D NMs) MXene as core, modified polymer, further loaded with growth factor (EGF), has antibacterial, antioxidant, photothermal properties. Meanwhile, EGF/PDA-MXene can be used drug repository, alleviating problem short half-life, realizing sustained release EGF. NIR property induces protein denaturation leading to death pathogenic bacteria, avoiding common clinical antibiotic resistance. addition, promotes chronic wound healing promoting regeneration, collagen deposition, angiogenesis, several other mechanisms. Therefore, preparation strategies that combine bioactive molecules 2D NMs, which maintains activity EGF while exploiting antimicrobial advantages NMs photothermally, provide new promising therapeutic approach for accelerating repair infected

Language: Английский

Citations

0
Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring DOI
Xiao Wang,

Haoling Huo,

Lin Cao

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 153 - 169

Published: Dec. 12, 2024

Language: Английский

Citations

4
Visible light-activated Ti-MOF loaded metformin-hydrogel composite dressing for accelerated chronic diabetic wound healing DOI
Meng Tian,

Chuan Fan,

Rujiao Ge

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160179 - 160179

Published: Jan. 1, 2025

Language: Английский

Citations

0
Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing DOI Creative Commons

Haozeng,

Qinghong Lai,

Wanyou Liao

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113714 - 113714

Published: Feb. 1, 2025

Language: Английский

Citations

0
Low-frequency ultrasound-driven piezoelectric films repair neuro-immune circuits in diabetic wound healing DOI Creative Commons

Chenyan Yu,

Ying Hu, Xin Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162045 - 162045

Published: April 1, 2025

Language: Английский

Citations

0
Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds DOI
Wei‐Chien Huang,

Qianru Guo,

Hongrong Wu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

Inducing rapid angiogenesis by delivering specific biological cues is critical for diabetic wound healing. Nevertheless, the hindered inflammatory microenvironment, and immune cells fail to orchestrate responses Herein, vascular endothelial growth factor (VEGF) plasmids-loaded macrophage exosomes (Exos) were fabricated enfolded in injectable self-healing hydrogels programmed therapy of wounds through sequentially intrinsically modulating microenvironment promoting angiogenesis. The hydrogels, formed via dynamical Schiff base reactions using modified polysaccharides, regulate broad-spectrum antioxidant activity phenotype regulation, restoring tissue redox homeostasis. Furthermore, can stabilize release engineered exosomes. By integration generation VEGF Exos, secretion M2 macrophages, enhanced binding receptor 2 high affinity sulfated chitosan, intrinsic immunomodulatory effectively promote accelerate healing process.

Language: Английский

Citations

0
Living photosynthetic microneedle patches for in situ oxygenation and postsurgical melanoma therapy DOI Creative Commons
Jinxuan Jia, Xuhong Guo, Y. Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 11, 2024

Surgical excision remains the principal treatment for melanoma, while tumor recurrence and delayed wound healing often occur due to residual cells hypoxic microenvironment in postoperative skin wounds. Herein, we present a living photosynthetic microneedle (MN) patch (namely MA/CM@MN) loaded with microalgae (MA) cuttlefish melanin (CM) postsurgical melanoma therapy healing. Benefiting from oxygenic photosynthesis of alive MA MN base, MA/CM@MN can generate oxygen under light exposure, thus facilitating cell proliferation protecting against hypoxia-induced death. In addition, CM nanoparticles embedded tips, be effectively heated up near-infrared (NIR) irradiation, contributing strong killing efficacy on vitro. Further experiments demonstrate that NIR-irradiated prevents local simultaneously promotes tumor-induced wounds after incomplete resection melanoma-bearing mice, probably because inhibit proliferation, stimulate apoptosis, mitigate tissue hypoxia light. These results indicate offers an effective therapeutic strategy cancer applications.

Language: Английский

Citations

1
Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair DOI Creative Commons
Pingming Qiu, Lei Wang, Jing Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 14, 2024

With the rapid progress of industrialization, incidence peripheral nerve injuries caused by trauma has been continuously increasing. These result in a significant number disabilities and irreversible functional impairments, not only severely impacting health quality life patients but also placing heavy economic burden on families society. Effectively promoting regeneration thus become key focus challenge current research. In recent years, hybrid biohydrogels with adhesive properties have gained widespread attention due to their excellent biocompatibility, mechanical stability, conductivity, biodegradability. materials can provide an optimal microenvironment promote neuron adhesion axonal extension while offering outstanding strength meet fixation requirements clinical surgeries. This paper systematically reviews application injury repair, highlighting latest research improving recovery, discusses challenges future prospects for application.

Language: Английский

Citations

1