Physica Scripta,
Journal Year:
2024,
Volume and Issue:
99(7), P. 075026 - 075026
Published: June 5, 2024
Abstract
Hydrogels
are
ideal
for
creating
wound
dressings
but
fabricating
such
hydrogels
with
strong
antibacterial
properties
and
high
biosafety
is
complex
due
to
their
unique
properties.
Therefore,
the
present
work
proposes
preparation
of
chitosan-silver-moringa
gum
composite
hydrogel
(CAM)
excellent
bactericidal
action.
The
solvent-free,
ecologically
friendly,
cost-effective
sets
a
new
standard
sustainable
production.
CAM
showed
maximum
swelling
in
distilled
water
after
24
h.
produced
has
characteristic
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
x-ray
diffraction
(XRD)
pattern.
inhibited
Hela
cell
lines
by
100
±
0.56%
at
30
μ
g
ml
−1
an
IC50
13.89
0.8
via
MTT
assay.
Scanning
Electron
Microscope
(SEM)
hydrogel’s
porous
structure
whereas
(EDX)
analysis
revealed
presence
silver
matrix.
Additionally,
DPPH
assay
82.06
1.39%
antioxidant
activity
0.9
mg
hydrogel.
in-vitro
protein
denaturation
assay,
hydrogel,
59.7
2.52%
inhibition
compared
diclofenac
87.89
0.47%
1
,
indicating
anti-inflammatory
efficacy.
steady
behaviour
from
105
170
°C
weight
loss
2.77%,
making
it
suitable
steam
sterilisation
as
dressing
material.
different
glass
transition
temperature
(Tg)
curve
chitosan
moringa
gum,
its
successful
demonstrated
promising
against
all
tested
strains,
biobased
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Abstract
Chronic
wounds
impose
significant
physical
and
mental
burdens
on
patients.
Nano‐based
formulations
offer
a
promising
strategy
for
chronic
wound
healing
due
to
their
non‐invasive
nature
enhanced
biofilms
penetration,
but
they
often
lack
targeting
capability
or
fail
achieve
long‐term
synergistic
effects.
In
this
work,
multifunctional
microneedle
(MN)
patch
loaded
with
engineered
nitric
oxide
(NO)‐releasing
nanocarriers
are
presented
that
encapsulate
an
antibacterial
agent
immobilized
Concanavalin
A
(Con
A)
NO
molecules
targeted
treatment
of
wounds.
With
the
assistance
MNs,
nanoparticles
(NPs)
can
directly
cross
bacterial
be
efficiently
delivered
tissues,
where
target
harmful
bacteria
through
specific
recognition
between
Con
polysaccharides
surfaces,
followed
by
release
encapsulated
antimicrobial
agent,
thereby
achieving
effective
effect.
Moreover,
NPs
generate
in
sustained
manner
as
dissociate
tissue,
which
exerts
potent
anti‐inflammatory
action
benefits
tissue
regeneration,
further
promoting
closure.
Consequently,
work
provides
novel
MN
designed
accelerating
therapy.
Medical Gas Research,
Journal Year:
2024,
Volume and Issue:
15(1), P. 23 - 35
Published: July 25, 2024
Non-healing
wounds
are
long-term
complications
of
diabetes
mellitus
(DM)
that
increase
mortality
risk
and
amputation-related
disability
decrease
the
quality
life.
Nitric
oxide
(NO·)-based
treatments
(i.e.,
use
both
systemic
topical
NO·
donors,
precursors,
inducers)
have
received
more
attention
as
complementary
approaches
in
DM
wounds.
Here,
we
aimed
to
highlight
potential
benefits
NO·-based
on
through
a
literature
review
experimental
clinical
evidence.
Various
been
used.
In
rodents,
therapy
facilitates
wound
healing,
manifested
an
increased
healing
rate
decreased
half-closure
time.
The
effect
is
attributed
increasing
local
blood
flow,
angiogenesis
induction,
collagen
synthesis
deposition,
re-epithelization,
anti-inflammatory
anti-oxidative
properties,
potent
broad-spectrum
antibacterial
effects.
existing
lacks
human
evidence
safety
efficacy
for
Translating
favors
into
practice
needs
conducting
trials
with
well-predefined
sizes,
i.e.,
reduction
area,
hospital
length
stay.
Physica Scripta,
Journal Year:
2024,
Volume and Issue:
99(7), P. 075026 - 075026
Published: June 5, 2024
Abstract
Hydrogels
are
ideal
for
creating
wound
dressings
but
fabricating
such
hydrogels
with
strong
antibacterial
properties
and
high
biosafety
is
complex
due
to
their
unique
properties.
Therefore,
the
present
work
proposes
preparation
of
chitosan-silver-moringa
gum
composite
hydrogel
(CAM)
excellent
bactericidal
action.
The
solvent-free,
ecologically
friendly,
cost-effective
sets
a
new
standard
sustainable
production.
CAM
showed
maximum
swelling
in
distilled
water
after
24
h.
produced
has
characteristic
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
x-ray
diffraction
(XRD)
pattern.
inhibited
Hela
cell
lines
by
100
±
0.56%
at
30
μ
g
ml
−1
an
IC50
13.89
0.8
via
MTT
assay.
Scanning
Electron
Microscope
(SEM)
hydrogel’s
porous
structure
whereas
(EDX)
analysis
revealed
presence
silver
matrix.
Additionally,
DPPH
assay
82.06
1.39%
antioxidant
activity
0.9
mg
hydrogel.
in-vitro
protein
denaturation
assay,
hydrogel,
59.7
2.52%
inhibition
compared
diclofenac
87.89
0.47%
1
,
indicating
anti-inflammatory
efficacy.
steady
behaviour
from
105
170
°C
weight
loss
2.77%,
making
it
suitable
steam
sterilisation
as
dressing
material.
different
glass
transition
temperature
(Tg)
curve
chitosan
moringa
gum,
its
successful
demonstrated
promising
against
all
tested
strains,
biobased
