
Food Chemistry X, Journal Year: 2024, Volume and Issue: 25, P. 102086 - 102086
Published: Dec. 10, 2024
Language: Английский
Food Chemistry X, Journal Year: 2024, Volume and Issue: 25, P. 102086 - 102086
Published: Dec. 10, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 3, 2025
Language: Английский
Citations
0Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107516 - 107516
Published: March 1, 2025
Language: Английский
Citations
0Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0Published: Jan. 1, 2025
Language: Английский
Citations
0Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Language: Английский
Citations
0Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 14(1)
Published: Nov. 25, 2024
Therapeutic option for treating methicillin-resistant
Language: Английский
Citations
2European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117012 - 117012
Published: Oct. 30, 2024
Language: Английский
Citations
1Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 30, 2024
Methicillin-resistant Staphylococcus aureus (MRSA), one of the most important zoonotic bacterial pathogens, necessitates innovative antibacterial strategies. Rosmarinic acid (RA) possesses various biological functions, including and anti-inflammatory effects. This study aimed to explore synergistic effects mechanism RA in conjunction with ceftiofur (CF) against MRSA. Results showed that combination CF demonstrated anti-MRSA activity, conferring protective an MRSA bacteremia mouse model. Mechanistic investigations further established interacts sortase A (SrtA) through hydrogen bonds, electrostatic, van der Waals forces at critical sites, leading reversible inhibition SrtA activity. Consequently, this impeded ability invade cells form biofilms. Conclusively, directly inhibits thus enhancing effect CF. These findings provide a theoretical foundation for use as therapeutic strategy infections.
Language: Английский
Citations
1Food Chemistry X, Journal Year: 2024, Volume and Issue: 25, P. 102086 - 102086
Published: Dec. 10, 2024
Language: Английский
Citations
0