PEGylated PAMAM Dendrimer Nanoplatform for Co-delivery of Chemotherapeutic Agents and Inorganic Nanoparticles Enhancing Chemo-Photothermal Combination Therapy DOI

Binzhong Lu,

Yingying Yang, Xiang Li

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114688 - 114688

Published: April 1, 2025

Language: Английский

Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma DOI Creative Commons
Jie Chen,

C. Q. Feng,

Yufei Lan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 8, 2025

Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy NPC. Specifically, have encapsulated metformin (Met) and copper sulfide nanoparticles (CuS NPs) within injectable DNA supramolecular hydrogels (DSH) to create a novel radiosensitizer, Met-CuS@DSH. This radiosensitizer not only effectively reverses hypoxia promote reactive oxygen species (ROS) generation but also significantly inhibits glutathione (GSH)-mediated ROS scavenging, thereby achieving by enhancing production suppressing scavenging. improves effect of NPC while reducing RT dose (3 Gy in total), which provides promising approach overcoming caused TME.

Language: Английский

Citations

0
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis DOI

Wenqian Zheng,

Yang Liu, Jinru Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137337 - 137337

Published: March 1, 2025

Language: Английский

Citations

0
Defect-Engineered Magnetic Bismuth Nanomedicine for Dual-Modal Imaging and Synergistic Lung Tumor Therapy DOI Creative Commons

Pengpeng Jia,

Jie Tu, Hongyu Shen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101680 - 101680

Published: March 1, 2025

Language: Английский

Citations

0
pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment DOI Creative Commons
Le He,

Zahra Javid Anbardan,

Pamela Habibović

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113883 - 113883

Published: March 1, 2025

Language: Английский

Citations

0
PEGylated PAMAM Dendrimer Nanoplatform for Co-delivery of Chemotherapeutic Agents and Inorganic Nanoparticles Enhancing Chemo-Photothermal Combination Therapy DOI

Binzhong Lu,

Yingying Yang, Xiang Li

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114688 - 114688

Published: April 1, 2025

Language: Английский

Citations

0