Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.

Language: Английский

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ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.

Language: Английский

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Recent Advances in Biomimetic Nanodelivery Systems for the Treatment of Depression

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101781 - 101781

Published: April 17, 2025

Depression and cognitive disorders remain major challenges in healthcare, with conventional treatments often facing limitations such as slow onset, side effects, poor drug delivery to the brain. Biomimetic nanodelivery systems, including nanozymes, cell membrane-based exosomes, have emerged promising solutions these issues. These systems leverage natural biological processes enhance targeting, improve bioavailability, regulate complex pathways. Nanoenzymes, their catalytic properties, offer antioxidant anti-inflammatory benefits, while membranes exosomes provide efficient targeting immune evasion. However, remain, immaturity of large-scale production techniques, stability concerns, incomplete understanding mechanisms action. Moreover, long-term safety, pharmacokinetics, toxicity require further investigation. Despite obstacles, potential biomimetic revolutionize depression treatment is significant. Future research should focus on optimizing preparation, improving release, ensuring clinical safety. Multidisciplinary collaboration will be essential for advancing from laboratory practice, offering new therapeutic avenues other neurological disorders.

Language: Английский

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Transmembrane protein 16A in the digestive diseases: A review of its physiology, pharmacology, and therapeutic opportunities

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143598 - 143598

Published: April 27, 2025

Language: Английский

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