Case Studies in Thermal Engineering,
Journal Year:
2024,
Volume and Issue:
61, P. 105074 - 105074
Published: Sept. 1, 2024
The
complete
investigation
of
the
solubility
Ceftriaxone
sodium
drug
has
not
yet
been
conducted.
This
communication
investigates
in
supercritical
CO2
(SC-CO2)
for
first
time.
measurements
were
performed
using
utilizing
UV-vis
analysis
under
different
operation
conditions
(at
P
(bar)
=
120-270
and
T
(K)
308-338).
results
demonstrated
that
ranged
from
0.90
×
10-6
to
8.01
10-6.
mole
fraction
increases
proportionally
with
an
increase
pressure,
while
maintaining
a
constant
temperature.
However,
crossover
was
noted.
behavior
SC-CO2
modeled
by
Peng-Robinson
equation
state
(PR
EoS)
Kwak-Mansoori
van
der
Waals
mixing
rules
seven
semi-empirical
correlations
(Bian
et
al.,
Kumar-Johnston,
Chrastil,
Garlapati-Madras,
Bartle
Sung-Shim
Sodeifian
al.,).
vaporization,
total
solvation
enthalpies
sodium/SC-carbon
dioxide
system
obtained
KJ,
al.
correlations.
evaluation
two
methods
absolute
average
relative
deviation
(AARD%).
Both
models
exhibited
satisfactory
level
agreement
experimental
data.
Finally,
PR/KM
EoS
Chrastil
models,
AARD%
values
8.70%
8.10%
respectively,
showed
superior
precision
accurately
fitting
Journal of Chemical & Engineering Data,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
This
study
investigates
the
solubility
of
Baclofen
in
supercritical
CO2,
which
is
essential
for
developing
an
efficient
drug
delivery
system
using
processes.
Solubility
measurements
were
carried
out
both
with
and
without
presence
various
cosolvents
(ethanol
dimethyl
sulfoxide
(DMSO)),
across
a
temperature
range
308–338
K
pressure
12–30
MPa.
exhibited
ranging
from
1.62
×
10–5
to
2.30
mole
fractions
pure
CO2.
In
cosolvents,
increased
5.76
12.79
ethanol
3.50
7.02
DMSO.
Indeed,
addition
DMSO
by
approximately
3.55–5.56
times
2.15–3.05
times,
respectively.
Several
density-based
empirical
models
thermodynamic
(Soave–Redlich–Kwong
(SRK)
Peng–Robinson
(PR)
equations
state)
used
correlate
data.
Jafari
Nejad's
model
CO2–Baclofen
Jouyban's
CO2–ethanol/DMSO–Baclofen
systems
displayed
higher
consistency.
Also,
PR
showed
better
accuracy
correlating
while
SRK
outperformed
CO2–ethanol/DMSO
cosolvents.
Moreover,
machine
learning
exceptional
accuracy,
over
99%
predictions
closely
matching
experimental
data,
emphasizing
its
outstanding
performance.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 26, 2025
The
supercritical
antisolvent
(SAS)
method
can
effectively
improve
the
bioavailability
of
poorly
water-soluble
drugs.
However,
current
equipment
and
processes
were
not
fully
developed,
making
industrialization
difficult
to
achieve.
Therefore,
an
externally
adjustable
annular
gap
nozzle
its
supporting
designed.
Curcumin
was
used
as
a
model
drug,
ethanol
solvent,
carbon
dioxide
(SC-CO2)
antisolvent.
Building
on
single-factor
experiments,
Box-Behnken
Design-Response
Surface
Methodology
(BBD-RSM)
employed
systematically
investigate
effects
four
process
parameters—crystallizer
pressure
(12–16
MPa),
crystallizer
temperature
(313–323
K),
solution
concentration
(1–2
mg/mL),
CO2/solution
flow
rate
ratio
(133–173
g/g)—on
morphology
particle
size
curcumin
particles.
Using
scanning
electron
microscopy
(SEM)
dynamic
light
scattering
(DLS)
analyses,
morphologies
mean
diameter
ranges
examined.
To
look
into
how
SAS
affects
TML's
chemical
physical
characteristics,
X-ray
diffraction
analysis
(XRD)
Fourier-transform
infrared
spectroscopy
(FT-IR)
further
performed.
Experimental
results
show
that,
had
greatest
effect
size,
followed
by
concentration,
while
least
influence.
optimum
conditions
are
operational
set
with
15
MPa,
320
K,
1.2
mg/mL,
134
g/g,
resulting
in
submicron
particles
average
808
nm
being
obtained.
This
study
demonstrated
feasibility
associated
process,
showcasing
significant
potential
for
reducing
enhancing
Journal of Toxicology,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:
The
safety
of
combining
tamsulosin
(an
allopathic
drug)
and
Croton
membranaceus
aqueous
extract,
a
medicinal
plant
for
managing
benign
prostatic
hyperplasia
(BPH),
was
investigated.
Methods:
roots
CM
were
used
processed
into
water
extract
by
maceration
decoction.
Thirty-five
Sprague
Dawley
rats
divided
seven
groups
five
each.
Groups
2-7
orchidectomy/testosterone
injections
BPH-induced.
Group
1
designated
as
the
control
group.
2
model
group
(untreated).
3
treated
with
0.03
mg/kg
b.wt.
tamsulosin.
4
received
30
(low
dose
[LD]).
5
300
(high
[HD]);
6
plus
CM.
7
Tamsulosin
administered
oral
gavage
28
days.
Prostate-specific
antigen
(PSA)
levels,
renal
liver
function
tests,
histology
assessed.
Results:
PSA
decreased
after
treatment
LD
(0.44
±
ng/mL)
(0.43
0.04
combined,
compared
(0.63
(p
<
0.006).
Prostate
gland/accessory
organ
weights
follows:
HD/T
LD/T
HD
model.
In
group,
acini
appeared
empty
fluid
contained
fatty
droplets
slender
outer
boundary
that
had
very
little
active
mucous
surface.
At
higher
dose,
caused
reduction
in
sizes
shapes
most
being
having
surfaces.
Conclusion:
results
suggest
combination
C.
does
not
provide
additional
therapeutic
benefits
treating
BPH.
Relative
better
evaluation
metric
than
total
weights.
