Results in Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: unknown, P. 100374 - 100374
Published: Dec. 1, 2024
Language: Английский
Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(2)
Published: Jan. 2, 2025
ABSTRACT Enantioseparation and enantiorecognition are crucial in the pharmaceutical analysis of chiral substances, impacting safety, efficacy, regulatory compliance. refers to process separating enantiomers from a mixture, typically achieved through chromatography techniques like HPLC SFC. In contrast, involves identification based on their interaction with selector without need for separation. Recent advancements these have significantly improved enantioseparation efficiency resolution. Chiral stationary phases (CSPs) evolved, offering better selectivity, including hybrid organic–inorganic materials miniaturization. The use green solvents has also reduced environmental impact. Non‐chromatographic methods, such as circular dichroism (CD) nuclear magnetic resonance (NMR) spectroscopy, enable interactions polarized light or solvents. However, methods face challenges, high costs, limited solvent compatibility, shorter operational lifespans compared chromatographic techniques. developments solvent‐tolerant CSPs aim address limitations. This review highlights innovations, focusing relevance industry, pollution control, quality assurance, emphasizes growing importance production regulation drugs.
Language: Английский
Citations
1
Chirality, Journal Year: 2025, Volume and Issue: 37(1)
Published: Jan. 1, 2025
ABSTRACT Efficient enantioselective separation is a critical process in pharmaceutical and chemical industries for the production of chiral compounds. Herein, we developed novel approach efficient primary amines using supercritical fluid chromatography (SFC) with commercially available SFC column, Cel1 . The key factors separation, including cosolvent ratios, total percentages, temperature, were systematically assessed this study. It revealed that utilization mixture consisting methanol isopropanol 1:3 (v/v) ratio low percentage 5% resulted superior retention selectivity. Additionally, it was observed maintaining mid‐range temperatures at 30 35°C achieved optimal balance between efficiency. Employment columns streamlined process, reducing analysis time labor. This study highlights effectiveness as powerful tool conducting high‐throughput separations fine industries.
Language: Английский
Citations
0
Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 300 - 300
Published: Jan. 22, 2025
The extraction of bioactive compounds, such as flavonoids and coumarins, from natural sources has gained significant attention due to their potential health benefits. This review aims explore the application high-pressure processes, particularly supercritical fluid (SFE) pressurized liquid (PLE), for obtaining coumarins flower seeds. These techniques offer a greener, more efficient alternative conventional methods, minimizing use harmful solvents improving yield purity target compounds. Flower seeds, rich source molecules, are an underutilized reservoir these valuable For example, seeds plants Calendula officinalis (calendula) Helianthus annuus (sunflower) in coumarins. proposed will examine influence parameters—such temperature, pressure, solvent choice, time—on quality provide comprehensive understanding methods optimize protocols efficient, sustainable
Language: Английский
Citations
0
Food Chemistry, Journal Year: 2025, Volume and Issue: 480, P. 143940 - 143940
Published: March 19, 2025
Language: Английский
Citations
0
Fluid Phase Equilibria, Journal Year: 2025, Volume and Issue: unknown, P. 114456 - 114456
Published: May 1, 2025
Language: Английский
Citations
0
Journal of CO2 Utilization, Journal Year: 2024, Volume and Issue: 88, P. 102932 - 102932
Published: Sept. 20, 2024
Language: Английский
Citations
2
Results in Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: unknown, P. 100374 - 100374
Published: Dec. 1, 2024
Language: Английский
Citations
0