In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 794 - 809

Published: Jan. 28, 2023

Language: Английский

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Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(9), P. 7017 - 7036

Published: April 17, 2024

Language: Английский

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Role of STAT3 in the initiation, progression, proliferation and metastasis of breast cancer and strategies to deliver JAK and STAT3 inhibitors

Life Sciences, Journal Year: 2022, Volume and Issue: 309, P. 120996 - 120996

Published: Sept. 25, 2022

Language: Английский

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Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 18, 2023

Background Silymarin is a polyphenolic flavonoid complex extricated from dried fruits and seeds of the plant Silybum marianum L. Chemically, it mixture flavonolignan complexes consisting silybin, isosilybin, silychristin, silydianin, minor quantity taxifolin, other compounds, which possess different bio medicinal values. Purpose This review critically looks into current status, pharmaceutical prospects limitations clinical application for treating neurological disorders. In particular, Silymarin’s properties molecular mechanisms are focused on providing better-compiled understanding helpful in its neuro-pharmacological or therapeutic aspects. Methods was compiled by literature search done using three databases, i.e., PubMed (Medline), EMBASE Science Direct, up to January 2023, keywords-Silymarin, disorders, cognitive Type 2 Diabetes, treatment. Then, potentially relevant publications studies (matching eligible criteria) were retrieved selected explain this PRISMA 2020 (Preferred Reporting Items Systematic Reviews Meta-Analyses) study flow chart. Result Since discovery, has been widely studied as hepatoprotective drug various liver However, last 10–15 years, several research have shown putative neuroprotective nature against brain including psychiatric, neurodegenerative, cognitive, metabolic The main underlying preventing curing such disorders antioxidant, anti-inflammatory, anti-apoptotic, pro-neurotrophic pro-estrogenic bioactive molecules. Conclusion provides lucid summary well-studied effects Silymarin, usage during Finally, we suggested future course action developing novel herbal treatment diseases.

Language: Английский

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A review of nanostructured delivery systems for the encapsulation, protection, and delivery of silymarin: An emerging nutraceutical

Food Research International, Journal Year: 2022, Volume and Issue: 156, P. 111314 - 111314

Published: April 29, 2022

Language: Английский

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Rationally designed nanoparticulate delivery approach for silymarin with natural bio-enhancer: In vitro characterization and in vivo evaluations of hepatoprotective effects in a mouse model

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 86, P. 104580 - 104580

Published: May 27, 2023

Language: Английский

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Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2606 - 2606

Published: March 13, 2023

The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is tablet. A versatile platform tablets available therapeutic agents to gastrointestinal tract. This study aimed prepare gastro retentive drug floating silymarin improve its oral bioavailability solubility. Hydroxypropyl methylcellulose (HPMCK4M HPMCK15), Carbopol 934p sodium bicarbonate were used as a matrix, enhancer gas generating agent, respectively. prepared evaluated physicochemical parameters such hardness, weight variation, friability, properties (floating lag time, total time), content, stability study, in vitro release, vivo behavior pharmacokinetics. drug-polymer interaction was studied by Differential Scanning Calorimetry (DSC) thermal analysis Fourier transform infrared (FTIR). time formulation within prescribed limit (<2 min). showed good matrix integrity retarded release >12 h. dissolution can be described zero-order kinetics (r2 = 0.979), with anomalous diffusion mechanism (n 0.65). An pharmacokinetic that Cmax AUC increased up two times comparison conventional dosage form. imaging tablet present stomach 12 It concluded from this combined system containing hydrophobic hydrophilic polymers min imized burst achieved kinetics, which practically difficult only matrix. elaborated solubility improved an mean residence time.

Language: Английский

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Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 7950 - 7950

Published: Dec. 5, 2023

Currently, skin injuries have a serious impact on people's lives and socio-economic stress. Shikonin, naphthoquinone compound derived from the root of traditional Chinese medicine has favorable biological activities such as anti-inflammatory, antibacterial, immunomodulatory, anticancer, wound-healing-promoting pharmacological activities. It been reported that Shikonin can be used for repairing diseases due to its wide range effects. Moreover, antimicrobial activity play great role in food also reduce number pathogenic bacteria food. This paper summarizes research effects recent years, well mechanism action treatment certain diseases, provide theoretical references clinical application provides ideas investigation other diseases.

Language: Английский

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Formulation and Evaluation of a Silymarin Inclusion Complex-Based Gel for Skin Cancer

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Silymarin (SLM) is a bioactive, water-insoluble flavonoid reported against different types of cancer. In the present research, SLM inclusion complex was prepared by freeze-drying method using cyclodextrins. The phase solubility study performed to assess stability constant and complexation efficiency. complexes (F1, F2, F3) were characterized for physicochemical in vitro parameters. Based on results, selected (F2) converted topical gel. Finally, it evaluated antioxidant, protein denaturation, cell viability assay (B16F10; skin cancer line). results further confirmed performing molecular docking study. solubilization showed formation stable with value 548 mol L–1 (βCD-PLX), 911 (HP βCD-PLX), 736 (M βCD-PLX). A marked increase release pattern found from (80.9 ± 2.2–97.8 3.1%) compared free (24.1 2.8%). DSC as well IR studies confirm complex. SEM X-ray diffraction conversion amorphous form. exhibited high score both colchicine-binding sites tubulin (−6.28 kcal/mol) complexing agents, viz., βCD (−4.61 kcal/mol), HP (−5.77 M (−5.61 kcal/mol). antioxidant that activity significantly improved (1.2–1.6 fold) SLM. outcome displayed concentration-dependent lower IC50 F2G2 (145.3 4.2 μg/mL) than (304.7 5.7 μg/mL). above conclusions demonstrated developed complex-based gel system could be an ideal delivery

Language: Английский

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Graphene-silymarin-loaded chitosan/gelatin/hyaluronic acid hybrid constructs for advanced full-thickness burn wound management

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124238 - 124238

Published: May 19, 2024

Language: Английский

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