Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels DOI Creative Commons
Yesica María Rodríguez-Cortés, Ricardo Jair Ramírez‐Carreto,

Julia Isabel Rodríguez-Barrena

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 18, 2024

Background Obesity is associated with a systemic inflammatory state that contributes to neuroinflammation and increases the risk of stroke at an early age. Stroke third leading cause death worldwide permanent disability. This work aimed assess whether obesity-induced can be prognostic factor improved oral administration silymarin, anti-inflammatory neuroprotective drug. Methods Male C57/Bl6 mice were used establish obesity model through high-fat diet (HFD) for 12 weeks. Cerebral ischemia was performed photothrombosis in left motor cortex end diet. Following induction ischemia, silymarin (100 mg/kg) administered orally 14 days. Levels pro-inflammatory (IL1β, TNFα, MCP1) markers (IL4, IL10), neurotrophic factors (IGF1, BDNF), CX3CL1 assessed striatum using ELISA. Results Mice on HFD gained significantly more weight than control subjects exhibited altered glucose metabolism, which after treatment. The survival rate lower (52.2%) compared (86%). Silymarin treatment both ischemic groups (non-diet control: 95.7%, HFD: 78.3%). raised cortical IL4, IL10, IGF1, BDNF, levels group stroke, while did not present relevant differences. Conclusion Our findings suggest improves possibly impacting post-stroke obese mice. increased BDNF along microglial regulatory CX3CL1, may contribute observed. These results indicate could potential therapeutic option managing enhancing outcomes individuals.

Language: Английский

Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial DOI Creative Commons
Aline Boveto Santamarina, Jéssica Alves de Freitas, Lucas Augusto Moysés Franco

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 15, 2024

Abstract Nutraceutical interventions supporting microbiota and eliciting clinical improvements in metabolic diseases have grown significantly. Chronic stress, gut dysbiosis, metainflammation emerged as key factors intertwined with sleep disorders, consequently exacerbating the decline quality of life. This study aimed to assess effects two nutraceutical formulations containing prebiotics (fructooligosaccharides (FOS), galactooligosaccharides (GOS), yeast β-glucans), minerals (Mg, Se, Zn), herbal medicine Silybum marianum L. Gaertn., Asteraceae (Milk thistle or Silymarin). These formulations, namely NSupple (without silymarin) NSupple_ (with were tested over 180 days overweight/obese volunteers from Brazil's southeastern region. We accessed fecal by partial 16S rRNA sequences; cytokines expression CBA; anthropometrics, life sleep, well hormonal parameters, at baseline (T0) (T180) post-supplementation. Results demonstrated reshaping phyla, genera, species level The Bacteroidetes phylum, Bacteroides , Prevotella genera positively modulated especially group. Gut modulation was associated improved patterns, quality-of-life perception, expression, anthropometric parameters Our findings suggest that blends enhance cardiometabolic inflammatory markers. Particularly, composition, underscoring its potential significance ameliorating dysregulation. Clinical trial registry number: NCT04810572. 23/03/2021.

Language: Английский

Citations

6
Dual role of the hyperaccumulator Silybum marianum (L.) Gaertn. in circular economy: Production of silymarin, a valuable secondary metabolite, and remediation of heavy metal contaminated soils DOI

Sotiria G. Papadimou,

Evangelia E. Golia,

Nikolaos Barbayiannis

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 38, P. 101454 - 101454

Published: Jan. 26, 2024

Language: Английский

Citations

5
Silibinin’s role in counteracting neuronal apoptosis and synaptic dysfunction in Alzheimer’s disease models DOI
Baohui Zhang, Di Zhang, Keyan Chen

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders DOI
Abdulmajeed G. Almutary, M. Yasmin Begum,

Ayesha Siddiqua

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats DOI
Roland Eghoghosoa Akhigbe, Adebayo Oluwafemi Adekunle, Moyosore Salihu Ajao

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151668 - 151668

Published: March 1, 2025

Language: Английский

Citations

0
Evaluating the Protective Effects of Silymarin Along with a Cholesterol-Supplemented Diet Against Demyelination in an EAE Mouse Model of Multiple Sclerosis: Lipidomic and Inflammatory Aspects DOI

Parvin Mosaddeghi,

Seyed Alireza Mesbah‐Namin, Mohammad Javan

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

0
Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats DOI Creative Commons

Dina Mohamed Mekawy,

Dina Sabry, Rania Mohamed Sabry

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: April 18, 2024

Abstract Background TGF-β1 and SMAD3 are particularly pathogenic in the progression of renal fibrosis. Aim This study aimed to evaluate kidney protective potentials silymarin (SM) exosomes mesenchymal stem cells against nephrotoxin thioacetamide (TAA) rats. Methods 32 female rats were randomly assigned into four groups: control group, TAA + SM Exosomes group. The homogenates from all groups examined for expression levels TGF-β receptors I II using real-time PCR, collagen type CTGF proteins ELISA, nuclear SMAD2/3/4, cytoplasmic SMAD2/3, SMAD4 western blot technique. Results Compared injection resulted a significant increase serum urea creatinine, gene TβRI TβRII, protein both proteins, SMAD2/3 complex, SMAD2/3/4 (p-value < 0.0001), with significantly decreased co-SMAD partner, 0.0001). Those effects reversed considerably treatment groups, superiority exosomal regarding SMAD gene, I, returning near-control values > 0.05). Conclusion Using vitro vivo experimental approaches, research discovered reno-protective role BM-MSCs after thioacetamide-induced fibrosis rats, advantage exosomes.

Language: Английский

Citations

3
Assessing the influence of micelle silymarin on laying hens' performance, egg quality, water loss and blood profile DOI
Golam Sagir Ahammad,

Yong Hwee Jeon,

In Ho Kim

et al.

Journal of Animal Physiology and Animal Nutrition, Journal Year: 2024, Volume and Issue: 108(5), P. 1326 - 1335

Published: April 29, 2024

Micelle silymarin (MS) is known for its various beneficial properties, including antiswelling, antioxidant, hepatoprotective and antidiabetic effects. The primary goal of this research was to investigate how MS impacts the performance, egg quality, water loss blood profile laying hens. 288 Hy-Line brown hens, 28 weeks in age, were utilized experiment. hens randomly allocated into three dietary treatment groups, with each group comprising eight replicates 12 housed individual pens access feed water. Over a 12-week feeding trial, provided basal diet supplemented different levels MS: 0%, 0.03% 0.06%. results indicated that inclusion hens' did not have significant impact on their performance (p > 0.05). However, Haugh units, weight eggshell strength showed linear improvement < 0.05) throughout entire trial period supplementation. Furthermore, there decrease yolk colour thickness improvements 0.05), particularly during Week 8, Moreover, layers fed increased albumen height 12. In addition, 12, third day incubation, linearly decreased as an effect increasing level hen's Regarding parameters, study revealed tendency alkaline phosphatase decrease, whereas aspartate aminotransferase cholesterol summary, supplementation appeared be improving slight certain aspects without adversely affecting growth performance.

Language: Английский

Citations

2
Silymarin Supplementation in Active Rheumatoid Arthritis: Outcomes of a Pilot Randomized Controlled Clinical Study DOI Creative Commons

G. Zugravu,

Carmen Pintilescu,

Carmen Marinela Cumpăt

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 999 - 999

Published: June 18, 2024

Background and Objectives: Coadministration of natural products to enhance the potency conventional antirheumatic treatment is high interest. This study aimed assess impact administration silymarin (a nutritional supplement) in patients with active rheumatoid arthritis under disease-modifying drugs. Materials Methods: One-hundred twenty-two diagnosed treated drugs were randomly assigned either control or intervention groups; latter was supplemented (300 mg/day) for 8 weeks. Indicators disease activity, inflammatory markers, activity disability indices, European League Against Rheumatism responses, fatigue, depression, anxiety scores determined at baseline week 8. Results: Silymarin supplementation significantly reduced number tender swollen joints, duration morning stiffness, severity pain, levels anxiety. According our results, substantially improved patients’ general condition. Conclusions: Our provides evidence benefits arthritis.

Language: Английский

Citations

2
Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders DOI Creative Commons

Soumili Biswas,

P. D. Patil,

Shovit Ranjan

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2024, Volume and Issue: 7, P. 100069 - 100069

Published: July 1, 2024

This comprehensive review delves into the potential therapeutic efficacy of dioscin and diosgenin, phytocompounds extracted from Dioscoreaceae family, in alleviating neurological disorders. The article meticulously elucidates putative neuroprotective mechanisms diosgenin various disorders, emphasizing their ability to mitigate cognitive impairments, diminish neuropathological hallmarks, suppress neuroinflammatory responses. A detailed discussion pharmacokinetic profiles encompassing distribution bioavailability following administration, is also presented. Additionally, paper outlines challenges prospective directions translating preclinical findings about clinically relevant applications, underscoring need for more rigorous clinical trials standardized formulations. summary accurately captures key highlights these natural compounds' treating conditions.

Language: Английский

Citations

2