Cited by In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using Intranasal Route

Unravelling the in vivo dynamics of liposomes: Insights into biodistribution and cellular membrane interactions DOI

Sharanya Paramshetti, Mohit Angolkar, Sirajunisa Talath

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122616 - 122616

Published: April 8, 2024

Language: Английский

Citations

Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport DOI

Shivani Gandhi, Divyesh H. Shastri, Jigar Shah

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 481 - 481

Published: April 1, 2024

The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome the challenges associated with conventional drug administration for central nervous disorders. This emerging field is driven by anatomical advantages of nasal route, enabling direct transport drugs from cavity brain, thereby circumventing blood–brain barrier. review highlights significance features cavity, emphasizing its high permeability and rich blood supply that facilitate rapid absorption onset action, rendering it domain neurological therapeutics. Exploring recent developments innovations in different nanocarriers such liposomes, polymeric nanoparticles, solid lipid dendrimers, micelles, nanoemulsions, nanosuspensions, carbon nanotubes, mesoporous silica nanogels unveils their diverse functions improving efficiency targeting specificity within this system. To minimize potential risk nanoparticle-induced toxicity mucosa, article also delves into latest advancements formulation strategies commonly involving surface modifications, incorporating cutting-edge materials, adjustment particle properties, development novel formulations improve stability, release kinetics, specificity. These approaches aim enhance while minimizing adverse effects. hold catalyze advancement safer more efficient systems, consequently revolutionizing treatments provides valuable resource researchers, clinicians, pharmaceutical-industry professionals seeking advance effective safe therapies

Language: Английский

Citations

Exploring the impact of physicochemical properties of liposomal formulations on their in vivo fate DOI

Behjat Sheikholeslami,

Nga Wing Lam,

Kamal Dua

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 300, P. 120574 - 120574

Published: April 23, 2022

Language: Английский

Citations

Brain targeted delivery of carmustine using chitosan coated nanoparticles via nasal route for glioblastoma treatment DOI

Saeem Ahmad, Iram Khan,

Jayamanti Pandit

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 221, P. 435 - 445

Published: Sept. 5, 2022

Language: Английский

Citations

Nose to brain delivery of donepezil through surface modified NLCs: Formulation development, optimization, and brain targeting study DOI

Mohd Yasir,

Ameeduzzafar Zafar,

K.M. Noorulla

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 75, P. 103631 - 103631

Published: July 31, 2022

Language: Английский

Citations

Biopolymer Nanoparticles for Nose-to-Brain Drug Delivery: A New Promising Approach for the Treatment of Neurological Diseases DOI

Nicolò Montegiove, Eleonora Calzoni, Carla Emiliani

et al.

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(3), P. 125 - 125

Published: Aug. 24, 2022

Diseases affecting the central nervous system (CNS) are among most disabling and difficult to cure due presence of blood–brain barrier (BBB) which represents an impediment from a therapeutic diagnostic point view as it limits entry drugs. The use biocompatible polymer nanoparticles (NPs) vehicles for targeted drug delivery brain arouses increasing interest. However, route administration these vectors remains critical must be delivered without being degraded achieve effect. An innovative approach drugs using polymeric carriers is represented by nose-to-brain (NtB) involves molecule through neuro-olfactory epithelium nasal mucosa. Nasal non-invasive that allows rapid transport directly minimizes its systemic exposure. To date, many studies involve NPs NtB treatment whole series neurological diseases which, today, there no cure. In this review, various types biodegradable discussed particular attention devoted such Glioblastoma neurodegenerative diseases.

Language: Английский

Citations

Nose-to-brain/spinal cord delivery kinetics of liposomes with different surface properties DOI

Takumi Kurano, Takanori Kanazawa,

Aoi Ooba

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 344, P. 225 - 234

Published: March 14, 2022

Language: Английский

Citations

Thymoquinone-Enriched Naringenin-Loaded Nanostructured Lipid Carrier for Brain Delivery via Nasal Route: In Vitro Prospect and In Vivo Therapeutic Efficacy for the Treatment of Depression DOI

Farheen Fatima Qizilbash,

Muhammad Usama Ashhar,

Ameeduzzafar Zafar

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 656 - 656

Published: March 16, 2022

In the current research, a thymoquinone-enriched naringenin (NGN)-loaded nanostructured lipid carrier (NLC) was developed and delivered via nasal route for depression. Thymoquinone (TQ) oil used as liquid provided synergistic effects. A TQ- NGN-enriched NLC ultrasonication technique optimized using central composite rotatable design (CCRD). The exhibited following properties: droplet size, 84.17 to 86.71 nm; PDI, 0.258 0.271; zeta potential, -8.15 -8.21 mV; % EE, 87.58 88.21%. in vitro drug release profile showed supremacy of TQ-NGN-NLC comparison NGN suspension, with cumulative 82.42 ± 1.88% from 38.20 0.82% suspension. Ex vivo permeation study displayed 2.21-fold increase compared DPPH better antioxidant potential alone due effect TQ oil. CLSM images revealed deeper NGN-NLC (39.9 µm) through mucosa suspension (20 µm). Pharmacodynamic studies, such forced swim test locomotor activity test, were assessed depressed rat model, which remarkable antidepressant marketed formulation. results signify TQ-enriched enhancing brain delivery therapeutic depression treatment.

Language: Английский

Citations

Brain targeting of cefepime loaded transfersomes based thermosensitive in situ gel via intranasal delivery: In vitro and in vivo studies DOI

Rashna Mirza,

Ashraf Ullah Khan, Kifayat Ullah Shah

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105585 - 105585

Published: March 15, 2024

Language: Английский

Citations

A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting DOI

Naeem Mubarak, Muhammad Ahsan Waqar,

Asad Majeed Khan

et al.

Designed Monomers & Polymers, Journal Year: 2025, Volume and Issue: 28(1), P. 7 - 29

Published: Feb. 10, 2025

Central Nervous System (CNS) disorders are the leading cause of illness and affect everyday lives people all around globe predicted to increase tremendously in upcoming decades. Traditional methods delivering drugs CNS face considerable limitations. Nose-to-brain targeting offers a promising alternative that bypasses blood-brain barrier (BBB), enabling targeted drug administration central nervous system (CNS). Nanotechnology has brought forward innovative solutions challenges delivery disorders. Nanocarriers such as liposomes, nanoparticles, nanoemulsions dendrimers can enhance stability, bioavailability, brain. These nanocarriers designed overcome physiological barriers provide controlled sustained release directly CNS. Nanocarrier technology made significant strides recent years, more effective With advancements, intranasal coupled with seems be combination better clinical profiles, pharmacokinetics, pharmacodynamics for neurodegenerative This study focuses on exploring nose-to-brain system, emphasizing use various this purpose. Additionally, encompasses advancements nanocarrier tailored specifically improve efficiency through nasal route

Language: Английский

Citations