Exploring Elastic Lipid Nanovesicles for Enhanced Skin Permeation of Whole Plant Extract: A Comprehensive Investigation
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Journal Year:
2025,
Volume and Issue:
113(1)
Published: Jan. 1, 2025
A
new
method
is
developed
using
elastic
lipid
nanovesicles
(ELNs)
loaded
with
ethanolic
extract
of
Lantana
camara
(LC)
to
enhance
skin
permeation
plant
actives.
The
ELNs
contained
cholesterol,
1,
2-distearoyl-sn-glycero-3-phosphocholine,
span
80,
and
tween
80.
Firstly,
15
formulations
were
produced
examine
critical
factors
likely
affecting
formulation
characteristics.
In
addition,
surface
characteristics,
vesicle
size,
polydispersity
index,
zeta
potential,
degree
deformability,
%
entrapment
efficiency
(%
EE)
ELN
examined.
As
a
significant
parameter,
was
measured
(using
Start-M;
it
highly
resembles
human
skin).
influence
hydrophilic-lipophilic
balance
(HLB),
ratio
vital
through
Start-M.
particular,
the
LC
decreased
at
more
extensive
size
ranges,
400,
350-450
nm.
contrast,
increased
significantly
smaller
such
as
200
100
More
than
75%
permeated
within
8
h
when
surfactant
(span
80:tween
80;
25%:75%).
Permeation
studies
conducted
based
on
HLB
values
revealed
that
78%
in
12.2,
an
increase
HLB.
Cell
viability
assay
SK-MEL-37
cells
(skin
cancer)
reduced
by
~80%
24
h,
further
validating
formulation.
Future
research
could
investigate
long-term
safety
therapeutic
potential
these
clinical
settings
their
effectiveness
delivering
other
plant-based
extracts
for
transdermal
applications
via
ELNs.
Language: Английский
Anticancer Properties of Some Selected Plant Phenolic Compounds: Future Leads for Therapeutic Development
Journal of Herbal Medicine,
Journal Year:
2023,
Volume and Issue:
42, P. 100801 - 100801
Published: Oct. 17, 2023
Language: Английский
New insights in aptamer-targeted nanoliposomes for the treatment of breast cancer
Journal of Drug Delivery Science and Technology,
Journal Year:
2023,
Volume and Issue:
87, P. 104880 - 104880
Published: Aug. 26, 2023
Language: Английский
Lab on chip based self-adjustable liposomes for rapid wound healing: An in depth in vitro, in vivo and higher dose toxicity investigation
Rahul Maheshwari,
No information about this author
Piyush Ghode,
No information about this author
Mayank Sharma
No information about this author
et al.
Biomaterials Advances,
Journal Year:
2024,
Volume and Issue:
158, P. 213777 - 213777
Published: Jan. 19, 2024
Language: Английский
Photoresponsive ‘Chemo-Free’ Phytotherapy: Formulation Development For the Treatment of Triple-Negative Breast Cancer
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(1), P. 5 - 24
Published: Jan. 1, 2024
Aim:
The
present
investigation
aimed
to
develop
a
chemo-free,
nanophytosomal
system
treat
triple-negative
breast
cancer
(TNBC)
via
phyto–photo
dual
treatment
strategy.
Method:
Size,
shape,
surface
analysis,
photoprovoked
release
profile,
photothermal
stability,
(3-(4,
5-dimethylthiazolyl-2)-2,
5-diphenyltetrazolium
bromide
assay,
apoptotic
DNA
fragmentation,
in
vitro
cellular
uptake
evaluation,
mitochondrial
membrane
potential
and
caspase-3
photodynamic
evaluation.
Results:
Biological
experiments
using
MDA-MB-231
cells
displayed
dose-dependent
synergistic
anti-TNBC
activity
of
PhytoS/Houttuynia
cordata
extract
(HCE)/IR780
as
compared
with
Phyto/HCE,
PhytoS/IR780
even
more
promising
under
laser
treatment.
Apoptotic
assay
fragmentation
analysis
also
showed
enhanced
effects.
Investigation
found
that
HCE
acts
suppression
inducing
cells.
Conclusion:
Our
findings
suggested
photo-empowered
phytotherapy
can
be
employed
effectively
safely
against
TNBC.
Language: Английский