Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 187 - 187

Published: Jan. 15, 2024

In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize

Language: Английский

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Targeting triple negative breast cancer stem cells using nanocarriers

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 7, 2024

Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract

Language: Английский

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Polymer mediated light responsive therapeutics delivery system to treat cancer

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112923 - 112923

Published: March 12, 2024

Language: Английский

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Metallic nanoparticles in cancer: Types, green synthesis, applications, tumor microenvironment and toxicity considerations

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 92, P. 105307 - 105307

Published: Dec. 29, 2023

Language: Английский

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Improving synthesis and binding affinities of nucleic acid aptamers and their therapeutics and diagnostic applications

Biophysical Chemistry, Journal Year: 2024, Volume and Issue: 309, P. 107218 - 107218

Published: March 21, 2024

Language: Английский

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Lab on chip based self-adjustable liposomes for rapid wound healing: An in depth in vitro, in vivo and higher dose toxicity investigation

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 158, P. 213777 - 213777

Published: Jan. 19, 2024

Language: Английский

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Recent advancements in aptamers as promising nanotool for therapeutic and diagnostic applications

Analytical Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 115844 - 115844

Published: March 1, 2025

Language: Английский

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Emerging Biopolymer Nanocarriers for Controlled and Protective Delivery of Food Bioactive Compounds- Current Status and Future Perspective

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 160, P. 110769 - 110769

Published: Oct. 22, 2024

Language: Английский

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Niosomes based formulation containing tenoxicam: A newer solution for the rheumatic diseases

Annales Pharmaceutiques Françaises, Journal Year: 2023, Volume and Issue: 82(3), P. 473 - 482

Published: Nov. 3, 2023

Language: Английский

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Photoresponsive ‘Chemo-Free’ Phytotherapy: Formulation Development For the Treatment of Triple-Negative Breast Cancer

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(1), P. 5 - 24

Published: Jan. 1, 2024

Aim: The present investigation aimed to develop a chemo-free, nanophytosomal system treat triple-negative breast cancer (TNBC) via phyto–photo dual treatment strategy. Method: Size, shape, surface analysis, photoprovoked release profile, photothermal stability, (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay, apoptotic DNA fragmentation, in vitro cellular uptake evaluation, mitochondrial membrane potential and caspase-3 photodynamic evaluation. Results: Biological experiments using MDA-MB-231 cells displayed dose-dependent synergistic anti-TNBC activity of PhytoS/Houttuynia cordata extract (HCE)/IR780 as compared with Phyto/HCE, PhytoS/IR780 even more promising under laser treatment. Apoptotic assay fragmentation analysis also showed enhanced effects. Investigation found that HCE acts suppression inducing cells. Conclusion: Our findings suggested photo-empowered phytotherapy can be employed effectively safely against TNBC.

Language: Английский

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