Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 765 - 765
Published: June 4, 2024
Nanoliposomes
are
nano-sized
vesicles
that
can
be
used
as
drug
delivery
carriers
with
the
ability
to
encapsulate
both
hydrophobic
and
hydrophilic
compounds.
Moreover,
their
lipid
compositions
facilitate
internalization
by
cells.
However,
interaction
between
nanoliposomes
membrane
barrier
of
human
body
is
not
well-known.
If
cellular
tests
animal
testing
offer
a
solution,
lack
physiological
relevance
ethical
concerns
make
them
unsuitable
properly
mimic
complexity.
Microfluidics,
which
allows
environment
imitated
in
controlled
way,
fulfil
this
role.
existing
models
missing
presence
something
would
basal
membrane,
often
consisting
simple
cell
layer
on
polymer
membrane.
In
study,
we
investigated
diffusion
microfluidic
system
found
optimal
parameters
maximize
diffusion.
Then,
incorporated
custom
made
GelMA
degree
substitution
studied
passage
fluorescently
labeled
through
barrier.
Our
results
show
highly
substituted
was
more
porous
than
lower
GelMA.
Overall,
our
work
lays
foundation
for
incorporation
hydrogel
mimicking
platform.
Processes,
Journal Year:
2023,
Volume and Issue:
11(3), P. 922 - 922
Published: March 17, 2023
In
the
present
study,
electrochemical
behavior
of
antiviral
drug
umifenovir
(Umi)
and
encapsulated
in
phospholipids
micelles
(nanosome/umifenovir,
NUmi)
were
investigated
for
first
time
on
screen-printed
electrodes
modified
by
carbon
nanotubes.
We
have
shown
that
Umi
can
be
electro
oxidized
around
potential
+0.4
V
concentration
range
50–500
µM
(R2
=
0.992).
Non-overlapping
signatures
DNA
(10–150
µM)
permit
to
register
interaction
between
(or
micelles),
purine,
pyrimidine
heterocyclic
bases
separately.
The
type
is
most
likely
via
electrostatic
interactions
groove
binding
drug-DNA
formed
complex,
as
was
revealed
based
values
constants
Kb
cathodic
shifts
oxidation
potentials
with
increasing
or
NUmi
concentration.
negative
Gibbs
free
energy
(ΔG)
all
nucleobases
confirm
process
spontaneity.
This
study
one
presenting
effect
dsDNA
a
target
pharmacogenomics.
Translational Oncology,
Journal Year:
2023,
Volume and Issue:
39, P. 101838 - 101838
Published: Nov. 27, 2023
As
a
clinically
approved
treatment
strategy,
chemotherapy-mediated
tumor
suppression
has
been
compromised,
and
in
spite
of
introducing
various
kinds
anticancer
drugs,
cancer
eradication
with
chemotherapy
is
still
impossible.
Chemotherapy
drugs
have
beneficial
improving
the
prognosis
patients,
but
after
resistance
emerged,
their
potential
disappeared.
Oxaliplatin
(OXA)
efficacy
compromised
by
resistance.
Due
to
dysregulation
pathways
mechanisms
OXA
resistance,
it
suggested
develop
novel
strategies
for
overcoming
drug
The
targeted
delivery
nanostructures
described
here.
can
be
mediated
polymeric,
metal,
lipid
carbon
nanostructures.
advantageous
these
nanocarriers
that
they
enhance
accumulation
promote
its
cytotoxicity.
Moreover,
(nano)platforms
mediate
co-delivery
genes
synergistic
therapy,
insights
patient
future.
smart
nanostructures,
including
pH-,
redox-,
light-,
thermo-sensitive
designed
therapy.
application
nanoparticle-mediated
phototherapy
increase
OXA's
suppression.
All
subjects
clinical
implications
are
discussed
current
review.
Journal of Applied Polymer Science,
Journal Year:
2024,
Volume and Issue:
141(34)
Published: June 6, 2024
Abstract
In
order
to
obtain
a
kind
of
anticancer
drug
delivery
carriers
with
good
stability
in
blood
circulation,
high
cellular
uptake,
and
controlled
release
ability,
folate‐modified
polyurethane
disulfide
bonds
amino
groups
(FPUSN)
carboxyl
(PUC)
were
respectively
synthesized.
FPUSN
PUC
could
co‐assemble
water
form
nanomicelles
(FPUSN/PUC)
via
electrostatic
interaction.
When
the
mass
ratio
was
12,
FPUSN/PUC‐12
micelles
had
obvious
negative‐to‐positive
charge‐reversal
property
decreasing
pH
from
7.4
5.0.
Doxorubicin‐loaded
(FPUSN/PUC‐12@DOX)
negative
charges
showed
excellent
under
simulated
normal
physiological
condition.
However,
happened
at
6.5
positive
increased
decrease.
glutathione
concentration
10
mM,
structure
FPUSN/PUC‐12@DOX
broken.
So
exhibited
significant
acid/reduction‐sensitive
properties
then
DOX
be
rapidly
released
tumor
intracellular
environment.
Cellular
experimental
results
demonstrated
that
enhance
uptake
acid
condition
better
anti‐proliferation
effect
against
HGC‐27
cells
than
owing
multi‐responsive
synergistic
effects.
Therefore,
FPUSN/PUC
will
have
great
application
potential
as
for
enhancing
efficacy.
Advanced Pharmaceutical Bulletin,
Journal Year:
2024,
Volume and Issue:
14(3), P. 513 - 523
Published: July 31, 2024
Liver
cancer,
specifically
hepatocellular
carcinoma
(HCC),
is
the
second
leading
cause
of
cancer-related
deaths,
following
pancreatic
cancer.
The
5-year
overall
survival
rate
for
HCC
remains
relatively
low.
Currently,
there
are
multiple
treatment
options
available
HCC,
including
systemic
drugs,
minimally
invasive
local
therapies
such
as
radiofrequency
ablation,
transarterial
chemoembolization
(TACE),
and
arterial
radioembolization
(TARE),
well
surgical
interventions
like
liver
resection
or
transplantation.
However,
effectiveness
drug
delivery
to
cancerous
hindered
by
pathophysiological
changes
in
organ.
In
order
address
this
challenge,
lipid-based
nanoparticles
(LNPs)
have
emerged
promising
platforms
delivering
a
diverse
range
therapeutic
drugs.
LNPs
offer
various
structural
configurations
that
enhance
their
physical
stability
enable
them
accommodate
different
types
cargo
with
varying
mechanical
properties
degrees
hydrophobicity.
article,
we
provide
comprehensive
review
current
applications
development
anti-HCC
therapies.
By
examining
existing
research,
aim
shed
light
on
potential
future
directions
advancements
field.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 765 - 765
Published: June 4, 2024
Nanoliposomes
are
nano-sized
vesicles
that
can
be
used
as
drug
delivery
carriers
with
the
ability
to
encapsulate
both
hydrophobic
and
hydrophilic
compounds.
Moreover,
their
lipid
compositions
facilitate
internalization
by
cells.
However,
interaction
between
nanoliposomes
membrane
barrier
of
human
body
is
not
well-known.
If
cellular
tests
animal
testing
offer
a
solution,
lack
physiological
relevance
ethical
concerns
make
them
unsuitable
properly
mimic
complexity.
Microfluidics,
which
allows
environment
imitated
in
controlled
way,
fulfil
this
role.
existing
models
missing
presence
something
would
basal
membrane,
often
consisting
simple
cell
layer
on
polymer
membrane.
In
study,
we
investigated
diffusion
microfluidic
system
found
optimal
parameters
maximize
diffusion.
Then,
incorporated
custom
made
GelMA
degree
substitution
studied
passage
fluorescently
labeled
through
barrier.
Our
results
show
highly
substituted
was
more
porous
than
lower
GelMA.
Overall,
our
work
lays
foundation
for
incorporation
hydrogel
mimicking
platform.
