Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 31, 2025

Despite the diverse applications of γ radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, mitochondrial dysfunction. This study evaluated efficacy curcumin nanoparticles (CNPs) mitigating dysfunction senescence induced by rat brain tissues. Four groups male Wistar albino rats (n = 8 per group) were included: (Gr1) control group; (Gr2) CNPs group (healthy receiving oral administration at a dose 10 mg/kg/day, three times week for eight weeks); (Gr3) irradiated (rats exposed to single Gy head irradiation); (Gr4) + (irradiated treated with CNPs). The data obtained demonstrated that weeks attenuated oxidative stress γ-irradiated lowering brain's lipid peroxidation level [malondialdehyde (MDA)] enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), total capacity (TAC)] (P < 0.05). In addition, significantly increased function improving complex I, II, ATP production levels compared group. rats, also showed anti-neuroinflammatory reducing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), nuclear factor-kappa B (NF-ĸB) Moreover, administered β-galactosidase activity expression p53, p21, p16 genes 0.05) while concurrently inducing significant increase AMPK mRNA conclusion, ameliorated neurotoxicity hold promise novel agent delay via their combined antioxidant, anti-inflammatory, mitochondrial-enhancing properties.

Language: Английский

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Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102393 - 102393

Published: June 24, 2024

Language: Английский

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Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154986 - 154986

Published: July 21, 2023

Language: Английский

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Development of mucoadhesive methacrylic anhydride-modified hydroxypropyl methylcellulose hydrogels for topical ocular drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105450 - 105450

Published: Feb. 3, 2024

Language: Английский

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Construction of quaternary ammonium chitosan-coated protein nanoparticles as novel delivery system for curcumin: Characterization, stability, antioxidant activity and bio-accessibility

Food Chemistry, Journal Year: 2024, Volume and Issue: 455, P. 139923 - 139923

Published: May 31, 2024

Language: Английский

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Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141193 - 141193

Published: Sept. 11, 2024

Language: Английский

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Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(14), P. 17080 - 17091

Published: April 1, 2024

Psoriasis is a systemic, recurrent, chronic autoimmune skin disease. However, psoriasis drugs have poor permeability and high toxicity, resulting in low bioavailability affecting their clinical application. In this study, we propose curcumin-based ionic liquid hydrogel loaded with ilomastat (Cur-Car-IL@Ilo hydrogel), which can effectively maintain the sustained release of improve drugs. We used model imiquimod-induced demonstrated that local application Cur-Car-IL@Ilo lesions mice significantly reduced expression levels inflammatory factors, matrix metalloproteinase 8, collagen-I. The expressions iron death-related proteins SLC7A11 ASL4 were decreased after treatment hydrogel. Flora analysis showed content anaerotruncus, proteus, UCG-009 bacteria gut psoriatic increased. paludicola, parabacteroides, prevotellaceae_UCG-001, escherichia-shigella, aerococcus decreased, some above tended to be normal treatment. Therefore, as multifunctional, nonirritating, noninvasive, highly effective percutaneous psoriasis.

Language: Английский

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Curcuma Longa: Nutraceutical Use and Association With Nanotechnology

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 7, 2024

Curcumin is a natural product found in the rhizome of Curcuma longa (L.) and other spp. As lipophilic molecule, it has greater affinity for polar, non-polar, alkaline, or extremely acidic organic solvents. Several studies indicate that curcumin several benefits human health, example, against degenerative diseases, cancer, infectious diseases. To obtain quality with nutraceutical properties, necessary to know its physicochemical characteristics preserve from cultivation until ingestion by human. However, low solubility leads absorption; this context, nanotechnological systems can contribute increase bioavailability. This review aims highlight important issues all stages goes through: aspects related extraction association nanotechnology. Although process already well established, possible observe more research focused on increasing yield being environmentally friendly. Further, curcumin's absorption notable due characteristics, mainly aqueous solubility. nanotechnology shows be promising an increasingly growing trend because use "Indian solid gold" hope many patients.

Language: Английский

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Curcumin-loaded food-grade nano-silica hybrid material exhibiting improved photodynamic effect and its application for the preservation of small yellow croaker (Larimichthys polyactis)

Food Research International, Journal Year: 2024, Volume and Issue: 188, P. 114492 - 114492

Published: May 10, 2024

Language: Английский

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Recent nanotechnology improvements in Curcumin bioavailability and related applications

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104660 - 104660

Published: July 2, 2024

Language: Английский

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