Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(6), P. 3565 - 3584
Published: Nov. 28, 2023
Language: Английский
OpenNano, Journal Year: 2023, Volume and Issue: 13, P. 100177 - 100177
Published: July 24, 2023
Gemcitabine (GEM) is a chemotherapeutic drug widely used for treating pancreatic cancer and other cancers. Despite its efficacy, GEM associated with adverse side effects tumor resistance, hampering therapeutic outcomes. To address these challenges, innovative strategies have emerged to enhance delivery. This comprehensive review explores various distribution systems, including polymer-based platforms, liposomes, inorganic nanoparticles, highlighting their unique characteristics improving efficacy in treatment. Additionally, we discuss the promising approach of codelivery genes present several methods augmenting GEM's properties. Our findings shed light on novel insights provide recommendations overcoming limitations GEM, guiding researchers clinicians toward more effective therapies.
Language: Английский
Citations
9
Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(17), P. 3869 - 3885
Published: Jan. 26, 2024
Language: Английский
Citations
3
Journal of Liposome Research, Journal Year: 2024, Volume and Issue: 34(4), P. 671 - 696
Published: March 23, 2024
Triple-negative breast Cancer (TNBC) is one of the deadliest types, making up about 20% all cancers. Chemotherapy traditional manner progressed TNBC treatment; however, it has a short-term result with high reversibility pace. The lack targeted treatment limited and person-dependent options for those suffering from cautions to be worst type cancer among patients. Consequently, appropriate this disease considered major clinical challenge. Therefore, various methods have been developed treat TNBC, which chemotherapy most common well-known approach recently studied. Although effective are chemotherapies, they often accompanied by critical limitations, especially specific functionality. These lead systematic toxicity and, ultimately, expansion multidrug-resistant (MDR) cells. finding novel efficient techniques enhance targeting an essential requirement. Liposomes demonstrated that method drug delivery; large number liposome-based delivery systems annually developed, small just received authorization application. new approaches using liposomes target their structure ligands increase therapeutic efficiency diminish undesired side effects on body tissues. current study describes recent strategies research associated functionalizing liposomes' different as carriers in treating TNBCs preclinical stages.
Language: Английский
Citations
3
Journal of the Chinese Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 16, 2024
Abstract Metal nanoparticles (NPs) have emerged as crucial components in precision drug delivery, presenting innovative opportunities to significantly enhance therapeutic efficacy and targeting accuracy. This review investigates recent developments the engineering of metal NPs, emphasizing their distinctive properties novel applications delivery systems. A comprehensive analysis is performed on gold, silver, iron, zinc oxide exceptional physicochemical enhanced drug‐loading capacities. These features collectively enable development implementation targeted controlled systems, indicating a new era advanced approaches. article accomplishes this by reflecting transformative potential envisioning heightened efficacy, minimized side effects, improved patient outcomes within dynamic landscape platforms.
Language: Английский
Citations
3
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(6), P. 3565 - 3584
Published: Nov. 28, 2023
Language: Английский
Citations
7