Archiv Euromedica,
Journal Year:
2023,
Volume and Issue:
13(6)
Published: Dec. 27, 2023
Purpose
of
the
Study:
To
analyze
effectiveness
using
sodium
deoxyribonucleate
(SDN)
for
pelvic
adhesions
in
rats
experiment.
Materials
and
Methods:
The
experiment
was
carried
out
on
90
laboratory
rats.
Three
groups
30
animals
each
were
formed:
group
1
–
control;
2
with
a
simulated
adhesive
process
pelvis
without
subsequent
treatment;
3
model
receiving
intramuscular
SDN
10
days.
modeled
by
ligating
uterine
horns
both
sides.
expression
CD4,
CD8,
CD20,
CD138
studied
DP-SOFT
software
program
statistical
processing.
Results:
In
control
group,
small
number
cells
CD4+,
CD8+
markers
found
parietal
peritoneum
(PP).
perimetrium
(PM),
no
positively
stained
immunophenotype
found.
2,
showed
an
increase
PP
expressing
CD4+
CD138+,
appearance
CD56+
cells.
An
CD138+
rats’
PM.
3,
compared
to
control,
count
cells,
significantly
increased.
PM
operated
animals,
we
rats,
noted,
which
indicates
activation
humoral
immune
system.
increased
control.
characterized
similar
distribution
Conclusion:
After
surgery,
causes
change
ratio
leukocyte
subpopulations
affected
area
towards
their
rather
than
perimetrium.
use
has
immunomodulatory
effect
stimulates
responses
increasing
immunocompetent
surgical
site.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(21)
Published: Jan. 28, 2024
Abstract
Abdominal
and
intrauterine
adhesions
are
common
postoperative
problems
that
can
cause
serious
complications.
Current
adhesives
usually
double
sided
suffer
from
poor
wet
adhesion,
nondegradability,
monofunctionality,
which
limits
their
application
in
preventing
adhesions.
Herein,
a
bioinspired
microstructured
Janus
bioadhesive,
named
OD/GM@PG,
with
adhesive
inner
layer
an
antiadhesive
outer
is
prepared
by
combining
electrostatic
spun
materials.
By
using
both
capillary
suction
catechol‐based
strategy,
the
strength
interfacial
toughness
of
bioadhesive
reach
98
kPa
325
J
m
−2
,
respectively,
much
higher
than
those
commercial
fibrin
glues
cyanoacrylate
glues.
The
acts
as
physical
barrier
friction‐reducing
effects.
Additionally,
demonstrates
biodegradable,
hemostatic,
antioxidative,
anti‐inflammatory,
prohealing
properties.
In
vivo
results
show
asymmetric
adhesion
effect
effectively
abdominal
Notably,
tandem
mass
tags‐labeled
quantitative
proteomics
analysis
demonstrate
expression
inflammatory
response‐associated
proteins
(S100A8,
S100A9)
associated
adhesion;
significantly
downregulates
this
expression.
Therefore,
OD/GM@PG
promising
candidate
for
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 188 - 188
Published: March 8, 2025
Postoperative
adhesions
are
common
complications
following
surgery,
often
accompanied
by
pain
and
inflammation
that
significantly
diminish
patients’
quality
of
life.
Moreover,
managing
postoperative
incurs
substantial
cost,
imposing
a
considerable
financial
burden
on
both
patients
healthcare
systems.
Traditional
anti-adhesion
materials
confronted
with
limitations,
such
as
inadequate
tissue
adherence
in
moist
environment
poor
degradability,
underscoring
the
urgent
need
for
more
effective
solutions.
Recently,
polysaccharide-based
hydrogels
have
received
attention
their
potential
preventing
adhesions.
The
not
only
facilitate
wound
healing
but
also
effectively
reduce
inflammation,
providing
promising
approach
to
This
review
provides
an
extensive
analysis
progress
made
development
therapy.
It
highlights
principal
benefits,
outlines
future
research
trajectories,
addresses
ongoing
challenges
be
overcome.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(2), P. 1031 - 1039
Published: Jan. 12, 2024
Surgical
bleeding
and
cumulative
oxidative
stress
are
significant
factors
in
the
development
of
postoperative
adhesions,
which
always
associated
with
adverse
patient
outcomes.
However,
effective
strategies
for
adhesion
prevention
currently
lacking
clinical
practice.
In
this
study,
we
propose
a
solution
using
polydopamine-decorated
manganese
dioxide
nanoparticles
(MnO2@PDA)
rapid
hemostasis
remarkable
antioxidant
properties
to
prevent
postsurgical
adhesion.
The
PDA
modification
provides
MnO2@PDA
enhanced
tissue
adhesiveness
hemocompatibility
negligible
hemolysis.
Furthermore,
exhibits
impressive
free
radical
scavenging
properties,
protecting
cells
from
negative
effects
stress.
hemostatic
activity
is
evaluated
mouse
truncated
tail
model
liver
injury
model,
results
demonstrating
reduced
time
volume.
vivo
test
on
cecal
abrasion
shows
that
excellent
antiadhesion
coupled
alleviated
inflammation
around
damaged
tissue.
Therefore,
MnO2@PDA,
high
biosafety,
hemostasis,
beneficial
capacity,
displays
exceptional
performance,
holding
great
potential
applications
Current Pharmaceutical Design,
Journal Year:
2024,
Volume and Issue:
30(21), P. 1650 - 1658
Published: May 7, 2024
Current
interest
in
adhesion
formation
stems
from
its
global
impact
on
the
function
and
quality
of
life,
spanning
a
spectrum
subtle
impairments
to
significant
disabilities,
based
affected
area
extent
adhesion.
Yet
therapeutic
agents
are
restricted
prophylactic
anti-inflammatories,
revision
surgeries,
biological
physical
techniques,
none
which
grant
decent
outcome.
Recent
advancements
tissue-
engineered
biomaterials,
drug
delivery
systems,
fabricating
technologies
such
as
nanoparticles,
hydrogels,
weaving
or
braiding
demonstrate
potential
for
improved
outcomes.
However,
mentioned
methods
have
reliable
outcomes,
thus
this
study
aims
elucidate
mechanisms
involved
pathophysiology
tendon
post-surgical
band
(PSAB),
with
closer
look
at
inflammatory
pathways
stimulating
process.
This
article
consolidates
information
diverse
cutting-edge
technologies,
aiming
provide
comprehensive
update
topic,
providing
researchers
an
avenue
new
innovative
ideas
further
investigations.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 2615 - 2615
Published: Sept. 15, 2024
The
aim
of
this
study
was
to
develop
a
material
capable
rapidly
absorbing
bodily
fluids
and
forming
resilient,
adhesive,
viscoelastic
hydrogel
in
situ
prevent
post-surgical
adhesions.
This
formulated
using
O-carboxymethyl
chitosan
(O-CMCS),
oxidized
hyaluronic
acid
(OHA),
crosslinking
pigment
derived
from
genipin
glutamic
(G/GluP).
Both
crosslinked
(O-CMCS/OHA-G/GluP)
non-crosslinked
hydrogels
(O-CMCS/OHA)
were
evaluated
HAAKE™
MARS™
rheometer
for
their
potential
as
barriers.
A
rheological
analysis,
including
dynamic
oscillatory
measurements,
revealed
that
the
exhibited
significantly
higher
elastic
moduli
(G′),
indicating
superior
gel
formation
mechanical
stability
compared
hydrogels.
G/GluP
crosslinker
enhanced
by
increasing
separation
between
G′
G″
achieving
lower
loss
tangent
(tan
δ
<
1.0),
robustness
under
physiological
conditions.
rapid
hydration
gelation
properties
underscore
effectiveness
physical
Furthermore,
O-CMCS/OHA-G/GluP
demonstrated
self-healing
efficient
application
via
spraying
or
spreading,
with
tissue
adherence
viscoelasticity
facilitate
movement
tissues
organs,
effectively
preventing
Additionally,
proved
be
both
cost
effective
scalable,
highlighting
its
clinical
applications
aimed
at
Fostering
cell
attachment
is
essential
for
tissue
engineering.
However,
unwanted
cellular
interactions
increase
the
risk
of
post-operative
adhesions
which
can
hinder
regeneration.
Thus,
cell-adhesion-promoting
and
cell-adhesion-inhibitory
functions
need
to
be
regulated
simultaneously.
We
develop
a
stably
joined
bilayer
film
composed
thin
polylactic
acid
(cell
interactive
side)
obtained
by
solvent
casting
coated
with
hyaluronic
antifouling
crosslinked
divinyl
sulphone,
seeking
reduce
after
surgery.
Both
layers
were
bonded
together
biocompatible
nitrocellulose-base
adhesive
forming
long-term
stable
due
reaction
between
their
chemical
groups
formation
semi-interpenetrating
polymeric
network
on
amorphous
regions
film.
A
thorough
physicochemical
characterisation
(morphology,
composition,
swelling
ratio
stability)
this
novel
type
scaffold
was
carried
out
ensure
comprehensive
understanding
its
structural
properties
performance
characteristics.
Schwann
culture
proved
surface
cell-friendly
promoting
proliferation
whereas
prevented
initial
adhesion.
