BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 20, 2025
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 1820 - 1845
Published: Jan. 9, 2024
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, BBB also prevents passage of various forms therapeutic agents, nanocarriers, their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe effective vehicles in neurotheranostics. In this Review, first we introduce anatomical physiological functions BBB. Second, present endogenous exogenous transport mechanisms by NPs cross We report nanomaterials, carriers, cargos, with detailed uptake permeability characteristics. Third, describe effect regulating size, shape, charge, surface ligands affect permeability, can be exploited enhance promote classify typical functionalized nanomaterials developed for crossing. Fourth, provide comprehensive review recent progress functional polymeric applications multimodal bioimaging, therapeutics, drug delivery. Finally, conclude discussing existing directions, future perspectives employing
Language: Английский
Citations
89
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 9 - 9
Published: March 23, 2025
Antibiotic resistance poses a significant global health challenge, undermining the effectiveness of conventional treatments and increasing mortality rates worldwide. Factors such as overuse misuse antibiotics in healthcare agriculture, along with poor infection control practices, have accelerated emergence resistant bacterial strains. The stagnation development new antibiotics, compounded by economic biological challenges, has necessitated alternative approaches to combat infections. Nanotechnology provides promising solution using nanoparticles (NPs), which bacteria through mechanisms like membrane disruption reactive oxygen species (ROS) generation. Metal-based silver zinc oxide possess intrinsic antimicrobial properties, while polymer- carbon-based enhance drug delivery biofilm penetration. Unlike operate multi-mechanistic pathways, reducing likelihood improving treatment efficacy. This review aims provide an updated, in-depth look at recent advances nanoparticle research targeting antibiotic resistance, discussing different types nanoparticles, action, current challenges opportunities. By exploring evolving role nanotechnology addressing this crisis, intends highlight potential for transform landscape infections inspire further into these innovative solutions.
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 653, P. 123889 - 123889
Published: Feb. 10, 2024
Language: Английский
Citations
16
Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 727 - 727
Published: June 29, 2024
With its unique properties and potential applications, nanoparticle-based delivery platforms for messenger RNA (mRNA) vaccines have gained significant attention in recent years. Nanoparticles the advantages of enhancing immunogenicity, targeting delivery, improving stability, providing a new solution drug vaccine delivery. In some clinical studies, variety nanoparticle been gradually applied to wide range applications. Current research priorities are exploring various types nanoparticles as systems enhance stability immunogenicity. Lipid (LNPs) shown promising preclinical studies on efficient antigens immune cells. Moreover, lipid other nucleic acids, especially mRNA systems, vast development. this review, we present with an emphasis vehicles. We describe several novel vaccines, such lipid-, polymer-, protein-based nanoparticles. addition, provide overview anti-tumor immunity nanovaccines against different tumors cancer immunotherapy. Finally, outline future perspectives remaining challenges technology vaccines.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2165 - 2165
Published: Feb. 10, 2024
The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, which nearly 350,000 melanoma, is often fatal. Treatment challenging and ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use nanoparticles may allow for early detection monitoring neoplastic changes determining effectiveness treatment. This article briefly reviews present understanding characteristics cancers, their epidemiology, risk factors. It also outlines possibilities using nanotechnology, especially nanoparticles, transport medicinal substances. Research over previous decade on carriers active substances indicates that drugs delivered more accurately tumor site, resulting higher therapeutic efficacy. describes application liposomes, carbon nanotubes, metal polymer existing therapies. discusses challenges encountered nanoparticle therapy improving performance. Undoubtedly, promising method help fight against cancer.
Language: Английский
Citations
13
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 315 - 315
Published: Feb. 28, 2024
Cancer continues to pose one of the most critical challenges in global healthcare. Despite wide array existing cancer drugs, primary obstacle remains selectively targeting and eliminating cells while minimizing damage healthy ones, thereby reducing treatment side effects. The revolutionary approach utilizing nanomaterials for delivering therapeutic agents has significantly enhanced efficacy safety chemotherapeutic drugs. This crucial shift is attributed unique properties nanomaterials, enabling nanocarriers transport tumor sites both passive active modes, drug elimination from delivery systems. Furthermore, these can be designed respond internal or external stimuli, thus facilitating controlled release. However, production nanomedications therapy encounters various that impede progress this field. review aims provide a comprehensive overview current state nanomedication treatment. It explores variety focusing on their are overcoming limitations conventional chemotherapy. Additionally, delves into functionalities nanocarriers, highlighting significant impact evolution nanomedicine. also critically assesses recent advancements systems, covering range innovative methodologies. Finally, succinctly addresses encountered developing nanomedications, offering insightful perspectives guide future research
Language: Английский
Citations
12
Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(37), P. 2922 - 2936
Published: Aug. 16, 2024
Solid Lipid Nanocarriers (SLNs) offer a promising avenue for breast cancer treatment, disease that accounts 12.5% of global cases. Despite strides in combined therapies (surgery, chemotherapy, radiation, and endocrine therapy), challenges like systemic toxicity, drug resistance, adverse effects persist. The manuscript offers several novel contributions to the field treatment through use SLNs, these are innovative delivery systems, multifunctionality, biocompatibility, potential overcome integration with emerging therapies, focus on personalized medicine, ongoing future research directions reduced side effects. SLNs present strategy due their unique physicochemical properties. They can encapsulate both hydrophilic hydrophobic drugs, ensuring controlled release targeted delivery, thus enhancing solubility bioavailability reducing multifunctional nature improves while biocompatibility supports therapy. Challenges pharmacists include maintaining stability, effective loading, timed delivery. Combining gene immunotherapy holds promise more treatments. represent significant advancement, providing precise fewer effects, overcoming resistance. Ongoing will refine therapy, targeting cells minimal integrating other treatments comprehensive approaches. Advances nanotechnology medicine tailor specific subtypes, effectiveness. Clinical trials new developments crucial realizing SLNs' full care. In conclusion, transformative approach addressing issues aims optimize potentially revolutionizing care hope patients.
Language: Английский
Citations
9
ChemMedChem, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Abstract Lipid nanoparticles (LNPs) have emerged as a transformative platform for the targeted delivery of therapeutic agents, revolutionizing treatment paradigms across spectrum diseases. Since inception liposomes in 1960s, lipid‐based nanotechnology has evolved to address limitations such poor bioavailability, off‐target effects, and instability, thereby enhancing efficacy safety drug administration. This review highlights latest advancements LNPs technology, focusing on their application cancer therapy, gene infectious disease management, glaucoma, other clinical areas. Recent studies underscore potential deliver messenger RNA (mRNA) small interfering (siRNA) precise genetic intervention, exemplified by breakthroughs interference CRISPR‐Cas9 genome editing. Additionally, been successfully employed ameliorate conditions, demonstrating versatility addressing both acute chronic disorders. However, challenges persist concerning large‐scale manufacturing, long‐term stability, comprehensive evaluations. Future research must focus optimizing formulations, exploring synergistic combinations with existing therapies, expanding scope treatable The integration into personalized medicine exploration applications diseases represent promising avenues further investigation. are poised play an increasingly central role development next‐generation therapeutics.
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125562 - 125562
Published: April 1, 2025
Cancer is a serious worldwide public health problem, ranking as the second leading cause of death in United States. The third most prevalent tumor kind world colon or rectal tumor. Colon (CC) common cancer and cancer-related deaths globally. In US, CC has become 2nd after having different advancements like detection, surgery, chemotherapy. current strategies for treating have several disadvantages, including higher toxicity, drug resistance, damage to healthy cells, solubility, specificity, lower therapeutic index, more. Solid lipid nanoparticles (SLNs) are viable targeted treatment option avoid this problem. This comprehensive review discussed severity, pathophysiology, risk factors, stages cancer. covers effective therapy diagnostic procedures, HSgFOBT, Fecal immunological test (FIT), Colonoscopy, FIT-DNA Test/mt-sDNA screening test, capsule (CCE), Blood-based DNA Tests, Flexible sigmoidoscopy. reviewemphasizes need novel specific approaches improve patient outcomes.
Language: Английский
Citations
1
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 162, P. 213903 - 213903
Published: May 24, 2024
Language: Английский
Citations
6