Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105950 - 105950
Published: Sept. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 180 - 180
Published: Feb. 1, 2025
Background/Objectives: Numerous diseases such as diabetes, Alzheimer’s disease, and cancer have spread in the whole world, especially Arab world. Also, various applications of Schiff-base functionalized nanoparticles copper oxide (CuO-NPs) therapeutic been discovered. Thus, current research highlights (i) synthesis produced with a Schiff base (SB) serving capping agent during their (ii) assessment vitro biological activities base-synthesized (SB-CuO-NPs) (SB). Methods: SB-CuO-NPs were characterized using ultraviolet-visible (UV-Vis) spectroscopy, zeta potential, DLS analysis, transmission electron microscope (TEM). It also focuses on assessing activities, including antioxidant, scavenging, anti-diabetic, anti-Alzheimer, anti-arthritic, anti-inflammatory, cytotoxic enzymes inhibitory methods described literature. Results: The results compared those SB. demonstrated superior when to SB from which they produced. Conclusions: this investigation concluded that CuO-NPs, synthesized an alternative agent, exhibited enhanced efficacy relative original In future, efficiency against Alzheimer’s, will be assessed experimental animals (in vivo).
Language: Английский
Citations
2
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100172 - 100172
Published: May 21, 2024
5-Fluorouracil (5FU) is a common chemotherapy drug for various cancers. It has exhibited large potentials the treatment of both malignant and premalignant tumors. In meantime, topical application 5FU been limited to surface pre-carcinogenic So far, number nano systems have developed encapsulation targeted delivery improve its solubility, bioavailability, functional characteristics, leading development of, example, carriers in treatments. Due their considerable advantages over ordinary therapies, nanotechnology-based (DDSs), particularly polymeric nanocarriers (PNCs), led some sorts evolution many fields, including disease diagnosis DDS. As naturally occurring polymer, chitosan (CS) long regarded because biodegradability, biocompatibility, polycationic nature, non-toxicity, non-allergenic nature. addition, pH-responsive nature CS provides an exact dispersion cancer environment, converting it promising carrier system. Utilization 5-FU into carbon indicated positive results such as tumors prevention activity. Researchers successfully synthesized handful with distinctive characteristics 5FU; these come different forms, nano-sized particles (NPs), composites (NCs), emulsions (NEs), fibers (NFs). This study reviews mechanism formulations by analyzing physicochemical corresponding DDS terms morphology, charge, release profile, driving force. A more detailed analysis was performed on most popular pharmaceutical applications 5FU-loaded NPs. Effective facilitation improvement therapeutic effects cancers were also indicated. Herein, readers are introduced nanoscale based natural polymers like platforms therapy. More recent discoveries mechanistic anticancer behavior NPs further discussed.
Language: Английский
Citations
10
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 296 - 296
Published: Feb. 24, 2025
Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.
Language: Английский
Citations
1
Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(15), P. 630 - 645
Published: May 13, 2024
Skin cancer is the most widespread type of malignant tumor representing a major public health concern. Considering numerous side effects associated with conventional treatments, phytotherapy may be regarded as viable medicinal alternative. This study aimed to investigate therapeutic potential Orbea variegata (L.) Haw, an ornamental plant, in treating skin using animal model induced by combination ultraviolet (UV) irradiation and sulfuric acid treatment. The hydroethanolic extract underwent phytochemical characterization, identifying presence reducing sugars, coumarins, alkaloids, flavonoids, tannins, saponins through qualitative screening. Quantitative analysis demonstrated significant amounts phenolic compounds (29.435 ± 0.571 mg GAE/g dry extract), flavonoids (6.711 0.272 QE/g tannins (274.037 11.3 CE/g extract). administration two concentrations (1 or 2 g/kg) male Swiss mice exhibited no marked adverse effects, evidenced serum aspartate aminotransferase (AST) alanine (ALT) enzyme activity levels. In addition, significantly reduced hyperplasia inflammation UV/sulfuric treatment noted tissue analyses decreased protein expression nuclear proliferation marker (Ki-67). improvement was decrease oxidative stress, indicated diminished lipid peroxidation levels, restoration endogenous antioxidant catalase (CAT) control Our findings considered for cancer, exhibiting its apparent safety efficacy carcinogenesis acid-induced mouse model, attributed content activities.
Language: Английский
Citations
7
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1851 - 1851
Published: Aug. 14, 2024
Advances in melanoma research have unveiled critical insights into its genetic and molecular landscape, leading to significant therapeutic innovations. This review explores the intricate interplay between alterations, such as mutations BRAF, NRAS, KIT, pathogenesis. The MAPK PI3K/Akt/mTOR signaling pathways are highlighted for their roles tumor growth resistance mechanisms. Additionally, this delves impact of epigenetic modifications, including DNA methylation histone changes, on progression. microenvironment, characterized by immune cells, stromal soluble factors, plays a pivotal role modulating behavior treatment responses. Emerging technologies like single-cell sequencing, CRISPR-Cas9, AI-driven diagnostics transforming research, offering precise personalized approaches treatment. Immunotherapy, particularly checkpoint inhibitors mRNA vaccines, has revolutionized therapy enhancing body’s response. Despite these advances, mechanisms remain challenge, underscoring need combined therapies ongoing achieve durable comprehensive overview aims highlight current state transformative impacts advancements clinical practice.
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 632 - 632
Published: May 8, 2024
A nanoparticle’s shape is a critical determinant of its biological interactions and therapeutic effectiveness. This study investigates the influence on performance mesoporous silica nanoparticles (MSNs) in anticancer therapy. MSNs with spherical, rod-like, hexagonal-plate-like shapes were synthesized, particle sizes around 240 nm, their other surface properties characterized. The drug loading capacities three controlled to be 47.46%, 49.41%, 46.65%, respectively. effects release behaviors, cellular uptake mechanisms, pharmacological behaviors systematically investigated. Through series vitro studies using 4T1 cells vivo evaluations tumor-bearing mice, kinetics, effects, circulation profiles, efficacy comprehensively assessed. Notably, hexagonal-plate-shaped loaded PTX exhibited prolonged time (t1/2 = 13.59 ± 0.96 h), which was approximately 1.3 times that spherical 10.16 0.38 h) 1.5 rod-shaped 8.76 1.37 h). research underscores significance nanoparticles’ dictating outcomes, providing valuable insights for rational design targeted delivery systems cancer
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142486 - 142486
Published: March 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 141 - 176
Published: Jan. 1, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1200 - 1200
Published: Sept. 12, 2024
Skin cancer is a high-incidence complex disease, representing significant challenge to public health, with conventional treatments often having limited efficacy and severe side effects. Nanocarrier-based systems provide controlled, targeted, efficacious methodology for the delivery of therapeutic molecules, leading enhanced efficacy, protection active molecules from degradation, reduced adverse These features are even more relevant in dual-loaded nanosystems, encapsulated drug synergistic antitumor This review examines potential improving treatment skin through liposomal systems. The performed analysis focused on characterization developed formulations' particle size, polydispersity index, zeta potential, encapsulation efficiency, release, vitro and/or vivo safety. combination agents such as doxorubicin, 5-fluorouracil, paclitaxel, cetuximab, celecoxib, curcumin, resveratrol, quercetin, bufalin, hispolon, ceramide, DNA, STAT3 siRNA, Bcl-xl Aurora-A inhibitor XY-4, 1-Methyl-tryptophan, cytosine-phosphate-guanosine anionic peptide led increased targeted anticancer effects, complementary effects well, including antioxidant, anti-inflammatory, immunomodulatory activities, all pathophysiology. substantial co-loaded highly promising advancing demonstrated.
Language: Английский
Citations
2
Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 627 - 627
Published: Sept. 29, 2024
Origanum vulgare ssp. hirtum essential oil (OEO) is a natural with high therapeutic potential. For some applications, however, the development of novel formulations still needed to improve bioavailability and stability OEO. In this study, we describe fabrication an original nanocomposite hydroxypropyl cellulose (HPC) physical hydrogel, containing OEO-loaded polymeric micelles, for topical delivery. The concentration main active compounds OEO—carvacol thymol—was determined using gas chromatography (GC) analysis. OEO was first encapsulated into Pluronic F127 then embedded HPC gel. Micellar gel pure polymers OEO-containing systems were characterized by dynamic light scattering (DLS) rheology measurements, respectively. Selected evaluated cytotoxicity antiproliferative activity. hydrogel formulation micellar (8% HPC, 2% F127, 1% OEO) exhibited sustained release selectivity towards SH-4 tumor cells (an in vitro model melanoma).
Language: Английский
Citations
2