BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 20, 2025
Language: Английский
Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16
Published: Jan. 28, 2025
The fabrication of furosemide (FSM) with enhanced oral bioavailability and encapsulation was achieved using a nanostructured lipid carriers (NLCs) drug delivery system.Significance: uniform distribution is barrier due to its low dose. lipid-based system selected based on poor solubility permeability, limiting partitioning in water-based polymeric systems. lipophilicity the FSM makes it favorable partition triglyceride Compritol 888 ATO oleic acid minimized expulsion, high payload, sustained release over extended time frames. Organic aqueous phase microemulsion were stabilized Tween 80, hydrophilic surfactant. Box-Behnken design-based optimization done alteration various formulation variables obtain nano-formulation lowest particle size polydispersity whereas, maximal zeta potential entrapment efficiency. Design-Expert yielded several optimized formulations desirability function. Maximum obtained at around 178 nm, surface charge -19.6 mV, an EE above 85%.The vitro profile depicted 86.5% cumulative after 24 h vivo pharmacokinetic study revealed increase Cmax from 0.48 µg/mL (FSM-Suspension) 0.77 (FSM NLCs) approx. 241% NLCs. half-life escalation demonstrated that residence nanoparticles prolonged physiologic pH. FSM-NLCs exhibited period, improved body their action prolonged.
Language: Английский
Citations
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Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15
Published: Jan. 29, 2025
Abemaciclib (ABE) is an anticancer drug that suffers from low bioavailability and multidrug resistance. This study aims to develop ABE-loaded solid lipid nanoparticles (ABE-SLNs), which will enhance solubility lead increased cellular uptake enhanced cytotoxicity when delivering tumor cells. Melt emulsification followed by ultrasonication was used as a method of preparation Quality-by-Design (QbD) utilized optimize ABE-SLNs. The optimized ABE-SLNs consist Precirol-ATO5 Brij-58 surfactant. particle size, PDI value, zeta potential the formulation were 170.4 ± 0.49 nm, 0.25 0.014, -26.4 0.1 mV, respectively. It also showed sustained release behavior high entrapment efficiency 79.96%. exhibited activity in MDA-MB-231 T47D breast cancer cell lines compared pure ABE. In Caco-2 human colonic lines, uptake. use QbD achieve ABE-SLNs, coupled with cytotoxicity, represents novel approach could set new standard for nanoparticle-based delivery systems.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 641 - 641
Published: Jan. 31, 2025
Naturally available antioxidants offer remarkable medicinal applications in wound healing. However, the encapsulation of these phytoactive moieties into suitable nano-scale drug delivery systems has always been challenging due to their inherent characteristics, such as low molecular weight, poor aqueous solubility, and inadequate skin permeability. Here, we provide a systematic review focusing on major obstacles hindering development various lipid polymer-based transporters carry cargos targeted site. Additionally, this covers possibility combining effects polymer within one system, which could increase permeability threshold. Moreover, lack physical characterization techniques challenges associated with scaling up progression nano-carriers limit utility biomedical applications. In context, consistent progressive approaches for addressing shortcomings are introduced, prospects discussed detail.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 20, 2025
Language: Английский
Citations
0