From nature to nanomedicine: bioengineered metallic nanoparticles bridge the gap for medical applications

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 9, 2024

Abstract The escalating global challenge of antimicrobial resistance demands innovative approaches. This review delves into the current status and future prospects bioengineered metallic nanoparticles derived from natural sources as potent agents. unique attributes abundance resources have sparked a burgeoning field research in combating microbial infections. A systematic literature was conducted, encompassing wide range studies investigating synthesis, characterization, mechanisms nanoparticles. Databases such PubMed, Scopus, Web Science, ScienceDirect, Springer, Taylor & Francis online OpenAthen were extensively searched to compile comprehensive overview topic. synthesis methods, including green sustainable approaches, examined, diverse biological used nanoparticle fabrication. amalgamation products has yielded promising Their multifaceted mechanisms, membrane disruption, oxidative stress induction, enzyme inhibition, render them effective against various pathogens, drug-resistant strains. Moreover, potential for targeted drug delivery systems using these opened new avenues personalized medicine. Bioengineered represent dynamic frontier battle underscores their remarkable efficacy action. Future are bright, with opportunities scalability cost-effectiveness through methods. However, addressing toxicity, regulatory hurdles, environmental considerations remains crucial. In conclusion, this highlights evolving landscape nanoparticles, offering valuable insights revolutionize therapy future. Graphical

Language: Английский

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Tailoring of an anti-diabetic drug empagliflozin onto zinc oxide nanoparticles: characterization and in vitro evaluation of anti-hyperglycemic potential

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 30, 2024

Diabetes is a serious health issue that can be great risk factor related to numerous physical problems. A class of drugs "Gliflozin" especially Sodium Glucose Co. Transporter 2 was inhibited by novel drug, which known as "empagliflozin". While ZnO nanoparticles (NPs) had considerable promise for combating diabetes, it employed in the treatment and management type-2 diabetes mellitus. The new drug empagliflozin initially incorporated into Zinc Oxide NPs this study using surface physio-sorption technique, degree adsorption assessed HPLC method. tailored product characterized FTIR, EDX, Ultraviolet-Visible, XRD SEM techniques. With an average particle size 17 nm, revealed mono-dispersion sphere-like form. Freundlich isotherm model best fits explains data investigation, examined capabilities isotherms. enzymes α-amylase α-glucosidase, are involved human metabolism carbohydrates, were used in-vitro anti-diabetic assays. It discovered composite showed highest levels 81.72 92.77% inhibition -α-amylase -glucosidase at absolute concentration 1000 μg per ml with IC50 values 30.6 72 ml.

Language: Английский

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Optimization and characterization of quercetin-loaded solid lipid nanoparticles for biomedical application in colorectal cancer

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 26, 2024

Abstract Background Colorectal cancer (CRC) is a type of that affects the colon or rectum and occurs in individuals over age 50, although it can affect people all ages. Quercetin flavonoid, which plant pigment with antioxidant anti-inflammatory properties. Some studies have explored potential quercetin as an adjuvant therapy to enhance effectiveness chemotherapy radiation therapy. Methodology In proposed work, nano-biomaterials solid lipids such stearic acid (SA) tripalmitin (TpN) well surfactants tween 80 span were used prepare novel (QuR)-loaded-solid lipid nanoparticles (QuR-SLNs) for medical applications colorectal (CRC). The resulting bio-nano SLNs’ mean entrapment efficiency (EE) particle size (PS) optimized by Box–Behnken design (BBD) approach based on response-like surface methodology (RSM). variables include ratio ( X 1 ), surfactant 2 QuR-to-lipid 3 sonication time 4 homogenization 5 ). Requirements maximum EE (%) minimum PS (nm) preparation QuR-SLN. Differential scanning calorimetry (DSC), X-ray diffraction (XRD) analysis, electron microscopy (SEM) then analyze SLN find crystalline state QuR relationship. addition, Caco-2 cells, at IC 50 (49 µM/mL), vitro cytotoxicity was attained. Results QuR-SLN had practically spherical shapes, % 97.8 ± 1.16% 132.16 4.1 nm, respectively. aqueous media, degree crystallinity modification investigated, incorporation release patterns showed high correlations both. results 41.12 1.6% QuR-SLNs released gradually course 48 h, demonstrating effective delayed release. apoptotic observations indicate apoptosis accounts majority cell death, while necrosis, constitutes very minor portion. conclusion, prepared might improve act ideal carrier delivery this treatment CRC.

Language: Английский

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Hansen Solubility Parameters, Computational, and Thermodynamic Models for Tofacitinib Citrate Solubility in Neat Mono Solvents, and GastroPlus Based Predicted In Vivo Performance of Subcutaneous Solution in Humans

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)

Published: Feb. 18, 2025

Language: Английский

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Enhanced rivastigmine delivery through nanoemulsion and pyridoxine supplementation: An in-vivo study on Alzheimer's disease intervention

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2025, Volume and Issue: 65, P. 102810 - 102810

Published: Feb. 28, 2025

Language: Английский

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Development, Statistical Optimization, and Characterization of Resveratrol‐Containing Solid Lipid Nanoparticles (SLNs) and Determination of the Efficacy in Reducing Neurodegenerative Symptoms Related to Alzheimer’s Disease: In Vitro and In Vivo Study

BioMed Research International, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Resveratrol (RSV), as a natural polyphenol exhibiting antioxidative properties, is studied in the treatment of neurodegenerative diseases. However, RSV has low oral bioavailability. In this study and order to overcome issue, was encapsulated into solid lipid nanoparticles (SLNs). study, RSV‐loaded (RSV‐SLNs) were prepared by solvent emulsification‐evaporation technique, their physicochemical properties optimized using Box–Behnken response surface methodology. The morphology particles evaluated scanning electron microscopy (SEM) transmission (TEM). neuroprotective effects investigated animal models Morris water maze (MWM). Then after, rats sacrificed, brains collected, extent peroxidase (LPO) well level reduced glutathione (GSH) determined hippocampus section samples. Finally, collected brain tissues histologically studied. particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE%), drug loading (DL%) 104.5 ± 12.3 nm, 0.322 0.11, −3.1 0.15 mV, 72.9 5.31 % 14.6 0.53 , respectively. microscopic images revealed spherically shaped nonaggregated nanoparticles. vivo studies demonstrated higher RSV‐SLN reduction escape latency time improvement spent target quadrant compared free RSV. Moreover, it that posed potency LPO elevation GSH levels histological decline neural degeneration an CA1 pyramidal cell morphology. obtained data RSV‐SLNs caused more Alzheimer‐related symptoms rather than

Language: Английский

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Advances in Nanomaterials for Drug Delivery

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2023, Volume and Issue: unknown, P. 22 - 85

Published: Nov. 3, 2023

This chapter provides a comprehensive review of recent advances in nanomaterials for drug delivery, focusing on the design and preparation nanocarriers. It also dissects intricate mechanisms underpinning loading release, delves into strategic planning inherent achieving target delivery. further outlines potential applications these treating various diseases, including cancer, infectious neurological disorders. A distinct case study is incorporated chapter, elucidating promising utility electrospun nanofibers delivery paradigms. In its concluding remarks, engages thoughtful discourse about persistent challenges within this rapidly evolving field. forecasts trajectories future exploration innovation captivating domain

Language: Английский

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Tofacitinib in Dermatology: A Potential Opportunity For Topical Applicability Through Novel Drug-Delivery Systems

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(1), P. 79 - 101

Published: Jan. 1, 2024

Tofacitinib is a first-generation JAK inhibitor approved by the US FDA for treating rheumatoid arthritis. It exhibits broad-spectrum inhibitory effect with abilities to block JAK-STAT signalling. The primary objective of this review obtain knowledge about cutting-edge methods effectively variety skin problems including tofacitinib into formulations that are based on nanocarriers. also highlights clinical trials and offers an update published patents. Nanocarriers provide superior performance compared conventional treatments in terms efficacy, stability, drug bioavailability, target selectivity sustained release. Current has potential make significant contributions ongoing discussion involving dermatological prospective impact nanotechnology transforming healthcare within field.

Language: Английский

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Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 25, 2024

Abstract Poly l (+) lactic acid (PLLA) has become crucial in the biomedical industry for various uses. The direct polycondensation method was used to prepare Lactic Acid (PLLA). Different catalysts, including metal oxides and halides, were test polymerization technique. effect of amount catalysts type coupling agent investigated. reaction time solvents also studied. PLLA loaded with isosorbide dinitrate utilizing solvent evaporation process. synthesized polymer-drug system evaluated by different means such as FT-IR, TGA, DSC, XRD, entrapment efficiency (E.E), drug loading (D.L), particle size analysis, zeta potential determination. Studies on in-vitro release using UV light at 227 nm pH levels conducted, kinetics cytotoxicity sulforhodamine B (SRB) assay human skin fibroblast cells examined.

Language: Английский

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Contemplating Novel W/O Emulsion Based Gel for Anti-Psoriatic Activity of Tofacitinib in Imiquimod-Induced Balb/C Mice Model

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 26(1)

Published: Dec. 13, 2024

Language: Английский

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