Surface Modified Glucose‐Derived, Blood–Brain Barrier‐Crossing Nanospheres Dually Targets Macrophage and Cancer Cells for Effective In Situ Anti‐Glioma Effect DOI
Madhan Mohan Chandra Sekhar Jaggarapu, Aasia Ansari, Sudhakar Jinka

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract Glucose‐derived carbon nanospheres (CSP), uniquely derived by hydrothermal condensation process, inherently cross blood–brain‐barrier (BBB) but distribute all over the brain. Albeit its potential to treat glioma as an effective drug delivery system, it is challenging restrict drug‐associated CSP within region and reduce non‐specific side effects. Incidentally, gliomas moderately express sigma receptors (SR). Earlier, a cationic lipid‐conjugated neuropsychotic drug, haloperidol (H8) developed with SR‐targetability anticancer effect zero BBB‐crossing ability. In this study, surface modified H8 (CH8 nano‐conjugate) dual targeting achieved glioma‐tumor microenvironment: 1) cells 2) pro‐proliferative M2 tumor‐associated macrophages (TAM), both SR. CH8‐treatment increases survivability of orthotopic bearing mice significantly reduces tumor burden in glioma‐subcutaneous model. Further CH8‐surface combining brain carmustine (CH8‐CRM). CH8‐CRM nano‐conjugate selectively enhances glioma‐carrying aggressiveness comparison other treatment groups. Lysates from CH8‐CRM‐treated show upregulation cleaved‐caspase 3, p53, downregulation pAkt. The combination pronouncedly anti‐glioma H8. Conclusively, CH8‐mediated dual‐targeting via SR glioma‐associated exemplifies repurposing drugs for treating glioma.

Language: Английский

Enhancing biocompatibility and functionality: Carbon nanotube-polymer nanocomposites for improved biomedical applications DOI

M. Maghimaa,

Suresh Sagadevan,

E Boojhana

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105958 - 105958

Published: July 9, 2024

Language: Английский

Citations

20

Mechanism of polymer composite-based nanomaterial for biomedical applications DOI Creative Commons

Nadeem Hussain Solangi,

Rama Rao Karri, Nabisab Mujawar Mubarak

et al.

Advanced Industrial and Engineering Polymer Research, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Recent developments in nanomaterials have come to extensive use various fields, especially the biomedical industry. Numerous significant obstacles still need be overcome, particularly those about utilizing science, before they can used for medicinal purposes. Major issues biomedicine include biological functioning, harmony, toxic effects, and nano-bio surface properties. Thus, researchers may cutting-edge characterization approaches study applications. Two-dimensional polymers are crucial components of systems. Polymer-based flexible more resistant chemical attack than other NPs. Polymers easily form composite or functionalization with NPs improve their performance compared traditional The current review article discussed nanomaterial performance, including carbon nanotubes (CNTs), graphene, MXene polymers-based state area is illustrated this summary article, along applications significance approaches. advanced methods examining interior geometry, structure, morphology piece writing, Transmission electron microscopy (TEM), Scanning electronic (SEM), Atomic Force Microscopy (AFM), Magnetic resonance force (MRFM) X-ray diffraction (XRD). Finally, authors associated

Language: Английский

Citations

41

Nanotechnology development in surgical applications: recent trends and developments DOI Creative Commons
Farzad Abaszadeh, Muhammad Hossein Ashoub,

Ghazal Khajouie

et al.

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Nov. 24, 2023

Abstract This paper gives a detailed analysis of nanotechnology's rising involvement in numerous surgical fields. We investigate the use nanotechnology orthopedic surgery, neurosurgery, plastic oncology, heart vascular ophthalmic thoracic and minimally invasive surgery. The details how helps with arthroplasty, chondrogenesis, tissue regeneration, wound healing, more. It also discusses employment nanomaterials implant surfaces, bone grafting, breast implants, among other things. article explores various uses, including stem cell-incorporated nano scaffolds, nano-surgery, hemostasis, nerve nanorobots, diagnostic applications. ethical safety implications using surgery are addressed. future possibilities investigated, pointing to possible route for improved patient outcomes. essay finishes comment on transformational influence applications its promise breakthroughs. Graphical

Language: Английский

Citations

38

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders DOI
Biswajeet Acharya, Amulyaratna Behera,

Suchismeeta Behera

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 1336 - 1361

Published: Feb. 27, 2024

Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important reproductive health care, which become an emerging significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, cancers. Nanotechnology presents promising solutions to address these by introducing innovative tools techniques, facilitating early detection, targeted improved imaging capabilities. Through utilization nanoscale materials devices, researchers can craft treatments that are not only more precise but also effective, significantly enhancing outcomes healthcare. Looking forward, future medicine holds immense potential for reshaping diagnostics, personalized therapies, fertility preservation. The nanotechnology-driven delivery systems anticipated elevate treatment effectiveness, minimize side effects, offer patients therapies efficient. review aims delve various types, properties, preparation techniques nanocarriers specifically designed context disorders, shedding light on current landscape directions this dynamic field.

Language: Английский

Citations

17

Single‐Walled Carbon Nanotube‐Based Optical Nano/Biosensors for Biomedical Applications: Role in Bioimaging, Disease Diagnosis, and Biomarkers Detection DOI

Rumi Acharya,

Tejal V. Patil, Sayan Deb Dutta

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: 9(20)

Published: May 16, 2024

Abstract The convergence of advanced nanotechnology with disease diagnosis has ushered in a transformative era healthcare, empowering early and accurate detection diseases paving the way for timely interventions, improved treatment outcomes, enhanced patient well‐being. development novel materials is frequently impetus behind significant advancements sensor technology. Among them, single‐walled carbon nanotubes (SWCNTSs) have emerged as promising nanomaterials developing biosensors. Their unique optical, electrical, biocompatibility properties make them candidates enhancing sensitivity real‐time monitoring capabilities biosensors, well enabling various bioimaging techniques. Recent studies demonstrated utility SWCNTS‐based biosensors biological analytes, such nitric oxide hydrogen peroxide (H 2 O ), potential implications understanding therapeutic response assessment. Moreover, SWCNTSs shown promise applications, including fluorescence, Raman spectroscopy, photoluminescence imaging samples. This article delves into core principles, design strategies, operational mechanisms that underpin SWCNTS‐bioimaging techniques‐based It emphasizes on their versatile functionalization nanotubes, laying foundation integration biosensor platforms applications aimed at diagnosing wide spectrum infectious diseases, cancer, neurological disorders, metabolic conditions.

Language: Английский

Citations

13

Nano-Enhanced Polymer Composite Materials: A Review of Current Advancements and Challenges DOI Open Access
Abdulrahman Adeiza Musa, Abdulhakeem Bello,

Sani Mohammed Adams

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 893 - 893

Published: March 26, 2025

Nanomaterials have demonstrated significant potential in enhancing the performance and functionality of composite materials across various industrial applications. This review delves into unique properties nanomaterials, with a particular focus on carbon-based presents key findings their effectiveness improving performance. The study emphasizes specific nano-based materials, highlighting substantial promise advancing field nanocomposites. Additionally, it addresses challenges associated production utilization nanocomposite discusses solutions to overcome these obstacles. concludes recommendations for further research innovation nanocomposites fully harness advantages advanced broader future

Language: Английский

Citations

2

A Narrative Review of In‐Textile Sensors in Human Health Applications DOI

Aaron Asael Smith,

Rui Li, Lulu Xu

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: 9(16)

Published: May 25, 2024

Abstract Sensors have become more versatile and sophisticated in recent years to fulfill the increasing demands for human health applications. Physiological information such as electrocardiogram, pulse rate, respiration are essential indications of personal health, often collected vitals, which typically from medical‐grade electrocardiogram (ECG) machines. In‐textile sensors a fast‐growing sub‐category wearable embedded smart textiles acquire physiological movement index provide harmful chemical warnings without compromising comfortable nature clothing. Recent literature has shown that integrating new materials greatly improved stability, specificity, selectivity in‐textile sensors. For example, polyvinylidene fluoride nanofiber produced highly stretchable sensor measure ECG readings during losing data quality. This review discusses group nanomaterial‐based consumer use home, workplace, healthcare environments. will focus on exploring analyzing latest developments these e‐textiles due their ability be easily integrated daily great potential medical Future work necessary incorporate recycled materials, improve method powering sensors, ultimately refine designs appropriate sustainable use.

Language: Английский

Citations

4

Comprehensive evaluation of MWCNT/HAp and Cu-functionalized MWCNT/HAp coatings on Ti6Al4V implants: Enhancing surface characteristics and biocompatibility via plasma electrolytic oxidation DOI Creative Commons

M. Logesh,

Sang‐Gun Ahn, Han‐Cheol Choe

et al.

Journal of Materials Research and Technology, Journal Year: 2024, Volume and Issue: 33, P. 7620 - 7644

Published: Nov. 1, 2024

Language: Английский

Citations

4

Electric field inducing quick release and targeted migration of corrosion inhibitors loaded by CTAB-MMT/epoxy coatings for enhancing self-healing properties DOI

Anqi Gong,

Zhengqing Yang, Lida Wang

et al.

Corrosion Science, Journal Year: 2024, Volume and Issue: 234, P. 112120 - 112120

Published: May 17, 2024

Language: Английский

Citations

3

Magnetite-Incorporated 1D Carbon Nanostructure Hybrids for Electromagnetic Interference Shielding DOI Creative Commons
Bayan Kaidar, Aigerim Imash, Gaukhar Smagulova

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(15), P. 1291 - 1291

Published: July 31, 2024

The increasing reliance on electronic technologies has elevated the urgency of effective electromagnetic interference (EMI) shielding materials. This review explores development and potential magnetite-incorporated one-dimensional (1D) carbon nanostructure hybrids, focusing their unique properties synthesis methods. By combining magnetite’s magnetic with electrical conductivity mechanical strength nanostructures such as nanotubes (CNTs) fibers (CFs), these hybrids offer superior EMI performance. Various techniques, including solvothermal synthesis, in situ growth, electrostatic self-assembly, are discussed detail, highlighting impact structure resulting composites. also addresses challenges achieving homogeneous dispersion nanofillers environmental economic considerations large-scale production. hybrid materials’ multifunctionality, enhanced strength, thermal stability, resistance, underscores suitability for advanced applications aerospace, electronics, protection. Future research directions focus optimizing processes exploring new configurations to further improve practical applicability.

Language: Английский

Citations

3