Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

In Vitro Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes DOI Creative Commons

Islam Alfreahat,

Hamdi Nsairat, Ibrahim Al‐Deeb

et al.

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. This study aimed to evaluate the potentiation of against MCF-7 cancer cell line encapsulating both CAM in PEGylated liposomes. liposomes containing were prepared using thin film hydration method. The physicochemical properties liposomes, average particle size, polydispersity index (PDI), zeta potential, characterized. Encapsulation efficiencies assessed, stability was evaluated over 9 days at room temperature. Cell viability measured an IC50 assay, P-gp expression levels determined ELISA. CAM/DOX-PEGylated exhibited optimal size (238 ± 26.7 nm), PDI (0.29 0.107), potential (-20.9 2.17 mV). These maintained good regarding charge days. 81.05% 78.13% DOX. value 0.13 µM, representing significant reduction compared physical mixture (0.25 µM) free (0.21 cells. ELISA analysis showed approximately 5% with 1.61% results indicate that encapsulated enhances cells, likely inhibition p-glycoprotein. approach may offer promising strategy overcome improve chemotherapy outcomes.

Language: Английский

Citations

2
Preparation, Optimization and In vitro Evaluation of Doxorubicin‐loaded into Hyaluronic Acid Coated Niosomes Against Breast Cancer DOI

Haya Faddah,

Hamdi Nsairat, Naeem Shalan

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(2)

Published: Jan. 1, 2024

Doxorubicin (DOX) is widely used against solid tumors. Niosomes are self-assembled nanocarriers of non-ionic surfactants. DOX loaded into cationic niosomes (DOX-Nio) was prepared via thin film hydration method. DOX-Nio then decorated with a hyaluronic acid (DOX-HA-Nio) electrostatic interaction. and DOX-HA-Nio displayed particle size 120.0±1.02 182.9±2.3 nm, charge + 35.5±0.15 -15.6±0.25 mV, respectively, PDI < 0.3. showed good stability regarding over 4 weeks at °C maintain their integrity after lyophilization. HPLC results 94.1±4.2 % encapsulation efficiency entrapment slow, prolonged release even 48 hrs. Cell viability assay an IC

Language: Английский

Citations

10
Advancements of metallic nanoparticles: A promising frontier in cancer treatment DOI Creative Commons
Ali Al‐Samydai, Maha N. Abu Hajleh,

Farah Al-Sahlawi

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.

Language: Английский

Citations

8
Evaluation of Preclinical Efficacy of Curcumin-Loaded Bicosome Systems in Amelioration of Oral Mucositis DOI Creative Commons
Daniela Vergara, Claudia Sanhueza,

Susana Méndez

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 181 - 181

Published: Feb. 1, 2025

Background/Objectives: Oral mucositis (OM) is a common and debilitating side effect of cancer therapy, characterized by ulceration or inflammation the oral mucosa. This study evaluates preclinical efficacy curcumin-loaded bicosome systems (cur-BS) in mitigating chemotherapy-induced OM mice. Methods: BS were prepared using combination 1,2-di-palmitoyl-sn-glycero-3-phosphocholine (DPPC) 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC), α-tocopherol, curcumin, encapsulated within liposomal vesicles. Three formulations with different curcumin concentrations (180, 540, 900 μM) particle size, polydispersity index (PDI), encapsulation efficiency (EE), appearance, morphology. The formulation highest concentration (cur-BS 5×) was selected for ex vivo permeability studies, release profile analysis, vitro anti-inflammatory efficacy. induced mice 5-fluorouracil (5-FU) acetic acid. Cur-BS 5× compared to commercial product Dentoxol®. Results: results showed that cur-BS provided sustained through mechanism involving both diffusion matrix relaxation, enhancing retention deeper skin layers. Treatment downregulated expression inflammatory markers (IL-1β TNF-α). Macroscopic assessments demonstrated Dentoxol® reduced severity, greatest improvement observed between days 6 9. By day 24, scores 1.25 ± 0.5 1.0 0.0 Dentoxol®, indicating effectiveness treatments. However, histological analysis revealed superior tissue recovery 5×, showing better epithelial structure inflammation. 5×-treated also exhibited greater weight higher survival rates group. Conclusions: These findings suggest may enhance treatment, offering outcomes comparable than those

Language: Английский

Citations

0
Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy DOI
Ali Al‐Samydai, Hamdi Nsairat, Maha N. Abu Hajleh

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: April 26, 2024

Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) IC

Language: Английский

Citations

3
Hyaluronic Acid in Nanopharmaceuticals: An Overview DOI Creative Commons
Sina M. Matalqah, Zainab Lafi,

Sara Yousef Asha

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 10444 - 10461

Published: Sept. 20, 2024

Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays critical role in maintaining skin structure and hydration. Its unique properties make it valuable component the field of nanopharmaceuticals. The combination HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving delivery efficacy drugs. HA-based nanoparticles, including solid lipid polymeric nanogels, offer controlled release, enhanced stability, targeted agents. These innovations significantly improve outcomes reduce side effects, making an essential tool modern medicine. In general, HA-modified liposomes enhance drug encapsulation targeting, while nanoparticles (SLNs) provide core for encapsulation, offering release stability. This article provides overview potential applications recent advancements nanopharmaceuticals, emphasizing significant impact on evolving advanced strategies. By delving compatibility this review underscores promising revolutionizing

Language: Английский

Citations

3
Innovative snail-mucus-extract (SME)-coated nanoparticles exhibit anti-inflammatory and anti-proliferative effects for potential skin cancer prevention and treatment DOI Creative Commons

Consoli Valeria,

Salvatore Petralia,

Vanella Luca

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(11), P. 7655 - 7663

Published: Jan. 1, 2024

Nowadays, several studies have highlighted the ability of snail mucus in maintaining healthy skin conditions due to its emollient, regenerative and protective properties.

Language: Английский

Citations

2
Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

Citations

1