Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Liposomes
are
employed
for
the
delivery
of
molecular
cargo
in
several
classes
systems.
For
instance,
embedding
loaded
liposomes
polymeric
fibrous
scaffolds
has
enabled
creation
hybrid
materials
that
mimic
biological
membranes.
with
unmodified
surfaces
have
been
predominantly
integrated
into
fibers,
which
leads
to
instabilities
due
interfacial
incompatibility.
In
addition,
electrospinning
almost
exclusively
fiber
fabrication,
limits
potential
scale-up
production.
Here,
we
present
fabrication
biomimetic
by
fusing
polymer-coated
force-spun
microfibers
increase
stability
and
enhance
sustained
release
cargo.
l-α-Phosphatidylcholine
were
coated
chitosan
or
polyethylene
glycol
(PEG).
The
nano-differential
scanning
calorimetry
results
confirm
polymer
coating
does
not
affect
phase
transition
temperature
(T
m)
liposomes,
where
only
model
drug,
quercetin,
reduced
T
m.
Centrifugal
spinning
was
fabricate
hydrophobic
polycaprolactone
(PCL)
at
various
concentrations
using
solvents
parameters
yield
lowest
diameter.
highest
microfiber
production
rate
obtained
occurred
a
20%
(w/v)
PCL
concentration
50
:
(v/v)
chloroform
methanol
solution
an
average
diameter
584.85
±
26.30
nm.
non-chemical
fusion
promoted
immersion
>
m,
under
ultrasonication.
We
hypothesize
is
driven
interactions
between
merge
through
lipid
bilayer.
fused
material
solved
burst
problem
observed
when
adhering
plain
nanofibers.
Both
PEG
yielded
release,
former
faster.
These
demonstrate
enables
more
effective
blending
carriers
microfibers.
Ultimately,
liposome/microfiber
hybrids
stable
matrices
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
8, P. 100265 - 100265
Published: June 26, 2024
Cancer
remains
a
major
global
health
challenge,
and
despite
available
treatments,
its
prognosis
poor.
Recently,
researchers
have
turned
their
attention
to
intelligent
nanofibers
for
cancer
drug
delivery.
These
exhibit
remarkable
capabilities
in
targeted
controlled
release.
Their
inherent
characteristics,
such
as
high
surface
area-to-volume
ratio,
make
them
attractive
candidates
delivery
applications.
Smart
can
release
drugs
response
specific
stimuli,
including
pH,
temperature,
magnetic
fields,
light.
This
unique
feature
not
only
reduces
side
effects
but
also
enhances
the
overall
efficiency
of
systems.
Electrospinning,
widely
used
method,
allows
precision
fabrication
smart
nanofibers.
Its
advantages
include
efficiency,
user-friendliness,
ability
control
various
manufacturing
parameters.
In
this
review,
we
explore
latest
developments
producing
electrospun
treatment.
Additionally,
discuss
materials
these
critical
parameters
involved
electrospinning
process.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(27), P. 29840 - 29847
Published: June 27, 2024
Nanofibers
made
of
different
materials
have
been
continuously
studied
and
widely
used
as
membranes
due
to
their
simple
fabrication
techniques
tunable
surface
characteristics.
In
this
work,
we
developed
polyacrylonitrile
(PAN)
nanofiber
by
the
electrospinning
method
blended
them
with
polysulfone
(PSU)
obtain
superhydrophobic
surfaces
on
fiber
structures.
The
scanning
electron
microscopy
(SEM)
images
show
that
fabricated
nanofibers
smooth
continuous
morphology.
addition,
observe
effect
PSU-based
blending
material,
Fourier-transform
infrared
(FTIR)
spectra
samples
were
acquired,
providing
chemical
compositions
bare
PSU-blended
PAN
nanofibers.
PSU/PAN
composite
a
diameter
range
222–392
nm.
terms
wettability,
measured
water
contact
angle
(WCA)
value
was
improved
from
(14
±
1)°
(156
6)°,
(160
4)°,
(158
4)°
after
being
PSU
solutions
having
concentrations
0.5,
1,
1.5,
2
wt
%,
respectively.
This
result
has
proven
can
be
tuned
hydrophilic
characteristics
simply
introducing
into
solution
prior
electrospinning,
where
small
concentration
0.5%
sufficient
provide
desired
effect.
Owing
its
low-cost
highly
efficient
process,
strategy
may
further
explored
for
other
types
polymer-based
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1017 - 1017
Published: July 31, 2024
Over
the
last
decade,
scientists
have
shifted
their
focus
to
development
of
smart
carriers
for
delivery
chemotherapeutics
in
order
overcome
problems
associated
with
traditional
chemotherapy,
such
as
poor
aqueous
solubility
and
bioavailability,
low
selectivity
targeting
specificity,
off-target
drug
side
effects,
damage
surrounding
healthy
tissues.
Nanofiber-based
systems
recently
emerged
a
promising
system
cancer
therapy
owing
unique
structural
functional
properties,
including
tunable
interconnected
porosity,
high
surface-to-volume
ratio
entrapment
efficiency
loading
capacity,
mass
transport
which
allow
controlled
targeted
delivery.
In
addition,
they
are
biocompatible,
biodegradable,
capable
surface
functionalization,
allowing
target-specific
release.
One
most
common
fiber
production
methods
is
electrospinning,
even
though
relatively
two-dimensional
(2D)
tightly
packed
structures
rates
limited
its
performance.
Forcespinning
an
alternative
spinning
technology
that
generates
high-throughput,
continuous
polymeric
nanofibers
3D
structures.
Unlike
forcespinning
fibers
by
centrifugal
forces
rather
than
electrostatic
forces,
resulting
significantly
higher
production.
The
functionalization
nanocarriers
on
can
result
anticancer
capabilities
be
activated
external
stimuli,
light.
This
review
addresses
current
trends
potential
applications
light-responsive
dual-stimuli-responsive
electro-
forcespun
therapy,
particular
emphasis
functionalizing
nanofiber
surfaces
developing
nano-in-nanofiber
emerging
dual-controlled
release
high-precision
tumor
targeting.
progress
prospective
diagnostic
therapeutic
discussed
context
combination
therapy.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 841 - 841
Published: Feb. 12, 2025
This
study
explores,
for
the
first
time,
application
of
electrospun
biobased
poly(butylene
2,5-furanoate)
(PBF)
and
poly(pentamethylene
(PPeF)
mats
in
biomedical
drug
delivery
fields,
through
a
careful
investigation
their
structure-property
relationship.
PBF
mats,
with
glass
transition
temperature
(Tg)
25-30
°C
an
as-spun
crystallinity
18.8%,
maintained
fibrous
structure
(fiber
diameter
~1.3
µm)
mechanical
properties
(stiffness
~100
MPa,
strength
~4.5
strain
at
break
~200%)
under
treatment
physiological
conditions
(37
°C,
pH
7.5).
In
contrast,
PPeF
being
amorphous
Tg
14
underwent
significant
densification,
geometrical
density
increasing
from
0.68
g/cm³
to
1.07
g/cm³,
which
depressed
specific
(i.e.,
normalized
by
density)
properties.
DSC
analysis
revealed
that
promoted
crystallization
(reaching
45.9%
crystallinity),
while
showed
limited,
but
interestingly
not
negligible,
structural
reorganization.
Both
materials
good
cell
adhesion
were
biocompatible,
lactate
dehydrogenase
release
exceeding
20%
after
48
h.
The
potential
was
evaluated
using
dexamethasone.
exhibited
controlled
profile,
~10%
4
h
~50%
20
demonstrates
versatility
these
biopolyesters
applications
highlights
impact
polymer
on
material
performance.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2459 - 2459
Published: Aug. 29, 2024
Nanomaterials
are
known
as
the
most
promising
materials
of
21st
century,
among
which
nanofibers
have
become
a
hot
research
and
development
topic
in
academia
industry
due
to
their
high
aspect
ratio,
specific
surface
area,
molecular
orientation,
crystallinity,
excellent
mechanical
properties,
many
other
advantages.
Electrospinning
is
important
preparation
method
for
thin
membranes
its
controllability,
versatility,
low
cost,
simplicity.
Adding
nanofillers
such
ceramics,
metals,
carbon
electrospinning
polymer
solutions
prepare
composites
can
further
improve
strength
multi-functionality
also
provide
possibilities
widespread
applications.
Based
on
rapid
field
composite
nanofibers,
this
review
focuses
polyurethane
(PU)-based
main
representative
reviews
latest
practical
applications
fields
sound-absorbing
materials,
biomedical
(including
tissue
engineering
implants,
drug
delivery
systems,
wound
dressings
anti-bacterial
health
etc.),
wearable
sensing
devices
energy
harvesters,
adsorbent
electromagnetic
shielding
reinforcement
materials.
Finally,
summary
performance-application
relationship
prospects
given.
This
expected
some
experience
theoretical
guidance
developments
related
fields.
Materials Advances,
Journal Year:
2024,
Volume and Issue:
5(16), P. 6489 - 6500
Published: Jan. 1, 2024
Core–shell
nanofibers
loaded
with
porphyrin
were
produced
to
act
as
localized
DDS
for
treating
cervical
cancer
using
PDT.
Porphyrin-loaded
electrospun
showed
a
higher
phototoxic
effect
against
tumor
cells
compared
non-tumor
ones.
