Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106391 - 106391
Published: Nov. 9, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 3, 2025
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 237 - 237
Published: Feb. 6, 2024
Microneedle (MN) technology is an optimal choice for the delivery of drugs via transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine and disease diagnostics. The biomedical device that offers many advantages including but not limited to painless experience, being time-effective, real-time sensing. This research implements additive manufacturing (AM) fabricate arrays advanced therapeutic applications. Stereolithography (SLA) was used six designs three aspect ratios. array included conical-shaped 100 needles (10 × 10 needle) in each array. microneedles were characterized using optical scanning electron microscopy evaluate dimensional accuracy. Further, mechanical insertion tests performed analyze strength skin penetration capabilities polymeric MN. MNs higher ratios had deformation characteristics suitable deeper levels beyond stratum corneum. both 0.3 mm 0.4 base diameters displayed consistent force–displacement behavior during skin-equivalent test. establishes guidelines fabricating high-accuracy low-cost 3D printing.
Language: Английский
Citations
15
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(5), P. 2294 - 2309
Published: April 24, 2024
Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered penetrate the epidermal skin barrier collect analytes from interstitial fluid, arising as safe, painless, effective alternative hypodermic needles. Although there are plenty of reviews on various types microneedles their use drug delivery systems, lack systematization application polymeric for diagnosis. In this review, we focus current state art field, while providing information safety, preclinical clinical trials, market distribution, outline what believe will future health monitoring.
Language: Английский
Citations
6
Sensors International, Journal Year: 2024, Volume and Issue: unknown, P. 100325 - 100325
Published: Dec. 1, 2024
Language: Английский
Citations
4
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 114687 - 114687
Published: March 1, 2025
Dissolving microneedles (MNs) are promising transdermal drug delivery systems that can effectively increase the absorption of drugs. They bypass first layer skin, stratum corneum (SC) and deliver drugs directly into dermis, by dissolving inside interstitial fluid releasing active. The traditional ways MN fabrication involve primarily micromolding, which basically uses silicone molds. Drugs polymer mixture solutions poured these molds after drying arrays carefully removed. In present study, a novel molding process was employed to fabricate MNs containing rivastigmine (RIV). RIV is available as an oral tablet patch. patch (Exelon®), used for managing Alzheimer's symptoms in mild moderate dementia, releases only about 50 % its content, raising concerns dose wastage, environmental impact, patient costs. Thus, selected model combining processes, Digital Light Processing Free-D Molding, Vacuum Compression Molding (VCM) Technique provided MeltPrep®. developed were evaluated regarding their physiochemical characteristics ability penetrate skin without breaking or creating fragments, they withstand forces up 600 N. visualized using optical microscopy, SEM, CLSM examine geometry, surface length (0.708 mm). Permeability studies verified significantly transportation across 9-fold. Histological analysis conducted ensure produced safe applications. Overall, study suggests molding, combination 3D printing VCM produce effective
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113794 - 113794
Published: May 1, 2025
Language: Английский
Citations
0
International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 119 - 126
Published: May 7, 2025
Microneedles (MNDs) have emerged as a transformative technology in transdermal drug delivery, offering minimally invasive alternative to traditional hypodermic needles. These microscale devices allow the direct delivery of medication into dermal layers by creating tiny punctures skin. This article looks in-depth at various types MNDs, including hollow, hydrogel-forming, coated, dissolvable, and solid along with associated manufacturing techniques. are used many medical disciplines reduce side effects, increase patient compliance, enhance efficacy. Examples these specialties include pain treatment, hormone administration, vaccine cosmetic surgeries. Despite their promising advantages, problems education, regulatory obstacles, scalability need be fixed. describes current status MNDs technology, discusses potential changes suggests future directions for study development.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106391 - 106391
Published: Nov. 9, 2024
Language: Английский
Citations
0