Recent approaches in nanotoxicity assessment for drug delivery applications: Challenges and prospects

Medicine in Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100204 - 100204

Published: Feb. 1, 2025

Language: Английский

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Noninvasive in-vivo human split-faced clinical investigation of nonanedioic acid loaded mesoporous silica nanoparticles immersed gel: revolutionizing cutaneous translational and cosmetical applications

Journal of Porous Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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Composite Hydrogel with Oleic Acid-Grafted Mesoporous Silica Nanoparticles for Enhanced Topical Delivery of Doxorubicin

Gels, Journal Year: 2024, Volume and Issue: 10(6), P. 356 - 356

Published: May 22, 2024

Mesoporous silica nanoparticles (MSNs) are inorganic nanocarriers presenting versatile properties and the possibility to deliver drug molecules via different routes of application. Their modification with lipids could diminish burst release profile for water-soluble molecules. In case oleic acid (OA) as a lipid component, an improvement in skin penetration can be expected. Therefore, present study, aminopropyl-functionalized MSNs were modified through carbodiimide chemistry subsequently incorporated into semisolid hydrogel dermal delivery. Doxorubicin served model drug. The FT-IR XRD analysis well ninhydrin reaction showed successful preparation proposed nanocarrier uniform particle size (352–449 nm) negative zeta potential. Transmission electron microscopy was applied evaluate any possible changes morphology. High encapsulation efficiency (97.6 ± 1.8%) achieved together sustained over 48 h. composite hydrogels containing OA-modified characterized by excellent physiochemical (pH 6.9; occlusion factor 53.9; spreadability 2.87 viscosity 1486 Pa·s) vitro permeation study 2.35 fold compared free cell studies that loading significantly improved doxorubicin’s cytotoxic effects toward epidermoid carcinoma cells (A431). All results suggest prepared has potential delivery doxorubicin treatment cancer.

Language: Английский

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A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125385 - 125385

Published: Feb. 1, 2025

Language: Английский

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From Nature to Nanotech: Unlocking Berberine’s Therapeutic Approaches

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106924 - 106924

Published: April 1, 2025

Language: Английский

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Structural elucidation and development of azelaic acid loaded mesoporous silica nanoparticles infused gel: Revolutionizing nanodrug delivery for cosmetics and pharmaceuticals

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29460 - e29460

Published: April 1, 2024

This research aimed to enhance dermal delivery and optimize depigmentation therapy by designing mesoporous silica nanoparticles (MSNs) encapsulating azelaic acid (AZA) within a gel matrix. The MSNs were prepared using the sol-gel method. After subsequent processes, including extraction drug loading, then elucidated through PDI, size, zeta-potential, entrapment efficiency, nitrogen adsorption assay, FE-SEM, thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction, tyrosinase inhibition employed assess formulation.

Language: Английский

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Formulation Design and Evaluation of Ginsenoside Compound K Nanostructured Lipid Carriers Based on Molecular Dynamics Simulations

Journal of Pharmaceutical Innovation, Journal Year: 2024, Volume and Issue: 19(6)

Published: Dec. 1, 2024

Language: Английский

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