Recent advances in surface decoration of nanoparticles in drug delivery

Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 11, 2024

Nanoparticulate delivery systems have been attracting attention in pharmaceutical sciences for enhanced drug bioavailability and targeted delivery. Specifically, these can enhance the solubility of poorly water-soluble drugs, protect therapeutic agents from degradation, prolong circulation time body, control release, facilitate precise targeting drugs to specific tissues or cells. However, once administered into nanoparticles often encounter significant challenges that affect their efficacy safety, such as issues with stability, biocompatibility, targeting. The surface properties are one most important features they greatly influence interactions between themselves biological targets. Key characteristics, charge, hydrophobicity, presence functional groups, determine how behave environments, thereby influencing cellular uptake, ability avoid immune clearance. Modification nanoparticle has shown be an effective approach modulate physicochemical nanoparticles, achieving desired vivo . This review aims summarize recent advances decoration emphasis on improved colloidal reduced toxicity, future perspectives modification approaches also discussed.

Language: Английский

Solvent-Free Microfluidic Fabrication of Antimicrobial Lipid Nanoparticles

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Antimicrobial lipid nanoparticles composed of monoglycerides offer a promising strategy to inhibit membrane-enveloped viral and bacterial pathogens. However, previous efforts mainly focused on fabricating from long-chain monoglycerides, which lack intrinsic antimicrobial activity but contribute nanoparticle stability structural integrity. In contrast, shorter-chain often exhibit potent effects do not self-assemble into colloidally stable lose efficacy upon dilution. To overcome these limitations incorporate configuration, we report solvent-free microfluidic fabrication that combines the functional characteristics different prepare interfacially active, monoglyceride-based with mixed compositions display antibacterial activity. Unlike conventional mixing methods rely volatile organic solvents, our approach utilizes pharmaceutical-grade materials does require solvent removal, hence eliminating need for dialysis step postfabrication. Dynamic light scattering (DLS) zeta potential measurements verified fabricated had ∼250–350 nm diameters exhibited high colloidal whereas against Staphylococcus aureus bacteria depended strongly composition. Nanoparticles glycerol monooleate alone were inactive, while inclusion monolaurate slightly enhanced Surprisingly, further addition monobehenate or dibehenate─previously considered inactive components are used improve cohesion─boosted potency by up 270-fold. Biophysical experiments showed greater induced more pronounced membrane disruption, as observed in quartz crystal microbalance-dissipation electrochemical impedance spectroscopy measurements. These findings demonstrate combining can significantly enhance lipid-based underscore biophysics approaches guide performance optimization, highlighting capability tune membrane-disruptive properties physiologically relevant pH conditions.

Language: Английский

Mucoadhesive and Drug Release of Cholic Acid Based Thiomeric Micelles and Encapsulated Silver and Gold Nanoparticles for Anticancer Studies

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135363 - 135363

Published: Sept. 1, 2024

Language: Английский