Nanoparticle-Based Dry Powder Inhaler Containing Ciprofloxacin for Enhanced Targeted Antibacterial Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 486 - 486

Published: April 7, 2025

Background: Ciprofloxacin (CIP) is a poorly water-soluble fluoroquinolone-type antibiotic that can be useful in the treatment of lung infections. When drugs are delivered directly to lungs, smaller dosage needed achieve desired effect compared oral administration. Moreover, application nanoparticles potentially enhances effectiveness treatments while lowering possible side effects. Therefore, we aimed develop “nano-in-micro” structured dry powder inhaler formulation containing CIP. Methods: A two-step preparation method was used. Firstly, nanosuspension first prepared using high-performance planetary mill by wet milling. After addition different additives (leucine and mannitol), solid formulations were created spray drying. The DPI samples analyzed laser diffraction, nanoparticle tracking analysis, scanning electron microscopy, X-ray differential calorimetry. solubility vitro dissolution tests artificial fluid aerodynamic investigations (Spraytec® device, Andersen Cascade Impactor) carried out. Results: (D50: 140.0 ± 12.8 nm) successfully particle size reduction method. DPIs suitable for inhalation based on diameter their spherical shape. Improved surface area amorphization after processes led faster drug release. excipient-containing systems characterized large deposition (fine fraction around 40%) (between 3 4 µm). Conclusions: We have formulated nanosized antibiotic-containing pulmonary delivery, which could provide potential patients with respiratory

Language: Английский

Polycomponent metal-organic frameworks of substituent polydispersion hydroxypropyl-β-cyclodextrin as inhalable drug carrier

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123696 - 123696

Published: May 1, 2025

Language: Английский

Breath and Beyond: Advances in Nanomedicine for Oral and Intranasal Aerosol Drug Delivery

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1742 - 1742

Published: Dec. 23, 2024

Designing and standardizing drug formulations are crucial for ensuring the safety efficacy of medications. Nanomedicine utilizes nano delivery systems advanced nanodevices to address numerous critical medical challenges. Currently, oral intranasal aerosol (OIADD) is primary method treating respiratory diseases worldwide. With advancements in disease understanding development aerosolized systems, application OIADD has exceeded its traditional boundaries, demonstrating significant potential treatment non-respiratory conditions as well. This study provides a comprehensive overview applications treatment. It examines key challenges limiting nanomedicines formulation processes, devices explores latest these areas. review aims offer valuable insights researchers involved platforms.

Language: Английский