Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading DOI
Zhiyuan Zheng, Yue Wu,

Ayyaz Ahmad

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 19194 - 19210

Published: Aug. 12, 2024

Lyophilization is a prevalent technique for preparing paclitaxel (PTX) clinical formulations. However, the instability of PTX nanoparticles poses challenges in producing lyophilized Such an involves maintaining stable dispersions and structural integrity during lyophilization. To tackle these issues, flash nanoprecipitation method employed to prepare highly loaded lyophilizable diPTX-SS nanoparticles, achieving over month nanosuspension stability 91 wt % loading capacity. Furthermore, adjusting concentrations stabilizer ratios allows controlled nanoparticle preparation with surface structures suitable The hybridization PLGA-PEG DSPE-PEG increases PEG layer content, creating corona-like outer that maintains lyophilization, ensures excellent redispersibility postlyophilization without excessive cryoprotectants. Additionally, responsive release behavior, along vitro vivo experiments, confirms hybrid effectively suppress tumor growth vascular endothelial proliferation, offering insights formulation development.

Language: Английский

Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics DOI Creative Commons
Dilip Kumar Chandra, Awanish Kumar, Chinmaya Mahapatra

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

Citations

2
Construction and Characterization of 5,6-O-Isopropylidene-L-Ascorbic Acid-Loaded Silver and Manganese Dioxide Nanoparticles: Cytotoxicity Study, Antibacterial, and Antioxidant Activities DOI
Mouhaned Y. Al-darwesh,

Layth L. Hamid,

Sattar S. Ibrahim

et al.

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130517 - 130517

Published: Feb. 1, 2025

Language: Английский

Citations

1
BOX-BEHNKEN OPTIMIZATION OF MELOXICAM MICROCAPSULE SCAFFOLDS FOR PRECISION DRUG DELIVERY IN ARTHRITIS: ENHANCED STABILITY, EFFECTIVE STERILIZATION, AND IN VIVO THERAPEUTIC POTENTIAL DOI Open Access

S. Ganesh Kumar,

M. Mothilal

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 410 - 425

Published: Jan. 7, 2025

Objective: This study aims to develop and evaluate an innovative implantable drug delivery system using gelatin microspheres loaded with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), namely meloxicam (MXM), integrated into a scaffold. is designed enhance efficiency sustain release. Methods: MXM-loaded 1:1 ratio of Poly Lactic Acid (PLA) Lacto Glycolic (PLGA) were optimized for size, yield, efficiency, Gelatin scaffolds as rod-shaped implants, tested stability degradation in pH 7.4 4.0 buffers at 37 °C 100 d, sterilized γ-radiation. Implants evaluated rabbits, blood samples analyzed via High-Performance Liquid Chromatography (HPLC) pharmacokinetic parameters statistically (P<0.05). Results: The PLA PLGA demonstrated favorable characteristics such smaller particle sizes, high efficient entrapment Optimization Design Expert resulted highly desirable scaffolds, evidenced by desirability factor close one across all assessed variables. exhibited robust physicochemical properties, including sustained release over extended period, highlighting their potential diverse biomedical applications. showed greater buffer solutions contrast higher mass loss acidic environments (14.4% vs. 9.66%). γ-Radiation sterilization effectively prevented microbial contamination. In vivo studies confirmed MXM detection plasma, Scaffold-MXM (iS-MMS-17) (optimized scaffold) showing mean Cmax values significant Area Under Curve (AUC) parameters, suggesting its effective therapy. Conclusion: found that the strong properties release, making them suitable use. more stable than 4.0, γ-radiation detection, iS-MMS-17 promising pain arthritis

Language: Английский

Citations

0
Unraveling the effect of water and ethanol on ibuprofen nanoparticles formation DOI Creative Commons

M.G. Anagha,

Piotr Kubisiak, Paulina Chytrosz-Wróbel

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127563 - 127563

Published: April 1, 2025

Language: Английский

Citations

0
Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading DOI
Zhiyuan Zheng, Yue Wu,

Ayyaz Ahmad

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 19194 - 19210

Published: Aug. 12, 2024

Lyophilization is a prevalent technique for preparing paclitaxel (PTX) clinical formulations. However, the instability of PTX nanoparticles poses challenges in producing lyophilized Such an involves maintaining stable dispersions and structural integrity during lyophilization. To tackle these issues, flash nanoprecipitation method employed to prepare highly loaded lyophilizable diPTX-SS nanoparticles, achieving over month nanosuspension stability 91 wt % loading capacity. Furthermore, adjusting concentrations stabilizer ratios allows controlled nanoparticle preparation with surface structures suitable The hybridization PLGA-PEG DSPE-PEG increases PEG layer content, creating corona-like outer that maintains lyophilization, ensures excellent redispersibility postlyophilization without excessive cryoprotectants. Additionally, responsive release behavior, along vitro vivo experiments, confirms hybrid effectively suppress tumor growth vascular endothelial proliferation, offering insights formulation development.

Language: Английский

Citations

1