For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101626 - 101626

Published: March 1, 2025

Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.

Language: Английский

Targeting breast tumor extracellular matrix and stroma utilizing nanoparticles

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Language: Английский