Protective Effects of Chitosan Oligosaccharide Against Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress in Bovine Mammary Epithelial Cells

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 31 - 31

Published: Jan. 9, 2025

Chitosan oligosaccharide (COS) is receiving increasing attention as a feed additive in animal production. COS has variety of biological functions, including anti-inflammatory and antioxidant activities. Mastitis major disease dairy cows that significant impact on welfare Hence, this research aimed to investigate the mechanism lipopolysaccharide (LPS)-stimulated inflammatory response oxidative stress bovine mammary epithelial cells (BMECs). In study, results demonstrated protected BMECs from induced by LPS restraining excessive production toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β). treatment also suppressed reactive oxygen species (ROS) restored enzyme activity under LPS-induced conditions. Furthermore, promote nuclear factor erythroid 2-related 2 (Nrf2) expression inhibit TLR4 levels p65 IκBα phosphorylation exposed LPS. summary, demonstrate protective depend TLR4/nuclear factor-κB (NF-κB) Nrf2 signaling pathways, indicating could serve natural agents for alleviating mastitis.

Language: Английский

Metal-based nanoplatforms for enhancing the biomedical applications of berberine: current progress and future directions

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: March 20, 2025

The isoquinoline alkaloid berberine, a bioactive compound derived from various plants, has demonstrated extensive therapeutic potential. However, its clinical application is hindered by poor water solubility, low bioavailability, rapid metabolism, and insufficient targeting. Metal-based nanoplatforms offer promising solutions, enhancing drug stability, controlled release, targeted delivery. This review comprehensively explores the synthesis, physicochemical properties, biomedical applications of metal-based nanocarriers, including gold, silver, iron oxide, zinc selenium, magnetic nanoparticles, for berberine delivery to improve berberine's efficacy. Recent advancements in nanocarrier systems have significantly improved cellular uptake, extending circulation time, enabling site-specific encounter several limitations potential toxicity, limited large-scale productions, regulatory constraints. Addressing these necessitates studies on biocompatibility, long-term safety, translation. By summarizing latest innovations perspectives, this aims guide future research toward optimizing berberine-based nanomedicine

Language: Английский