Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

Nutrition & Metabolism, Journal Year: 2022, Volume and Issue: 19(1)

Published: March 18, 2022

Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to syndrome and its related diseases. Whether serum methionine levels are associated with NAFLD remains unclear. The study aimed assess association between NAFLD. This cross-sectional included a total 2814 individuals aged 40-75 years old. All participants underwent anthropometric measurements, laboratory tests, dietary assessment abdominal ultrasonography. Multivariable logistic regression analysis was performed estimate Overall, 1446 1368 without were enrolled in this study. Participants had significantly higher S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) homocysteine (Hcy) levels, lower S-adenosylmethionine/S-adenosylhomocysteine (SAM/SAH) ratio than those (all P < 0.001). After adjusting multiple confounders, odds ratios (95% confidence interval) for quartile 4 versus 1 SAH, Hcy SAM/SAH 1.65 (1.27-2.14), 1.63 (1.26-2.12) 0.63 (0.49-0.83), respectively trend 0.01). In addition, correlated degree steatosis Elevated may be independently presence middle-aged elder Chinese.

Language: Английский

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Diabetic Nephropathy and Gaseous Modulators

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1088 - 1088

Published: May 12, 2023

Diabetic nephropathy (DN) remains the leading cause of vascular morbidity and mortality in diabetes patients. Despite progress understanding diabetic disease process advanced management nephropathy, a number patients still to end-stage renal (ESRD). The underlying mechanism needs be clarified. Gaseous signaling molecules, so-called gasotransmitters, such as nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), have been shown play an essential role development, progression, ramification DN depending on their availability physiological actions. Although studies gasotransmitter regulations are emerging, evidence revealed aberrant level gasotransmitters with diabetes. In studies, different donors implicated ameliorating dysfunction. this perspective, we summarized overview recent advances relevance gaseous molecules multifaceted interaction other potential factors, extracellular matrix (ECM), severity modulation DN. Moreover, perspective present review highlights possible therapeutic interventions dreaded disease.

Language: Английский

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Probiotic co-supplementation with absorbent smectite for pancreatic beta-cell function in type 2 diabetes: a secondary-data analysis of a randomized double-blind controlled trials

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Introduction There is growing evidence from animal and clinical studies suggesting probiotics can positively affect type 2 diabetes (T2D). In a previous randomized study, we found that administering live multistrain probiotic absorbent smectite once day for eight weeks to patients with T2D could reduce chronic systemic inflammatory state, insulin resistance, waist circumference improve the glycemic profile. However, there lack of supporting efficacy co-supplementation on pancreatic β-cell function in T2D. Aim This secondary analysis aimed assess effectiveness an alive vs placebo patients. Material methods We performed previously published controlled trial (NCT04293731, NCT03614039) involving 46 The main inclusion criteria were presence dysfunction (%B&lt;60%) therapy alone or combined oral anti-diabetic drugs. primary outcome was assessing as change C-peptide %B. Results observed only tendency improving (44.22 ± 12.80 55.69 25.75; р=0.094). probiotic-smectite group confirmed by fasting glycemia decreased 14% (p=0.019), HbA1c – 5% (p=0.007), HOMA-2 17% (p=0.003) increase sensitivity 23% (p=0.005). Analysis cytokine profile showed statistical differences after treatment concentration both pro-inflammatory cytokines: IL-1β (22.83 9.04 19.03 5.57; p=0.045) TNF-α (31.25 11.32 26.23 10.13; p=0.041). Conclusion Adding supplement slightly improved reduced glycemic-related parameters suggests adjusting gut microbiota be promising warrants further investigation through more extensive studies.

Language: Английский

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Linking homocysteine and ferroptosis in cardiovascular disease: insights and implications

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(11-12), P. 1944 - 1958

Published: July 23, 2024

Language: Английский

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Serum Metabolomics Benefits Discrimination Kidney Disease Development in Type 2 Diabetes Patients

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: May 9, 2022

Background Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease, raising a considerable burden worldwide. Recognizing novel biomarkers by metabolomics can shed light on new biochemical insight to benefit DKD diagnostics and therapeutics. We hypothesized that serum metabolites serve as in progression DKD. Methods A cross-sectional study 1,043 plasma untargeted LC/MS among 89 participants identified associations between proteinuria severity difference. Pathway analysis from differently expressed was used determine perturbed metabolism pathways. The results were replicated an independent, cohort 83 individuals. Correlation prediction values examine association level amount. Results Diabetes, diabetic with different ranges have shown patterns. Cysteine methionine pathway, Taurine hypotaurine pathway distinguishable existence DC (diabetes controls without disease), proteinuria. Two interesting tetrapeptides (Asn-Met-Cys-Ser Asn-Cys-Pro-Pro) circulating levels elevated progression. Conclusions These findings underscore provide us perspectives identify some clinically relevant physiopathologic

Language: Английский

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