A Direct Analysis of β-N-methylamino-l-alanine Enantiomers and Isomers and Its Application to Cyanobacteria and Marine Mollusks DOI Creative Commons
James S. Metcalf, Sandra Anne Banack, Peter B. Wyatt

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(11), P. 639 - 639

Published: Nov. 1, 2023

Of the wide variety of toxic compounds produced by cyanobacteria, neurotoxic amino acid β-N-methylamino-l-alanine (BMAA) has attracted attention as a result its association with chronic human neurodegenerative diseases such ALS and Alzheimer’s. Consequently, specific detection methods are required to assess presence BMAA isomers in environmental clinical materials, including cyanobacteria mollusks. Although separation β-amino-N-methylalanine (BAMA), N-(2-aminoethyl)glycine (AEG) 2,4-diaminobutyric (DAB) from been demonstrated during routine analysis, further compounding factor is potential enantiomers for some these isomers. Current analytical mostly do not discriminate between enantiomers, chiral configuration still largely unexplored. To understand occurrence D-BMAA UPLC-MS/MS method was developed separate determine enantiomeric endogenous free marine Lyngbya mat two mussel reference materials. After extraction, purification derivatization N-(4-nitrophenoxycarbonyl)-l-phenylalanine 2-methoxyethyl ester ((S)-NIFE), both L- were identified acids cyanobacterial whereas only L-BMAA tissues. The finding biological materials raises questions concerning source role neurological disease.

Language: Английский

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy DOI
Shi Huang,

Lingzi Zuo,

Liexiong Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 7021 - 7032

Published: March 19, 2024

Lakes and reservoirs worldwide are experiencing a growing problem with harmful cyanobacterial blooms (HCBs), which have significant implications for ecosystem health water quality. Algaecide is an effective way to control HCBs effectively. In this study, we applied active substructure splicing strategy rapid discovery of algicides. Through strategy, first optimized the structure lead compound S5, designed synthesized three series thioacetamide derivatives (series A, B, C), then evaluated their algicidal activities. Finally, A3 excellent performance was found, accelerated process discovering developing new The biological activity assay data showed that had inhibitory effect on M. aeruginosa. FACHB905 (EC50 = 0.46 μM) Synechocystis sp. PCC6803 0.95 μM), better than commercial algicide prometryn (M. FACHB905, EC50 6.52 μM; PCC6803, 4.64 as well S5 8.80 7.70 μM). relationship between surface electrostatic potential, chemical reactivity, global electrophilicity compounds activities discussed by density functional theory (DFT). Physiological biochemical studies shown might affect photosynthesis pathway antioxidant system in cyanobacteria, resulting morphological changes cells. Our work demonstrated be promising candidate development novel algicides provided skeleton subsequent

Language: Английский

Citations

8
A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health DOI Creative Commons
Albano Pinto, Inês P. E. Macário, Sérgio Marques

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175431 - 175431

Published: Aug. 14, 2024

Harmful algal blooms and the toxins produced during these events are a human environmental health concern worldwide. Saxitoxin its derivatives potent natural aquatic neurotoxins by certain freshwater cyanobacteria marine algae species bloom events. Saxitoxins effects on well studied, however biota still largely unexplored. This work aims at evaluating of pulse acute exposure (24 h) model cladoceran Daphnia magna to 30 μg saxitoxin L

Language: Английский

Citations

5
Marine Toxins as Pharmaceutical Treasure Troves: A Focus on Saxitoxin Derivatives from a Computational Point of View DOI Creative Commons
Norma Flores-Holguı́n, Joan S. Salas‐Leiva, Erick J. Núñez-Vázquez

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(1), P. 275 - 275

Published: Jan. 4, 2024

This work highlights the significant potential of marine toxins, particularly saxitoxin (STX) and its derivatives, in exploration novel pharmaceuticals. These produced by aquatic microorganisms collected bivalve mollusks other filter-feeding organisms, offer a vast reservoir chemical biological diversity. They interact with sodium channels physiological processes, affecting various functions organisms. Exposure to these toxins can lead symptoms ranging from tingling sensations respiratory failure cardiovascular shock, STX being one most potent. The structural diversity categorized into carbamate, N-sulfocarbamoyl, decarbamoyl, deoxydecarbamoyl offers for drug development. research described this aimed computationally characterize 18 exploring their reactivity properties within sponges using conceptual density functional theory (CDFT) techniques. Additionally, pharmacokinetic properties, bioavailability, drug-likeness scores were assessed. outcomes parameters calculated via CDFT as well estimated ADME derived computational tools. While they may not align directly, integration distinct datasets enriches our comprehensive understanding compound’s applications. Thus, study holds promise uncovering new pharmaceutical candidates considered toxins.

Language: Английский

Citations

4
Warfare under the waves: a review of bacteria-derived algaecidal natural products DOI
Wei-Yang Bao, Spencer J. Williams,

Mary Courtney

et al.

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Covering: 1960s to 2024Harmful algal blooms pose a major threat aquatic ecosystems and can impact human health. The frequency intensity of these has increased over recent decades, driven primarily by climate change an increase in nutrient runoff. Algal often produce toxins that contaminate water sources, disrupt fisheries, harm These may also result oxygen-deprived environments leading mass fish deaths threaten the survival other life. In freshwater estuarine ecosystems, traditional chemical strategies mitigate include use herbicides, metal salts, or oxidants. Though effective, agents are non-selective, toxic species, cause loss biodiversity. They persist contaminating food web providing impetus for cost-effective, targeted algal-control methods protect ecosystems. marine harmful even more challenging treat due lack scalable solutions challenge dispersal control open ocean settings. Natural products derived from algae-bacteria interactions have led evolution diverse bacteria-derived algaecidal natural products, which highly potent, species specific potential combating blooms. provide valuable starting points development eco-friendly algae methods. This review provides comprehensive overview all bacterial algaecides their activities, categorized into two groups: (1) produced ecologically significant associations between bacteria algae, (2) with potentially coincidental activity but without ecological role bacteria-algae interactions. contributes better understanding ecology parasitic algal-bacterial interactions, "the warfare under waves", highlights applications

Language: Английский

Citations

0
Biosensors for the Detection of Biotoxins in Finfish and Shellfish DOI

Tiasha Dutta,

Sushil Kumar Mandal, Jayanta Kumar Biswas

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanomaterial-based advanced sensors for rapid marine biotoxin detection: An ethical and promising alternative DOI
Ruth Stephanie,

Xiaomiao Ruan,

Suresh Kumar Kailasa

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118255 - 118255

Published: April 1, 2025

Language: Английский

Citations

0
Design of a Fractional-Order Environmental Toxin-Plankton System in Aquatic Ecosystems: A Novel Machine Predictive Expedition with Nonlinear Autoregressive Neuroarchitectures DOI

Muhammad Junaid Ali Asif Raja,

Amir Sultan, Chuan‐Yu Chang

et al.

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123640 - 123640

Published: April 1, 2025

Language: Английский

Citations

0
Comparative analysis of phytoplankton diversity using microscopy and metabarcoding: insights from an eLTER station in the Northern Adriatic Sea DOI Creative Commons
Francesca Neri, Marika Ubaldi, Stefano Accoroni

et al.

Hydrobiologia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

Citations

2
Coral microbiomes from the Atlantic and Indo-Pacific oceans have the same alpha diversity but different composition DOI Creative Commons
Maria E. A. Santos, James Davis Reimer, Bogdan A. Kiriukhin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 17, 2024

Corals are early-branching animals highly reliant on diverse symbionts for growth and reproduction. Most coral groups, including stony corals hydrocorals, exhibit deep genetic divergence between the Atlantic (ATO) Indo-Pacific (IPO) oceans, hampering their direct comparison. Although sibling zoanthid species (Hexacorallia: Zoantharia) deviate from this pattern, symbioses have so far only been studied local scales. Here, we examined microbiomes of Palythoa caribaeorum ATO P. tuberculosa IPO. Our extensive geographical sampling metabarcoding revealed that similar alpha diversity in both oceans. The primary exceptions symbiodiniacean Cladocopium Chlamydiae bacteria, which mirror global patterns corals. Despite distinct overall microbial compositions some regions shared remarkably communities, hinting at importance symbiont phylogeny function. Finally, explore shift commensal/mutualistic microbes to opportunistic pathogens, crucial amid ongoing environmental changes.

Language: Английский

Citations

0
Lesser-Known Cyanotoxins: A Comprehensive Review of Their Health and Environmental Impacts DOI Creative Commons

Molham Al Haffar,

Ziad Fajloun, Sami T. Azar

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 551 - 551

Published: Dec. 19, 2024

Cyanobacteria, also known as blue-green algae, are a diverse phylum of photosynthetic, Gram-negative bacteria and one the largest microbial taxa. These organisms produce cyanotoxins, which secondary metabolites that can have significant impacts on both human health environment. While toxins like Microcystins Cylindrospermopsins well-documented been extensively studied, other including those produced by Lyngbya Nostoc, remain underexplored. lesser-known cause various issues in humans, neurotoxicity, hepatotoxicity, dermatotoxicity, each through distinct mechanisms. Moreover, recent studies shown cyanobacteria be aerosolized transmitted air over long distances, providing an additional route for exposure to their harmful effects. However, it remains area requires much more investigation accurately assess risks develop appropriate public guidelines. In addition direct toxins, lead algal blooms, pose further wildlife health, global concern. There is limited knowledge about these highlighting need research understand clinical manifestations improve society’s preparedness associated risks. This work aims review existing literature underexplored with intoxication, elucidate relevance, address challenges cyanobacterial research, provide guidance mitigating adverse

Language: Английский

Citations

0