Potential benefits of ginseng against COVID-19 by targeting inflammasomes

Journal of Ginseng Research, Journal Year: 2022, Volume and Issue: 46(6), P. 722 - 730

Published: April 5, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs system multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes inflammasome-mediated inflammatory signaling pathways, are key determinants of hyperinflammation storm in COVID-19 patients. Additionally, inhibits inflammasome activation to evade host's antiviral immunity. Therefore, regulating initiation has received increasing attention as a preventive measure Ginseng its active constituents, ginsenosides saponins, improve immune exert anti-inflammatory effects by targeting stimulation. this review discussed potential therapeutic roles ginseng based on regulatory role

Language: Английский

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Bidirectional effects and mechanisms of traditional Chinese medicine

Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 298, P. 115578 - 115578

Published: July 31, 2022

Language: Английский

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Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 7, 2024

Recent research on traditional Chinese medicine (TCM) saponin pharmacokinetics has revealed transformative breakthroughs and challenges. The multicomponent nature of TCM makes it difficult to select representative indicators for pharmacokinetic studies. clinical application saponins is limited by their low bioavailability short half-life, resulting in fluctuating plasma concentrations. Future directions should focus novel compounds utilizing colon-specific delivery osmotic pump systems enhance oral bioavailability. Optimizing drug combinations, such as ginsenosides with aspirin, shows therapeutic potential. Rigorous validation essential practical applications. This review emphasizes a era research, highlighting the need validation. pharmacokinetics, guided principles, are development, multidisciplinary approaches comprehensive understanding. provides theoretical basis new drugs supports rational medication.

Language: Английский

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Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways

Journal of Ginseng Research, Journal Year: 2022, Volume and Issue: 46(3), P. 489 - 495

Published: Feb. 24, 2022

Although ginsenosides and saponins in Korea red ginseng (KRG) shows various pharmacological roles, their roles the inflammatory response are little known. This study investigated anti-inflammatory role of identified from KRG saponin fraction (RGSF) potential mechanism macrophages.The ginsenoside composition RGSF was by high-performance liquid chromatography (HPLC) analysis. An effect its mechanisms were studied using nitric oxide (NO) prostaglandin E2 (PGE2) production assays, mRNA expression analyses genes cytokines, luciferase reporter gene assays transcription factors, Western blot signaling pathways lipopolysaccharide (LPS)-treated RAW264.7 cells.HPLC analysis types amounts panaxadiol RGSF. reduced generation molecules levels enzymes cytokines LPS-treated cells. Additionally, inhibited NF-κB AP-1 suppressing both transcriptional factors cells.RGSF contains that have action via restraining macrophages during responses.

Language: Английский

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Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1077 - 1077

Published: Jan. 5, 2023

We previously reported that Korean red ginseng (KRG) exerts an anti-inflammatory role through inhibiting caspase-11 non-canonical inflammasome in macrophages; however, the components responsible for remained unclear. This study explored activity of KRG saponin fraction (KRGSF) inflammasome-activated macrophages. KRGSF inhibited pyroptosis, pro-inflammatory cytokine secretion, and inflammatory mediator production J774A.1 cells. A mechanism revealed KRGSF-induced action was mediated via suppressing proteolytic activation gasdermin D (GSDMD) Moreover, increased survival lethal septic mice. Taken together, these results reveal KRGSF-mediated with a novel mechanism, by

Language: Английский

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Brain plasticity and ginseng

Journal of Ginseng Research, Journal Year: 2024, Volume and Issue: 48(3), P. 286 - 297

Published: March 26, 2024

Brain plasticity refers to the brain's ability modify its structure, accompanied by functional changes. It is influenced learning, experiences, and dietary factors, even in later life. Accumulated researches have indicated that ginseng may protect brain enhance function pathological conditions. There a compelling need for more comprehensive understanding of ginseng's role physiological condition because many individuals without specific diseases seek improve their health incorporating into routines. This review aims deepen our how affects people undergoing normal aging process. We provided summary studies reported impact on related factors human clinical studies. Furthermore, we explored focused molecular mechanisms underpinning influence contributing plasticity. Evidences indicate has potential context mediating both central peripheral systems, thereby expecting age-related declines function. Moreover, given modern western diet can damage neuroplasticity long term, be beneficial supplement better health.

Language: Английский

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A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages

Journal of Ginseng Research, Journal Year: 2021, Volume and Issue: 46(5), P. 675 - 682

Published: Dec. 28, 2021

Language: Английский

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Prediction performance and reliability evaluation of three ginsenosides in Panax ginseng using hyperspectral imaging combined with a novel ensemble chemometric model

Food Chemistry, Journal Year: 2023, Volume and Issue: 430, P. 136917 - 136917

Published: July 27, 2023

Language: Английский

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A Focused Review on Molecular Signalling Mechanisms of Ginsenosides Anti-Lung Cancer and Anti-inflammatory Activities

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 23(1), P. 3 - 14

Published: March 22, 2022

Background: Ginseng (Panax ginseng Meyer) is a cultivated medicinal herb that has been widely available in the Asian region since last century. root used worldwide Oriental medicine. Currently, global mortality and infection rates for lung cancer inflammation are significantly increasing. Therefore, various preventative methods related to activity of ginsenosides have as well inflammation. Methods: Web-based searches were performed on Web Science, Springer, PubMed, Scopus. A statistical analysis was also conducted show current ratio affected cases death from around world. Results: Ginsenosides regulate enzymes participate tumor growth migration, such nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (p38 MAPK), c-Jun N-terminal (JNK), extracellular signalregulated kinases 1/2 (ERK1/2), gelatinase network metalloproteinase-2 (MMP-2/9) activator 1 (AP-1). In addition, possess anti-inflammatory effects by inhibiting formation proinflammatory cytokines (tumor necrosis factor-α) (TNF-α) interleukin-1β (IL-1β) controlling activities inflammatory signalling pathways, NF-κB, Janus kinase2/signal transducer, transcription 3 (Jak2/Stat3). Conclusion: several vitro vivo models, P. showed potential beneficial treatment. this review, we provide detailed up-to-date summary research evidence antilung protective their molecular mechanisms.

Language: Английский

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Roles of ginsenosides in sepsis

Journal of Ginseng Research, Journal Year: 2022, Volume and Issue: 47(1), P. 1 - 8

Published: May 7, 2022

The herbal medication Panax ginseng Meyer has widespread use in China, Korea, and other parts of the world. main constituents are ginsenosides, which include over 30 different triterpene saponins. It been found that ginsenosides their metabolites including Rg1, compound K, Rb1, Re, Rg3, Rg5 exert anti-inflammatory activities by binding to glucocorticoid receptor, modulating inflammation-related signaling, NF-κB MAPK reducing levels pro-inflammatory cytokines. Here, we review recent literature on molecular actions sepsis, suggesting ways they may be used prevent treat disease.

Language: Английский

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