Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 29, 2024
Remarkable
progress
has
been
achieved
in
sepsis
treatment
recent
times,
the
mortality
rate
of
experienced
a
gradual
decline
as
result
prompt
administration
antibiotics,
fluid
resuscitation,
and
implementation
various
therapies
aimed
at
supporting
multiple
organ
functions.
However,
there
is
still
significant
room
for
improvement.
The
septic
patients,
22.5%,
unacceptably
high,
accounting
19.7%
all
global
deaths.
Therefore,
it
crucial
to
thoroughly
comprehend
pathogenesis
order
enhance
clinical
diagnosis
methods.
Here,
we
summarized
classic
mechanisms
progression,
activation
signal
pathways,
mitochondrial
quality
control,
imbalance
pro-and
anti-
inflammation
response,
diseminated
intravascular
coagulation
(DIC),
cell
death,
presented
latest
research
findings
each
mechanism
identify
potential
therapeutic
targets
within
mechanism.
Journal of Ginseng Research,
Journal Year:
2022,
Volume and Issue:
46(6), P. 722 - 730
Published: April 5, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
the
pathogenic
virus
that
causes
disease
2019
(COVID-19),
with
major
symptoms
including
hyper-inflammation
and
cytokine
storm,
which
consequently
impairs
system
multiple
organs,
or
even
cause
death.
SARS-CoV-2
activates
inflammasomes
inflammasome-mediated
inflammatory
signaling
pathways,
are
key
determinants
of
hyperinflammation
storm
in
COVID-19
patients.
Additionally,
inhibits
inflammasome
activation
to
evade
host's
antiviral
immunity.
Therefore,
regulating
initiation
has
received
increasing
attention
as
a
preventive
measure
Ginseng
its
active
constituents,
ginsenosides
saponins,
improve
immune
exert
anti-inflammatory
effects
by
targeting
stimulation.
this
review
discussed
potential
therapeutic
roles
ginseng
based
on
regulatory
role
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 28, 2023
The
primary
processed
product
of
Panax
ginseng
C.A.
Meyer
(
P.
)
is
red
ginseng.
As
technology
advances,
new
products
have
arisen.
Red
products,
e.g.,
traditional
ginseng,
sun
black
fermented
and
puffed
are
commonly
used
in
herbal
medicine.
Ginsenosides
the
major
secondary
metabolites
.
constituents
significantly
changed
during
processing,
several
pharmacological
activities
dramatically
increased
compared
to
white
In
this
paper,
we
aimed
review
ginsenosides
various
transformation
law
some
clinical
trials
products.
This
article
will
help
highlight
diverse
properties
aid
future
development
industrialization.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1077 - 1077
Published: Jan. 5, 2023
We
previously
reported
that
Korean
red
ginseng
(KRG)
exerts
an
anti-inflammatory
role
through
inhibiting
caspase-11
non-canonical
inflammasome
in
macrophages;
however,
the
components
responsible
for
remained
unclear.
This
study
explored
activity
of
KRG
saponin
fraction
(KRGSF)
inflammasome-activated
macrophages.
KRGSF
inhibited
pyroptosis,
pro-inflammatory
cytokine
secretion,
and
inflammatory
mediator
production
J774A.1
cells.
A
mechanism
revealed
KRGSF-induced
action
was
mediated
via
suppressing
proteolytic
activation
gasdermin
D
(GSDMD)
Moreover,
increased
survival
lethal
septic
mice.
Taken
together,
these
results
reveal
KRGSF-mediated
with
a
novel
mechanism,
by
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2091 - 2091
Published: Feb. 8, 2024
Inflammasomes
are
intracellular
multiprotein
complexes
that
activate
inflammatory
signaling
pathways.
comprise
two
major
classes:
canonical
inflammasomes,
which
were
discovered
first
and
activated
in
response
to
a
variety
of
pathogen-associated
molecular
patterns
(PAMPs)
danger-associated
(DAMPs),
non-canonical
recently
only
lipopolysaccharide
(LPS).
Although
larger
number
studies
have
successfully
demonstrated
particularly
the
NLRP3
inflammasome,
play
roles
various
rheumatic
diseases,
including
rheumatoid
arthritis
(RA),
infectious
(IR),
gouty
(GA),
osteoarthritis
(OA),
systemic
lupus
erythematosus
(SLE),
psoriatic
(PA),
ankylosing
spondylitis
(AS),
Sjögren’s
syndrome
(SjS),
regulatory
such
as
mouse
caspase-11
human
caspase-4
these
diseases
still
largely
unknown.
Interestingly,
an
increasing
reported
possible
for
inflammasomes
pathogenesis
models
disease.
This
review
comprehensively
summarizes
discusses
recent
emerging
demonstrating
focusing
on
progression
types
provides
new
insights
into
strategies
developing
potential
therapeutics
prevent
treat
well
associated
by
targeting
inflammasomes.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(10), P. 1923 - 1923
Published: Sept. 28, 2022
Maltol
(3-hydroxy-2-methyl-4-pyrone)
is
used
widely
as
a
food
and
cosmetic
supplement,
it
has
antioxidant
anti-inflammatory
activities.
Inflammasome
causes
the
maturation
secretion
of
interleukin
(IL)-1β
-18
through
activation
caspase-1
(Casp1),
which
contributes
to
various
inflammatory
diseases.
This
study
examined
effects
maltol
on
inflammasome
in
macrophages
mice.
Lipopolysaccharide
(LPS)-primed
were
treated
with
trigger
NLRP3,
NLRC4,
AIM2,
or
non-canonical
(NC)
inflammasomes
presence
maltol.
The
IL-1β
IL-18
cleavage
Casp1
analyzed
indices
activation.
Mice
injected
LPS
an
NLRP3
without
maltol,
peritoneal
secretions
observed.
reactive
oxygen
species
(ROS)
production
activity
determine
mechanism.
inhibited
NC
inflammasomes,
but
did
not
alter
other
inflammasomes.
also
attenuated
resulting
from
mechanism
was
revealed
by
inhibition
ROS
activity.
suggested
be
promising
anti-inflammasome
molecule.
Journal of Ginseng Research,
Journal Year:
2022,
Volume and Issue:
46(3), P. 331 - 336
Published: Feb. 17, 2022
Coronavirus
disease
2019
(COVID-19)
exhibits
various
symptoms,
ranging
from
asymptomatic
to
severe
pneumonia
or
death.
The
major
features
of
patients
in
COVID-19
are
the
dysregulation
cytokine
secretion,
pneumonia,
and
acute
lung
injury.
Consequently,
it
leads
respiratory
distress
syndrome,
disseminated
intravascular
coagulation,
multiple
organ
failure,
Severe
syndrome
coronavirus
2
(SARS-CoV-2),
causative
virus
COVID-19,
influences
nucleotide-binding
oligomerization
domain,
leucine-rich
repeat,
pyrin
domain
containing
3
(NLRP3),
sensor
inflammasomes,
directly
indirectly,
culminating
assembly
NLRP3
inflammasome
activation
inflammatory
caspases,
which
induce
disruption
COVID-19.
Accordingly,
target
therapeutics
for
has
attracted
attention
as
a
treatment
Korean
Red
Ginseng
(KRG)
inhibits
several
responses,
including
signaling.
This
review
discusses
role
KRG
prevention
based
on
its
anti-NLRP3
efficacy.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 4986 - 4986
Published: April 30, 2022
An
inflammatory
response
consists
of
two
consecutive
steps:
priming
and
triggering,
to
prepare
activate
responses,
respectively.
The
cardinal
feature
the
triggering
step
is
activation
intracellular
protein
complexes
called
inflammasomes,
which
provide
a
platform
for
signaling
pathways.
Despite
many
studies
demonstrating
regulatory
roles
canonical
inflammasomes
in
liver
diseases,
newly
discovered
non-canonical
diseases
are
still
largely
unknown.
Recent
have
reported
caspase-11
inflammasome
providing
strong
evidence
that
may
play
key
pathogenesis
diseases.
This
review
comprehensively
discusses
emerging
focusing
on
non-alcoholic
fatty
disease
(NAFLD),
steatohepatitis
(NASH),
injuries
its
underlying
mechanisms.
highlights
current
knowledge
new
insights
into
development
potential
therapeutics
prevent
treat
by
targeting
inflammasome.
