Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 13, 2024
The
emerging
extracellular
vesicles
technologies
is
an
advanced
therapeutic
approach
showing
promising
potential
for
addressing
inflammatory
diseases.
These
techniques
have
been
proven
to
positive
effects
on
immune
modulation
and
anti-inflammatory
responses.
With
these
advancements,
a
comprehensive
review
update
the
role
of
in
diseases
become
timely.
This
aims
summarize
research
progress
vesicle
such
as
plant-derived
vesicles,
milk-derived
mesenchymal
stem
cell-derived
macrophage-derived
etc.,
treatment
It
elucidates
their
significance
regulating
inflammation,
promoting
tissue
repair,
treating
goal
provide
insights
future
this
field,
fostering
application
development
technology
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 19, 2022
Panax
ginseng
C.A.
Mey.
has
a
history
of
more
than
4000
years
and
is
widely
used
in
Asian
countries.
Modern
pharmacological
studies
have
proved
that
ginsenosides
their
compounds
variety
significant
biological
activities
on
specific
diseases,
including
neurodegenerative
certain
types
cancer,
gastrointestinal
disease,
metabolic
which
most
the
interest
focused
ginsenoside
Rd.
The
evidentiary
basis
showed
Rd
ameliorates
ischemic
stroke,
nerve
injury,
other
diseases
involved
apoptosis,
inflammation,
oxidative
stress,
mitochondrial
damage,
autophagy.
In
this
review,
we
summarized
available
reports
molecular
mechanisms
neurological
diseases.
We
also
discussed
main
biotransformation
pathways
obtained
by
fermentation.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
163, P. 114870 - 114870
Published: May 15, 2023
Ginsenosides
are
the
major
and
key
components
for
ginseng
to
exert
its
wide
beneficial
therapeutic
efficacy
in
clinic.
Meanwhile,
many
ginsenosides
their
metabolites
showed
vitro
an
vivo
anti-tumor
activity,
among
which
ginsenoside
Rb1
has
attracted
much
attention
due
good
solubility
amphipathy.
In
this
study,
self-assembly
behavior
of
was
investigated
nano-assembly
could
further
stabilize
or
encapsulated
hydrophobic
drugs
such
as
protopanaxadiol
(PPD)
paclitaxel
(PTX)
form
nanoparticles,
based
on
which,
a
natural
nanoscale
drug
delivery
system,
stabilized
PTX/PPD
co-loaded
nanoparticles
(GPP
NPs)
were
prepared.
The
resultant
GPP
NPs
exhibited
small
particle
size
126.2
nm,
narrow
distribution
(PDI=0.145),
zeta
potential
-27.3
mV.
PTX
loading
content
11.06%
with
encapsulation
efficiency
93.86%.
spherical
stable
normal
saline,
5%
glucose,
PBS,
plasma,
on-shelf
storage
7
days.
Both
PPD
existed
amorphous
state
released
sustained
pattern.
10-fold
higher
activity
than
injections.
experiment,
achieved
tumor
inhibition
rate
injections
(64.95%
vs
43.17%,
P
<
0.01)
certain
target
ability.
conclusion,
had
significantly
enhanced
improved
microenvironment,
thus
promising
be
developed
into
novel
agent
treatment
breast
tumor.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10402 - 10402
Published: June 20, 2023
Inflammasomes
are
multiprotein
complexes
that
activate
inflammatory
responses
by
inducing
pyroptosis
and
secretion
of
pro-inflammatory
cytokines.
Along
with
many
previous
studies
on
diseases
induced
canonical
inflammasomes,
an
increasing
number
have
demonstrated
non-canonical
such
as
mouse
caspase-11
human
caspase-4
emerging
key
players
in
various
diseases.
Flavonoids
natural
bioactive
compounds
found
plants,
fruits,
vegetables,
teas
pharmacological
properties
a
wide
range
Many
successfully
flavonoids
play
anti-inflammatory
role
ameliorate
inhibiting
inflammasomes.
Others
the
roles
diseases,
new
mechanism
which
inhibit
This
review
discusses
recent
investigated
inflammasomes
further
provides
insight
into
developing
flavonoid-based
therapeutics
potential
nutraceuticals
against
Journal of Ginseng Research,
Journal Year:
2023,
Volume and Issue:
48(2), P. 122 - 128
Published: Nov. 14, 2023
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
chronic
characterized
by
hepatic
fat
accumulation,
while
nonalcoholic
steatohepatitis
(NASH)
an
advanced
form
of
NAFLD
inflammation,
fibrosis,
and
injury,
resulting
in
cirrhosis
hepatocellular
carcinoma
(HCC).
Given
the
evidence
that
ginseng
its
major
bioactive
components,
ginsenosides,
have
potent
anti-adipogenic,
anti-inflammatory,
anti-oxidative,
anti-fibrogenic
effects,
pharmacological
effect
ginsenosides
on
NASH
noteworthy.
Furthermore,
numerous
studies
successfully
demonstrated
protective
these
diseases,
as
well
underlying
mechanisms
animal
models
cells,
such
hepatocytes
macrophages.
This
review
discusses
recent
explore
roles
highlights
their
potential
agents
to
prevent
treat
NAFLD,
NASH,
diseases
caused
steatosis
inflammation.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 13, 2024
The
emerging
extracellular
vesicles
technologies
is
an
advanced
therapeutic
approach
showing
promising
potential
for
addressing
inflammatory
diseases.
These
techniques
have
been
proven
to
positive
effects
on
immune
modulation
and
anti-inflammatory
responses.
With
these
advancements,
a
comprehensive
review
update
the
role
of
in
diseases
become
timely.
This
aims
summarize
research
progress
vesicle
such
as
plant-derived
vesicles,
milk-derived
mesenchymal
stem
cell-derived
macrophage-derived
etc.,
treatment
It
elucidates
their
significance
regulating
inflammation,
promoting
tissue
repair,
treating
goal
provide
insights
future
this
field,
fostering
application
development
technology
