Therapeutic Potential of Shilong Qingxue Granule and Its Extract Against Glutamate Induced Neural Injury: Insights from In Vivo and In Vitro Models

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119396 - 119396

Published: Jan. 1, 2025

Language: Английский

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Metabolites from scutellarin alleviating deferoxamine-induced hypoxia injury in BV2 cells cultured on microfluidic chip combined with a mass spectrometer

Talanta, Journal Year: 2023, Volume and Issue: 259, P. 124478 - 124478

Published: March 23, 2023

Language: Английский

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Erigeron breviscapus (Vant.) Hand-Mazz.: A Promising Natural Neuroprotective Agent for Alzheimer’s Disease

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: April 26, 2022

Alzheimer's disease (AD) is the most common neurodegenerative and characterized by progressive cognitive dysfunction memory loss in elderly, which seriously affects quality of their lives. Currently, pathogenesis AD remains unclear. Molecular biologists have proposed a variety hypotheses, including amyloid-β hypothesis, tau hyperphosphorylation cholinergic neuron injury, inflammation caused an abnormal immune response, gene mutation. Drugs based on these pathological studies, cholinesterase inhibitors N-methyl-D-aspartate receptor antagonists, achieved certain level efficacy but are far from meeting clinical needs. In recent years, some important advances been made traditional Chinese medicine treatment AD. Erigeron breviscapus (Vant.) Hand-Mazz. (EBHM) medicinal plant distributed Yunnan Province, China. Studies shown that EBHM its active ingredients pharmacological effects with good therapeutic wide application prospects for disability-related diseases. However, to our best knowledge, only few review articles published anti-AD EBHM. Through literature review, we identified possible AD, discussed cultivation phytochemistry EBHM, summarized mechanism provide suggestions regarding therapy as well broader insight into potential

Language: Английский

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Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia‐reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(8)

Published: Aug. 1, 2024

Cerebral ischemia-reperfusion injury (CIRI) is a common and debilitating complication of cerebrovascular diseases such as stroke, characterized by mitochondrial dysfunction cell apoptosis. Unraveling the molecular mechanisms behind these processes essential for developing effective CIRI treatments. This study investigates role RACK1 (receptor activated C kinase 1) in its impact on autophagy.

Language: Английский

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Naoxintong capsule accelerates mitophagy in cerebral ischemia-reperfusion injury via TP53/PINK1/PRKN pathway based on network pharmacology analysis and experimental validation

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118721 - 118721

Published: Aug. 22, 2024

Language: Английский

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