Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1845 - 1845

Published: Feb. 15, 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical medicinal sections to promote human health prevent cure different diseases. The most common found nature anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, other sub-classes. impacts of plant phenolics on promoting diseases curing preventing antioxidant effects, antibacterial impacts, cardioprotective anticancer immune system promoting, anti-inflammatory skin protective effects from UV radiation. This work aims provide an overview phenolic as important sources medical application according recently published studies, well some interesting directions future research. keyword searches flavonoids, phenolics, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, secoiridoids were performed by using Web Science, Scopus, Google scholar, PubMed. acids contain a carboxylic acid group addition the basic structure mainly divided into hydroxybenzoic hydroxycinnamic acids. Hydroxybenzoic based C6-C1 skeleton often bound small organic acids, glycosyl moieties, or cell structural components. Common include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, salicylic Hydroxycinnamic C6-C3 also molecules such quinic glucose. main caffeic, p-coumaric, ferulic, sinapic

Language: Английский

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Exploration of natural products for the development of promising Cholinesterase inhibitors in Alzheimer’s disease treatment

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42479 - e42479

Published: Feb. 1, 2025

Cholinesterase enzymes (BuChE and AChE) are privileged biological targets for the symptomatic treatment of Alzheimer's disease. Indeed, inhibition cholinesterase has been proven to improve neurotransmission mechanisms in disease patients. In this investigation, we attempt highlight new inhibitors from natural products. For purpose, secondary metabolites (299 phytoconstituents) twenty-eight Medicinal plants were virtually screened using molecular docking, pharmacokinetic toxicological analysis. Ten phytoconstituents (L82, L86, L92, L121, L148, L187, L211, L221, L228) exhibited their high binding affinity with BuChE, five phytoconstituents, namely L119, L147, L149, L192 L193, strong ability AChE. Subsequently, these evaluated ADMET properties. As result, L221 is predicted be highly bioavailable readily absorbed by human intestinal tract without significant toxicity concerns, making it suitable oral administration. Crucially, can penetrate blood-brain barrier (BBB), allowing effectively reach central nervous system. Molecular dynamics simulations MM-PBSA analysis revealed that best-screened phytoconstituent form thermodynamically favorable stable complex BuChE site. The conducted investigations highlighted promising outcomes orient towards rational development effective inhibitors.

Language: Английский

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Acid assisted-hydrothermal carbonization of solid waste from essential oils industry: Optimization using I-optimal experimental design and removal dye application

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(8), P. 104872 - 104872

Published: April 1, 2023

Solid waste (SW) generated from extracting of essential oils medicinal and aromatic plants (MAPs) is an abundant renewable resource, but proper recycling necessary to prevent negative environmental impacts improper disposal. This study focused on converting SW oil (EO) extraction industry by citric acid-catalyzed hydrothermal carbonization (c-HTC) coupled with chemical activation into a carbonaceous material remove organic pollutants. For this purpose, I-optimal design response surface methodology (RSM) was developed investigate the relationship between severity factor (SF) c-HTC process acid dose (HTCcat) carbon retention rate (CRR) hydrochar mass yield (MY). Under optimal conditions (5.32 2 g for SF HTCcat, respectively), optimized (HCop) characterized CRR MY 71.02% 56.14%, respectively. HCop chemically activated KOH solution (AHCop) specific area 989.81 m2.g−1, pore volume 0.583 cm3.g−1, higher heating value (HHV) 37.3 MJ/Kg, oxygenated functions such as –OH, –COOH, C-O methylene blue (MB) removal 90.71%. In addition, modelling adsorption isotherms found that Freundlich isotherm better describes experimental data, second-order model regulates kinetics well. Furthermore, The maximum capacity AHCop 588.24 mg.g−1, separation 0.625 under operating (t = 6 h, T 25 °C, m(AHCop) 0.2 g, [MB]0 300 mg.L-1, pH 7), indicating its potential effectively removing Together, these results provide crucial information using convert biomass functional materials pollutants efficiently. Therefore, several studies must be conducted out discover other application fields material.

Language: Английский

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Planta Medica

Planta Medica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Treatise on Febrile Diseases" refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species [7], and a Latin textbook from roman naturalist Pliny Elder (Gaius Plinius Secundus, AD 23-79) underlined use as follows: "it is given black austere wine, crushed, for coughs, sighs, convulsions, drinking" [8].For decades, have provided herbal remedies treat human diseases [9,10].These medicinal

Language: Английский

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Phlomis crinita Cav. From Algeria: A source of bioactive compounds possessing antioxidant and wound healing activities

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118295 - 118295

Published: May 4, 2024

Phlomis crinita Cav. (Lamiaceae), locally known as "El Khayata" or "Kayat El Adjarah", is traditionally used in Algeria for its wound-healing properties. Investigate, the first time, phytochemical profile, safety, antioxidant and activities of flowering tops methanolic extract P. (PCME) collected from Bouira Province North Algeria. Preliminary assays were carried out on PCME to quantify main classes bioactive compounds, such total phenols, flavonoids, tannins. An in-depth LC-DAD-ESI-MS analysis was elucidate profile this plant species. Antioxidant activity investigated by several colorimetric fluorimetric (DPPH, TEAC, FRAP, ORAC, β-carotene bleaching ferrozine assay). The acute oral toxicity (2000 mg/kg b.w.) tested vivo Swiss albino mice, whereas dermal properties ointment (1-5% PCMO) Wistar rats. Biochemical histological analyses biological samples. screening highlighted a high content phenolic compounds (175.49 ± 0.8 mg gallic acid equivalents/g dry extract), mainly flavonoids (82.28 0.44 quercetin extract). Fifty-seven identified analysis, belonging class flavones (32.27%), with luteolin 7-(6''-acetylglucoside) most abundant compound acids (32.54%), salvianolic C compound. A conspicuous presence phenylethanoids (15.26%) also found, which major constituent forsythoside B. showed strong half-inhibitory (IC50) ranging 1.88 37.88 μg/mL moderate iron chelating (IC50 327.44 μg/mL). appears be safe Lethal Dose 50 (LD50) ≥ 2000 b.w. No mortality signs, including any statistically significant changes body weight gain relative organs' respect control group, recorded. (p < 0.001) wound contraction observed 5% PCMO-treated group untreated petroleum jelly groups between 8 20 days, no results at two lower doses (1 2% PCMO). In addition, 0.05) healing reference drug-treated showing, end study, highest percentage (88.00 0.16%). properties, suggesting new interesting pharmaceutical applications based traditional use.

Language: Английский

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Study on medicinal food plants in the Gaoligongshan Biosphere Reserve, the richest biocultural diversity center in China

Journal of Ethnobiology and Ethnomedicine, Journal Year: 2024, Volume and Issue: 20(1)

Published: Jan. 15, 2024

Abstract Background Traditional knowledge associated with medicinal food plants (MFPs) plays a vital role in fighting hidden hunger and safeguarding the health of local people. MFPs resources are abundant Gaoligongshan area, biosphere reserve richest biocultural diversity China. Local people different linguistic groups also have rich traditional botanical knowledge. However, there still few comprehensive systematic studies on there. Methods Ethnobotanical investigation including market survey, semi-structured interviews, free listing key informant interviews was conducted Western Yunnan, Southwest A total 13 farmers’ markets were selected information about plants, categories, edible parts, modes consumption, effects, distribution collected. The relative occurrence frequency (RFO) cultural significance index (CFSI) calculated to identify culturally significant MFPs. Results 184 species MFPs, belonging 83 families, collected vegetables (77), diets (26), fruits (25), spices (18), herbal tea (13), substitutes (11), for staple (8), nuts (5), oils fats (4), dye material (1). most frequently used families Fabaceae, Asteraceae Apiaceae, 11, 10, 9 species, respectively. plant parts stems, followed by leaves. Based evaluation results CFSI RFO indices, 18 magnificent importance been screened out, such as Houttuynia cordata , Eryngium foetidum Sechium edule Centella asiatica Pseudocydonia sinensis . Conclusion These findings guiding conservation facilitation scientific utilization meet people’s needs healthy life.

Language: Английский

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Acute Oral Toxicity and Neurobehavioral Effects of Salvia officinalis Essential Oil in Female Wistar Rats

Advances in Animal and Veterinary Sciences, Journal Year: 2023, Volume and Issue: 11(4)

Published: Jan. 1, 2023

In recent years, Salvia officinalis has been a subject of intensive studies to document its traditional use and find new biological effects.Numerous have carried out in this contest most them were interested extract' effects not many explored the activities essential oil, especially ones related central nervous system.The Purpose study is investigate acute toxicity salvia oil female Wistar rats, explore antidepressant-like anxiolytic-like memory enhancing safe dose oil.In experiment, was administered once by oral gavage four groups rats (n=6) at three different doses; 1000, 2000 3000 mg/kg.During 14 days after dosing, follow-up for mortality, food water consumption, body weight changing clinical signs.Biochemical parameters organ also examined.The behavior evaluated end experiment anxiety-like depression-like memory.Accordingly, treatment with mg/kg showed no mortality or signs, nor any changes body, weights biochemical parameters, except induced one rat treated mg/kg.Furthermore, LD50 (50% lethal dose) determined mg/kg.Based on these findings, observed adverse effect level established be 1000 mg/kg.Evaluation therapeutic revealed clear anxiolytic antidepressant actions improved functioning rats.In conclusion, produce neuroprotective activity rats.

Language: Английский

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REVISÃO DE ESPÉCIES DA ORDEM CARYOPHYLLALES INVASORAS DOS CANTEIROS DO HORTO DE PLANTAS MEDICINAIS DA UFLA, LAVRAS, MG

Journal of Education Science and Health, Journal Year: 2025, Volume and Issue: 5(1), P. 1 - 11

Published: Feb. 15, 2025

Baccharis L. é um gênero de plantas da família Asteraceae, comum no Brasil, especialmente nas regiões Sul, Sudeste e Centro-Oeste. As desse se adaptam a diferentes ambientes podem variar arbustos árvores pequeno porte. São valorizadas por suas variadas propriedades medicinais. No entanto, apenas cerca 15% das espécies foram analisadas do ponto vista fitoquímico. também tem papel econômico significativo, contribuindo para prevenção erosão sendo como ornamentais. A pesquisa científica revelado potencial significativo aplicações farmacêuticas algumas Baccharis, aumentando o interesse este campo medicina saúde. Este trabalho visou realizar levantamento na região Serra Carrancas, em Minas Gerais. Onde identificadas 13 distintas pertencentes ao logo após foi feita validação dos binômios botânicos seus respectivos autores. Com essas realizamos bibliográfico registros etnobotânicos farmacológicos.

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ETHNO- MEDICINAL PLANTS USED FOR SKIN CARE IN SIRMOUR DISTRICT OF HIMACHAL PRADESH (INDIA)

Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101004 - 101004

Published: Feb. 1, 2025

Language: Английский

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Lavandula dentata leaves as potential natural antibiofilm agents against Pseudomonas aeruginosa

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

Abstract Biofilm formation is responsible for persistent diseases related to chronic infections. Mostly it triggered by many bacteria, mainly Pseudomonas aeruginosa ( P. ). In this study, plants that have been used traditionally in skin infections Viz; Liquorice, Carrot, Red Cabbage, Beetroot, Turmeric, Neem, and French Lavender were selected evaluate their antibiofilm activity against . The microtiter plate assay was as well ability reduce the of To investigate phytocompounds bioactivity superior extract explore potential interactions between its bioactive components one quorum-sensing (QS) regulatory proteins involved biofilm formation, liquid chromatography-mass spectrometric (LC-MS) molecular docking studies done. study showed all tested plant extracts could significantly p -value < 0.05) biofilm. methanol Lavandula dentata L. ) leaves at 0.625 mg/mL. conclusion, revealed presence phenolic acids, flavonoids, glycosides also, anti- reported herein first time be a good source leads medicine.

Language: Английский

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