Heliyon,
Journal Year:
2023,
Volume and Issue:
10(1), P. e23581 - e23581
Published: Dec. 11, 2023
Sinomenine
(SN)
is
a
well-documented
unique
plant
alkaloid
extracted
from
many
herbal
medicines.
The
present
study
evaluates
the
wound
healing
potentials
of
SN
on
dorsal
neck
injury
in
rats.
A
uniform
cut
was
created
Sprague
Dawley
rats
(24)
which
were
arbitrarily
aligned
into
4
groups
receiving
two
daily
topical
treatments
for
14
days
as
follows:
A,
had
gum
acacia;
B,
addressed
with
intrasite
gel;
C
and
D,
30
60
mg/ml
SN,
respectively.
acute
toxicity
trial
revealed
absence
any
toxic
signs
after
weeks
ingestion
300
mg/kg
SN.
SN-treated
showed
smaller
areas
higher
closure
percentages
compared
to
vehicle
5,
10,
15
skin
excision.
Histological
evaluation
recovered
tissues
increased
collagen
deposition,
fibroblast
content,
decreased
inflammatory
cells
granulated
SN-addressed
rats,
statistically
different
that
acacia-treated
treatment
caused
positive
augmentation
Transforming
Growth
Factor
Beta
1
(angiogenetic
factor)
tissues,
denoting
conversion
rate
myofibroblast
(angiogenesis)
results
faster
action.
Increased
antioxidant
enzymes
(SOD
CAT),
well
MDA
contents
suggest
aid
recovery.
Wound
tissue
homogenates
hydroxyproline
amino
acid
(collagen
content)
values
than
suppressed
production
pro-inflammatory
cytokines
anti-inflammatory
serum
wounded
outcomes
viable
pharmaceutical
agent
evidenced
by
its
modulation
antioxidant,
immunohistochemically
proteins,
hydroxyproline,
cytokines.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(3), P. 347 - 347
Published: Feb. 24, 2023
Skin
tissue
has
a
crucial
role
in
protecting
the
human
body
from
external
harmful
agents,
preventing
wounds
that
frequently
demand
proper
healing
approaches.
The
ethnobotanical
knowledge
of
specific
regions
with
further
investigation
on
their
medicinal
plants
been
paramount
to
create
new
and
effective
therapeutical
including
for
dermatological
purposes.
This
review
attempts,
first
time,
investigate
traditional
applications
Lamiaceae
are
already
used
by
local
communities
Iberian
Peninsula
wound
healing.
Henceforward,
surveys
were
reviewed,
information
about
practices
was
comprehensively
summarized.
Afterwards,
scientific
validation
each
species
exhaustively
checked.
From
this,
eight
out
twenty-nine
highlighted
wound-related
pharmacological
evidence
in-depth
presented
this
review.
We
suggest
future
studies
should
focus
isolation
identification
active
molecules
these
Lamiaceae,
followed
robust
clinical
trials
may
confirm
security
effectiveness
such
natural-based
will
turn
pave
way
more
reliable
treatments.
Heliyon,
Journal Year:
2023,
Volume and Issue:
10(1), P. e23581 - e23581
Published: Dec. 11, 2023
Sinomenine
(SN)
is
a
well-documented
unique
plant
alkaloid
extracted
from
many
herbal
medicines.
The
present
study
evaluates
the
wound
healing
potentials
of
SN
on
dorsal
neck
injury
in
rats.
A
uniform
cut
was
created
Sprague
Dawley
rats
(24)
which
were
arbitrarily
aligned
into
4
groups
receiving
two
daily
topical
treatments
for
14
days
as
follows:
A,
had
gum
acacia;
B,
addressed
with
intrasite
gel;
C
and
D,
30
60
mg/ml
SN,
respectively.
acute
toxicity
trial
revealed
absence
any
toxic
signs
after
weeks
ingestion
300
mg/kg
SN.
SN-treated
showed
smaller
areas
higher
closure
percentages
compared
to
vehicle
5,
10,
15
skin
excision.
Histological
evaluation
recovered
tissues
increased
collagen
deposition,
fibroblast
content,
decreased
inflammatory
cells
granulated
SN-addressed
rats,
statistically
different
that
acacia-treated
treatment
caused
positive
augmentation
Transforming
Growth
Factor
Beta
1
(angiogenetic
factor)
tissues,
denoting
conversion
rate
myofibroblast
(angiogenesis)
results
faster
action.
Increased
antioxidant
enzymes
(SOD
CAT),
well
MDA
contents
suggest
aid
recovery.
Wound
tissue
homogenates
hydroxyproline
amino
acid
(collagen
content)
values
than
suppressed
production
pro-inflammatory
cytokines
anti-inflammatory
serum
wounded
outcomes
viable
pharmaceutical
agent
evidenced
by
its
modulation
antioxidant,
immunohistochemically
proteins,
hydroxyproline,
cytokines.
