International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 16093 - 16093
Published: Dec. 17, 2022
Remyelination
therapies,
which
are
currently
under
development,
have
a
great
potential
to
delay,
prevent
or
even
reverse
disability
in
multiple
sclerosis
patients.
Several
models
available
study
the
effectiveness
of
novel
compounds
vivo,
among
is
cuprizone
model.
This
model
characterized
by
toxin-induced
demyelination,
followed
endogenous
remyelination
after
cessation
intoxication.
Due
its
high
reproducibility
and
ease
use,
this
enjoys
popularity
various
research
industrial
groups.
In
review
article,
we
will
summarize
recent
findings
using
discuss
some
identified
promote
Frontiers in Molecular Neuroscience,
Journal Year:
2023,
Volume and Issue:
16
Published: March 16, 2023
Research
has
long
centered
on
the
pathophysiology
of
pain.
The
Transient
Receiver
Potential
(TRP)
protein
family
is
well
known
for
its
function
in
pain,
and
extensive
study
been
done
this
area.
One
significant
mechanisms
pain
etiology
analgesia
that
lacks
a
systematic
synthesis
review
ERK/CREB
(Extracellular
Signal-Regulated
Kinase/CAMP
Response
Element
Binding
Protein)
pathway.
pathway-targeting
analgesics
may
also
cause
variety
adverse
effects
call
specialized
medical
care.
In
review,
we
systematically
compiled
mechanism
pathway
process
analgesia,
as
potential
nervous
system
brought
by
inhibition
analgesic
drugs,
suggested
corresponding
solutions.
Neuroscience,
Journal Year:
2023,
Volume and Issue:
538, P. 1 - 10
Published: Oct. 31, 2023
With
the
deepening
of
population
aging,
treatment
cognitive
impairment
and
dementia
is
facing
increasing
challenges.
Vascular
(VaD)
a
dysfunction
caused
by
brain
blood
flow
damage
one
most
common
causes
after
Alzheimer's
disease.
White
matter
in
patients
with
chronic
ischemic
often
occurs
before
impairment,
its
pathological
changes
include
leukoaraiosis,
myelin
destruction
oligodendrocyte
death.
The
pathophysiology
vascular
complex,
involving
variety
neuronal
lesions.
current
proposed
mechanisms
calcium
overload,
oxidative
stress,
nitrative
stress
inflammatory
damage,
which
can
lead
to
hypoxia-ischemia
demyelination.
Oligodendrocytes
are
only
myelinating
cells
central
nervous
system
closely
associated
VaD.
In
this
review
article,
we
intend
further
discuss
role
oligodendrocytes
white
injury
VaD
development
anti-myelin
target
drugs.
