Essential Oils: Chemistry and Pharmacological Activities

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1144 - 1144

Published: July 18, 2023

In this review, we provide an overview of the current understanding main mechanisms pharmacological action essential oils and their components in various biological systems. A brief introduction on oil chemistry is presented to better understand relationship chemical aspects with bioactivity these products. Next, antioxidant, anti-inflammatory, antitumor, antimicrobial activities are discussed. The against types viruses also addressed. data show that multiplicity properties occurs due diversity composition ability interfere processes at cellular multicellular levels via interaction targets. Therefore, natural products can be a promising source for development new drugs.

Language: Английский

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Essential oils pharmacological activity: Chemical markers, biogenesis, plant sources, and commercial products

Process Biochemistry, Journal Year: 2024, Volume and Issue: 144, P. 112 - 132

Published: May 24, 2024

Language: Английский

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Antioxidant Activity of Essential Oils from Pinaceae Species

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 286 - 286

Published: Feb. 26, 2024

With a widespread distribution throughout the Northern Hemisphere and 11 genera, Pinaceae is largest family of

Language: Английский

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Effects of microbial fermentation on the anti-inflammatory activity of Chinese yam polysaccharides

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

In this study, Chinese yam polysaccharides (CYPs) were fermented using Lactobacillus plantarum M616, and changes in the chemical composition, structure, anti-inflammatory activity of CYPs before after fermentation investigated. The carbohydrate content L. M616-fermented CYP (CYP-LP) increased from 71.03% ± 2.75 to 76.28% 2.37%, whereas protein polyphenol almost unaffected compared with those unfermented (CYP-NF). monosaccharide composition CYP-NF included rhamnose, arabinose, galactose, glucose, mannose a molar ratio 0.493:0.6695:0.9738:0.7655:12.4365. CYP-LP had same monosaccharides as CYP-NF, but was 0.3237:0.3457:0.8278:2.5541:10.4995. Meanwhile, molecular weight polydispersity CYP-LP, respectively, 124.774 kDa 6.58 (CYP-NF) 376.628 17.928, indicating low homogeneity. vitro antioxidant analysis showed that M616 varying effects on against DPPH, ABTS, hydroxyl, superoxide radicals. However, superior is more effective regulating dismutase, catalase, glutathione peroxidase, malondialdehyde, nitric oxide, tumor necrosis factor-α, interleukin-1β, interleukin-6 release lipopolysaccharide-induced RAW 264.7 macrophages. This study suggested potential ingredient drugs functional food.

Language: Английский

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trans-Cinnamaldehyde as a Novel Candidate to Overcome Bacterial Resistance: An Overview of In Vitro Studies

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 254 - 254

Published: Jan. 27, 2023

The increasing of drug-resistant bacteria and the scanty availability novel effective antibacterial agents represent alarming problems modern society, which stimulated researchers to investigate strategies replace or assist synthetic antibiotics. A great deal attention has been devoted over years essential oils that contain mixtures volatile compounds have traditionally exploited as antimicrobial remedies. Among oil phytochemicals, remarkable antibiotic-potentiating activities highlighted for cinnamaldehyde, an α,β-unsaturated aldehyde, particularly abundant in Cinnamomum spp., widely used a food additive industrial products. In line with this evidence, present study, overview available literature carried out order define bacterial sensitizing profile cinnamaldehyde. vitro studies displayed ability substance resensitize microbial strains drugs increase efficacy different antibiotics, especially cefotaxime, ciprofloxacin, gentamicin; however, vivo, clinical trials are lacking. Based on collected findings, cinnamaldehyde appears be interest adjuvant agent overcome superbug infections antibiotic resistance; future more in-dept investigations should encouraged clarify its mechanisms involved.

Language: Английский

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Essential Oils from Apiaceae, Asteraceae, Cupressaceae and Lamiaceae Families Grown in Serbia: Comparative Chemical Profiling with In Vitro Antioxidant Activity

Plants, Journal Year: 2023, Volume and Issue: 12(4), P. 745 - 745

Published: Feb. 7, 2023

The aim of the present study was to investigate chemical profile and antioxidant activity essential oils obtained from most commonly grown plant species in Serbia. Aromatic medicinal plants Lamiaceae (Mentha x Piperita, Ocimum basilicum, Origanum majorana, vulgare, Salvia officinalis, Satureja hortensis, montana Thymus vulgaris), Asteraceae (Ehinacea purpurea Matricaria chamomilla), Apiaceae (Anethum graveolens, Carum carvi, Foeniculum Petroselinum crispum Pimpinella anisum) Cupressaceae (Juniperus comunis) were selected as raw material for (EOs)’ isolation. Hydrodistillation (HD) used isolation EOs while they evaluated terms yield terpenoid profiles by GC-MS. In vitro radical scavenging DPPH ABTS+ activities carried out all EOs. Finally, a principal component analysis (PCA) performed with experimental results composition EOs, which showed clear distinction between aforementioned responses. This work represents screening tool selection other EO candidates further processing emerging extraction techniques use natural additives meat products.

Language: Английский

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Agarwood Oil Nanoemulsion Attenuates Cigarette Smoke-Induced Inflammation and Oxidative Stress Markers in BCi-NS1.1 Airway Epithelial Cells

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1019 - 1019

Published: Feb. 17, 2023

Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory characterized by frequent exacerbations and symptoms such as cough wheezing that lead to airway damage hyperresponsiveness. The primary risk factor for COPD chronic cigarette smoke exposure, which promotes oxidative stress a general pro-inflammatory condition stimulating pro-oxidant pathways and, simultaneously, inactivating anti-inflammatory antioxidant detoxification pathways. These events cause progressive resulting in impaired cell function progression. Treatments available are generally aimed at reducing the of exacerbation. Failure regulate inflammation results lung damage. In quest innovative treatment strategies, phytochemicals, complex plant extracts agarwood essential oil promising sources molecules with activity. However, their clinical use limited issues low solubility poor pharmacokinetic properties. can be overcome encapsulating therapeutic using advanced drug delivery systems polymeric nanosystems nanoemulsions. this study, nanoemulsion (agarwood-NE) was formulated tested its potential extract (CSE)-treated BCi-NS1.1 basal epithelial cells. findings suggest successful counteractivity agarwood-NE against CSE-mediated effects expression cytokines IL-1α, IL-1β, IL-8, GDF-15. addition, induced mediators IL-10, IL-18BP, TFF3, GH, VDBP, relaxin-2, IFN-γ, PDGF. Furthermore, also genes GCLC GSTP1, simultaneously activating PI3K pro-survival signalling pathway. This study provides proof dual activity agarwood-NE, highlighting enormous treatment.

Language: Английский

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Potentialities of Monodora myristica active components as functional ingredients in food formulation

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100884 - 100884

Published: Jan. 5, 2025

Language: Английский

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Integrating network pharmacology and experimental verification to decipher the multitarget pharmacological mechanism of Cinnamomum zeylanicum essential oil in treating inflammation

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24120 - e24120

Published: Jan. 1, 2024

Inflammatory diseases contribute to more than 50 % of global deaths. Research suggests that network pharmacology can reveal the biological mechanisms underlying inflammatory and drug effects at molecular level. The aim study was clarify mechanism

Language: Английский

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In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 409 - 409

Published: March 23, 2024

Sambucus nigra L. (S. nigra, SN) or black elder is a traditional medicinal plant widely used worldwide for therapeutic and dietary purposes. The aim of the current study was to investigate anti-inflammatory antinociceptive activities fruit flower extracts (SNFrE SNFlE, respectively). primary polyphenol constituents in extract were flavonoids phenolic acids, while anthocyanins main components extract. SNFrE revealed pronounced dose-dependent vivo activity assessed by cotton pellet-induced granuloma test. Doses 10, 20, 50 mg/kg BW reduced weight induced rats 20.3%, 20.5%, 28.4%, respectively. At highest dose (50 BW), had significant (p < 0.01) comparable that diclofenac, reference compound (10 BW). In addition, mice estimated using acetic-acid-induced writhing Both at doses inhibited abdominal contractions acetic acid significantly comparing control group 0.01). Our findings indicate particularly possess activities, providing experimental evidence use S. medicine.

Language: Английский

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