Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations

Natural Products and Bioprospecting, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 30, 2024

Abstract Ulcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining of lower part large intestine. Conventional treatment options such as salicylates, corticosteroids, and immunosuppressants often come with severe side effects, limited bioavailability, development drug resistance, which hampers their therapeutic effectiveness. Therefore, it imperative to explore natural strategies safe alternative treatments for UC. Currently, around 40% UC patients find relief through constituents, can help reduce toxic effects maintain clinical remission. This review aims provide summary both preclinical evidence supporting efficacy various substances prophylaxis These include plant extracts, essential oils, nutraceuticals, phytochemicals. Furthermore, we will delve into potential mechanisms that underlie protective curative actions these novel herbal agents. In summary, this effectiveness remedies UC, shedding light on findings behind actions. alternatives offer hope improved outcomes reduced individuals suffering from challenging condition. Graphical

Language: Английский

---

Evaluation of the synergistic antifungal effects of thymol and cinnamaldehyde combination and its mechanism of action against Rhizopus stolonifer in vitro and in vivo

Biocatalysis and Agricultural Biotechnology, Journal Year: 2023, Volume and Issue: 49, P. 102658 - 102658

Published: Feb. 20, 2023

Language: Английский

---

Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology Approach

Future Integrative Medicine, Journal Year: 2024, Volume and Issue: 3(2), P. 116 - 131

Published: May 15, 2024

Essential oils, known for their pleasant aromas, not only calm the mind and elevate mood but also captivate interest of researchers aiming to unveil vast potential. Various methodologies are employed explore diverse capabilities essential often yielding promising significant outcomes. This review aims elucidate molecular mechanisms oils at cellular level. It identifies multiple through which exhibit therapeutic effects across various systems. However, a comprehensive understanding fundamental still necessitates extensive research. In this review, we discuss underlying biological activities specifically antioxidant, antimicrobial, anticarcinogenic, anti-diabetic, anti-inflammatory properties.

Language: Английский

---

Lavanta Yağı ve Genetik Etkileşim: Epigenetik Perspektiften Sağlık Üzerine Bir İnceleme

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, Journal Year: 2025, Volume and Issue: 15(1), P. 69 - 76

Published: Jan. 29, 2025

Amaç: Lavanta yağı, Lamiaceae ailesinin önemli bir üyesi olan lavanta bitkisinden elde edilen ve çeşitli terapötik etkilerle öne çıkan uçucu yağdır. Tarihsel olarak, antik medeniyetlerden günümüze kadar antibakteriyel, antienflamatuar, anksiyolitik, antifungal yara iyileştirici özellikleri nedeniyle geniş kullanım alanı bulmuştur. yağının temel bileşenleri linalool linalil asetat, sinir sistemi üzerinde yatıştırıcı etkiler gösterirken, inflamasyonu oksidatif stresi azaltarak kronik hastalıkların tedavisine yardımcı olabilmektedir. Yapılan araştırmalar, nörolojik bozukluklardan kansere uzanan etki spektrumu olduğunu ortaya koymuş, ancak bu etkilerin moleküler düzeyde nasıl gerçekleştiği henüz tam olarak anlaşılmamıştır. Çalışmanın amacı güncel literatürü mikroRNA’lar çerçevesinde derlemektir. Yöntem: içeriği “Lavanta yağı”, “miRNA”, “epigenetik”, “gen ifadesi” anahtar kelimelerinin kombinasyonları ile PubMed, Google akademik, Web of science Science direct veri tabanlarından yapılan taramalarla oluşturulmuştur. Bulgular: Son yıllarda, esansiyel yağların genetik epigenetik düzeydeki etkileri durulmakta miRNA'lar olası etkileşimleri incelenmektedir. miRNA'ların gen ekspresyonunun düzenlenmesindeki kritik rolü göz önüne alındığında, özellikle stres, depresyon inflamasyonla ilişkili miRNA'ları etkileyerek mekanizmaları modüle etme potansiyeli büyük araştırma karşımıza çıkmaktadır. Ancak, alandaki literatür eksikliği dikkat çekmektedir. etkilerinin daha iyi anlaşılması, üzerindeki etkilerine odaklanan çalışmaların artmasıyla mümkün olacaktır. Sonuç: Gelecekteki çalışmalar, biyolojideki yerini sağlamlaştırabilir klinik kullanımı genişletebilir. Bu doğrultuda, biyolojik mekanizmalarını aydınlatmak, onu tedavisinde etkili araç haline getirebilir.

---

Eucalyptol Attenuates Indomethacin-Induced Gastric Ulcers in Rats by Modulating the ICAM-1, eNOS and COX/LOX Pathways: Insights from In Silico, In Vitro and In Vivo Approaches

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115319 - 115319

Published: Feb. 1, 2025

Language: Английский

---

An in-depth overview of the nutritional advantages of medicinal plant supplementation in poultry feed

World s Poultry Science Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: Feb. 28, 2025

Language: Английский

---

Anti-inflammatory effects of the aged garlic extracts in LPS-stimulated RAW 264.7 cells

Deleted Journal, Journal Year: 2025, Volume and Issue: 32(1), P. 136 - 148

Published: Feb. 1, 2025

The study was to investigate the anti-inflammatory effects of water, 50% ethanol, and 100% ethanol extracts aged garlic on LPS-stimulated RAW 264.7 macrophages. Total polyphenol content determined using a colorimetric assay. Active compounds were quantified HPLC-MS/MS. production nitric oxide (NO) in culture medium through Griess reaction. levels pro-inflammatory cytokines, including IL-1β, IL-6, TNF-α, an ELISA kit. be 356.31±1.74, 334.41±2.27, 2,569.02±21.30 mg/100 g dry basis, respectively. highest contents S-allyl cysteine S-1-propenyl-L-cysteine observed extract, while γ-glutamyl-S-allyl-L-cysteine γ-glutamyl-S-1-propenyl-L-cysteine water extracts, with similar trend except for extract. extract demonstrated significant inhibitory LPS-induced NO at non-cytotoxic concentrations. Additionally, ability inhibit phosphorylation p38 ERK, key signaling molecules implicated inflammatory response, cells. These findings suggest that has potential used as functional food material preventing diseases.

Language: Английский

---

Mesosphaerum suaveolens Essential Oil Attenuates Inflammatory Response and Oxidative Stress in LPS-Stimulated RAW 264.7 Macrophages by Regulating NF-κB Signaling Pathway

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5817 - 5817

Published: Aug. 2, 2023

Mesosphaerum suaveolens (L.) Kuntze (Syn. Hyptis Poit.) is a wild essential-oil-bearing plant having multiple uses in traditional medicine, perfumery, food, agriculture, and pharmaceutical industries. The present paper the first report on vitro anti-inflammatory effects of leaf essential oil M. (MSLEO) unravels its molecular mechanism LPS-stimulated RAW 264.7 macrophage cells. GC-MS analysis (EO) isolated from leaves by hydro-distillation led to identification 48 constituents, accounting for 90.55% total oil, β-caryophyllene (16.17%), phyllocladene (11.85%), abietatriene (11.46%), spathulenol (7.89%) were found be major components. MSLEO treatment had no effect viability cells up concentration 100 μg/mL, EO was responsible reduction proinflammatory cytokines like IL-6, IL-1β, TNF-α, decrease intracellular ROS production, restoration oxidative damage elevating levels endogenous antioxidative enzymes CAT, SOD, GPx, GSH. RT-qPCR indicated that reduced mRNA expression iNOS COX-2 as compared LPS-induced group. In addition, confocal microscopy showed inhibited translocation NF-κB cytosol nucleus. results this experiment demonstrate possesses significant potential preventing activation NF-κB, which, turn, inhibits downstream other inflammatory mediators associated with pathway Thus, may prove promising therapeutic agent inflammation, targeting signaling considered an attractive approach therapies.

Language: Английский

---

Unravelling the Antimicrobial, Antibiofilm, Suppressing Fibronectin Binding Protein A (fnba) and cna Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized Solanum lycopersicum Silver Nanoparticles

Medicina, Journal Year: 2024, Volume and Issue: 60(3), P. 515 - 515

Published: March 21, 2024

Background and Objectives: Urinary tract infections [UTIs] are considered the third most known risk of infection in human health around world. There is increasing appreciation for pathogenicity Gram-positive Gram-negative strains UTIs, aside from fungal infection, as they have numerous virulence factors. Materials Methods: In this study, fifty urine samples were collected patients suffering UTI. Among isolates UTI microbes, six described MDR after an antibiotic susceptibility test carried out using ten different antibiotics. An alternative treatment microbial elimination involved use biosynthesized silver nanoparticles (AgNPs) derived Solanum lycopersicum [S. cumin]. Results: The sizes shapes AgNPs characterized through TEM imaging, which showed spherical particles a size range 35–80 nm, average was 53 nm. Additionally, demonstrated inhibitory activity against Staphylococcus aureus (OR648079), exhibiting 31 mm zone inhibition at minimum concentration (MIC) 4 mg/mL bactericidal (MBC) 8 mg/mL. This followed by Aspergillus niger (OR648075), 30 MIC 16 fungicidal (MFC) 32 Then, Enterococcus faecalis (OR648078), Klebsiella pneumoniae (OR648081), Acinetobacter baumannii (OR648080) each displayed 29 MBC least observed Candida auris (OR648076), with 25 MFC Furthermore, concentrations removed DPPH H2O2 IC50 value 13.54 μg/mL. Also, 3 remarkable DNA fragmentation all bacterial except faecalis. phytochemical analysis presence active organic components plant extract, concluded that rutin 88.3 mg/g, garlic acid 70.4 tannic 23.7 mg/g. Finally, 3–6 decreased expression two fundamental genes necessary biofilm formation within aureus, fnbA (6 folds), Cna (12.5 folds) when compared RecA gene, one-fold control sample. These submitted NCBI accession numbers [OR682119] [OR682118], respectively. Conclusions: findings study indicate exhibit promising antimicrobial antioxidant properties pathogens, including resistant to multiple suggests their potential effective UTIs. Further research warranted fully understand mechanisms action explore therapeutic applications these combating

Language: Английский

---

Coatings Based on Essential Oils for Combating Antibiotic Resistance

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 625 - 625

Published: July 4, 2024

In the current era of widespread antimicrobial resistance, utilization essential oils (EOs) derived from plants has emerged as a promising alternative in combating pathogens that have developed resistance to antibiotics. This review explores therapeutic potential valuable tools restoring efficacy antibiotics, highlighting their unique ability affect bacteria multiple ways and target various cellular systems. Despite challenge elucidating precise mode action, EOs shown remarkable results rigorous testing against diverse range bacteria. multifaceted role bacterial microorganisms, emphasizing extraction methods, mechanisms comparative synthetic Key findings underscore strategies deploy counter bacteria, significant differences conventional The extends advanced coating solutions for medical devices, exploring integration EO formulations into these coatings. Challenges developing effective coatings are addressed, along with innovative approaches implementation. An evaluation reveals formidable alternatives traditional antibacterial agents device applications. renaissance natural remedies emphasizes need combine wisdom modern scientific advancements address urgent post-antibiotic era.

Language: Английский

---