Design, synthesis, and in-Silco ADME prediction of some novel bis(1,3,4-thiadiazoles) encapsulated lipid chitosan nano capsule decorative with magnetic nanoparticles and their potential anti-helicobacter pylori activity

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139746 - 139746

Published: Jan. 1, 2025

Language: Английский

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The effects and mechanisms of natural products on Helicobacter pylori eradication

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 28, 2024

Helicobacter pylori (H. pylori) eradication is pivotal for alleviating gastric mucosal inflammation and preventing the progression of diseases. While antibiotic-based therapies have achieved significant success in H. eradication, challenges such as antibiotic resistance, drug toxicity, side effects, nonadherence, inapplicability, disruption gastrointestinal microflora emerged. Updated are urgently needed to suppress pylori. Nature has provided multitudinous therapeutic agents since ancient times. Natural products can be a potential therapy endowed with efficacy. We summarize basic information, possible mechanisms, latest research progress some representative natural highlighting their safety, accessibility, efficiency, ability overcome limitations associated application. This review highlights advantages incorporating ethnomedicine into anti-H. regimens. The findings this may provide insights development novel expand options available eradication.

Language: Английский

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Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(28), P. 15725 - 15739

Published: July 8, 2024

Indole-3-lactic acid (ILA) has exhibited antimicrobial properties. However, its role in inhibiting

Language: Английский

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Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'

Phytochemistry Letters, Journal Year: 2025, Volume and Issue: 66, P. 77 - 80

Published: Feb. 17, 2025

Language: Английский

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Edible and Herbal Plants against Helicobacter pylori infection: from Epidemiological, Experimental studies to Clinical Perspectives

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 201, P. 107386 - 107386

Published: Feb. 19, 2025

Language: Английский

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A systematic review of the botany, ethnopharmacology, quality control, phytochemistry, pharmacology and pharmacokinetics of Corydalis yanhusuo

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 12, 2025

Pulmonary fibrosis (PF) is an irreversible, progressive, chronic and fatal interstitial lung disease with limited therapeutic options. Dehydrocorydaline (DHC), derived from the traditional Chinese medicinal plant Corydalis yanhusuo, has exhibited a variety of pharmacological properties. Nevertheless, potential function mechanism DHC in management PF have yet to be elucidated. To evaluate therapeutical efficacy different models elucidate its underlying mechanism. A well-established Bleomycin-induced mouse model human precision-cut slices (hPCLS) following fibrosis-inducing cocktail stimulation were employed. The antifibrotic effects on measured by histopathological manifestation, immunofluorescent staining expression levels related markers. Human primary pulmonary fibroblasts (HPFs) used explore impact fibroblast Here, we demonstrated that dose dependent, as well hPCLS after stimulation, evidenced staining, decrease Fibronectin, Collagen 1 α-SMA expression. Additionally, vitro experiments indicated effectively suppressed myofibroblast transition, but had no significant effect proliferation migration fibroblast. Mechanistic studies revealed inhibitory activation was dependent endoplasmic reticulum stress, thereby inhibiting TGF-β/SMAD signal pathway. Our study implied hold promise approach against suppressing activation. safety been preliminary model.

Language: Английский

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Plant-derived extracts or compounds for Helicobacter-associated gastritis: a systematic review of their anti-Helicobacter activity and anti-inflammatory effect in animal experiments

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 22, 2025

Language: Английский

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In vitro anti-Helicobacter pylori, anti-urease and anti-gastric cancer activities of novel hydrazones

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1307, P. 137961 - 137961

Published: March 4, 2024

Language: Английский

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Review of Phytochemical Potency as a Natural Anti-Helicobacter pylori and Neuroprotective Agent

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7150 - 7150

Published: Oct. 18, 2023

Phytochemicals are plant secondary metabolites that show health benefits for humans due to their bioactivity. There is a huge variety of phytochemicals have already been identified, and these compounds can act as antimicrobial neuroprotection agents. Due anti-microbial activity neuroprotection, several might the potency be used natural therapeutic agents, especially Helicobacter pylori infection neurodegenerative disease, which become global concern nowadays. According previous research, there some connections between H. diseases, Alzheimer's disease. Hence, this comprehensive review examines different kinds from sources potential agents reduce improve An additional large-scale study needed establish connection disease how could condition.

Language: Английский

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