Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
15(2), С. 101075 - 101075
Опубликована: Авг. 19, 2024
Gastric
carcinoma
(GC)
is
a
malignancy
with
multifactorial
involvement,
multicellular
regulation,
and
multistage
evolution.
The
classic
Correa's
cascade
of
intestinal
GC
specifies
trilogy
malignant
transformation
the
gastric
mucosa,
in
which
normal
mucosa
gradually
progresses
from
inactive
or
chronic
active
gastritis
(Phase
I)
to
precancerous
lesions
II)
finally
III).
highlights
evolutionary
pattern
importance
early
intervention
prevent
mucosa.
Intervening
mucosal
lesions,
i.e.,
Phase
I
II,
will
be
key
strategy
treat
GC.
Natural
products
(NPs)
have
been
an
important
source
for
drug
development
due
abundant
sources,
tremendous
safety,
multiple
pharmacodynamic
mechanisms.
This
review
first
investigate
summarize
multi-step
effects
regulatory
mechanisms
NPs
on
carcinogenesis.
In
phase
I,
modulate
Helicobacter
pylori
urease
activity,
motility,
adhesion,
virulence
factors,
resistance,
thereby
inhibiting
H.
pylori-induced
inflammation
oxidative
stress,
facilitating
ulcer
healing.
pathways
mediators
regulating
cell
cycle,
apoptosis,
autophagy,
angiogenesis
reverse
lesions.
III,
suppress
proliferation,
migration,
invasion,
angiogenesis,
cancer
stem
cells,
induce
apoptosis
enhance
chemotherapeutic
sensitivity
treatment
contrast
existing
work,
we
hope
uncover
sequential
therapeutic
phases
development,
providing
new
ideas
prevention,
treatment,
development.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 28, 2024
Helicobacter
pylori
(H.
pylori)
eradication
is
pivotal
for
alleviating
gastric
mucosal
inflammation
and
preventing
the
progression
of
diseases.
While
antibiotic-based
therapies
have
achieved
significant
success
in
H.
eradication,
challenges
such
as
antibiotic
resistance,
drug
toxicity,
side
effects,
nonadherence,
inapplicability,
disruption
gastrointestinal
microflora
emerged.
Updated
are
urgently
needed
to
suppress
pylori.
Nature
has
provided
multitudinous
therapeutic
agents
since
ancient
times.
Natural
products
can
be
a
potential
therapy
endowed
with
efficacy.
We
summarize
basic
information,
possible
mechanisms,
latest
research
progress
some
representative
natural
highlighting
their
safety,
accessibility,
efficiency,
ability
overcome
limitations
associated
application.
This
review
highlights
advantages
incorporating
ethnomedicine
into
anti-H.
regimens.
The
findings
this
may
provide
insights
development
novel
expand
options
available
eradication.
Respiratory Research,
Год журнала:
2025,
Номер
26(1)
Опубликована: Апрель 12, 2025
Pulmonary
fibrosis
(PF)
is
an
irreversible,
progressive,
chronic
and
fatal
interstitial
lung
disease
with
limited
therapeutic
options.
Dehydrocorydaline
(DHC),
derived
from
the
traditional
Chinese
medicinal
plant
Corydalis
yanhusuo,
has
exhibited
a
variety
of
pharmacological
properties.
Nevertheless,
potential
function
mechanism
DHC
in
management
PF
have
yet
to
be
elucidated.
To
evaluate
therapeutical
efficacy
different
models
elucidate
its
underlying
mechanism.
A
well-established
Bleomycin-induced
mouse
model
human
precision-cut
slices
(hPCLS)
following
fibrosis-inducing
cocktail
stimulation
were
employed.
The
antifibrotic
effects
on
measured
by
histopathological
manifestation,
immunofluorescent
staining
expression
levels
related
markers.
Human
primary
pulmonary
fibroblasts
(HPFs)
used
explore
impact
fibroblast
Here,
we
demonstrated
that
dose
dependent,
as
well
hPCLS
after
stimulation,
evidenced
staining,
decrease
Fibronectin,
Collagen
1
α-SMA
expression.
Additionally,
vitro
experiments
indicated
effectively
suppressed
myofibroblast
transition,
but
had
no
significant
effect
proliferation
migration
fibroblast.
Mechanistic
studies
revealed
inhibitory
activation
was
dependent
endoplasmic
reticulum
stress,
thereby
inhibiting
TGF-β/SMAD
signal
pathway.
Our
study
implied
hold
promise
approach
against
suppressing
activation.
safety
been
preliminary
model.
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7150 - 7150
Опубликована: Окт. 18, 2023
Phytochemicals
are
plant
secondary
metabolites
that
show
health
benefits
for
humans
due
to
their
bioactivity.
There
is
a
huge
variety
of
phytochemicals
have
already
been
identified,
and
these
compounds
can
act
as
antimicrobial
neuroprotection
agents.
Due
anti-microbial
activity
neuroprotection,
several
might
the
potency
be
used
natural
therapeutic
agents,
especially
Helicobacter
pylori
infection
neurodegenerative
disease,
which
become
global
concern
nowadays.
According
previous
research,
there
some
connections
between
H.
diseases,
Alzheimer's
disease.
Hence,
this
comprehensive
review
examines
different
kinds
from
sources
potential
agents
reduce
improve
An
additional
large-scale
study
needed
establish
connection
disease
how
could
condition.
