Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

Armeniacae semen amarum —seeds of Prunus armeniaca L. (Rosaceae) (ASA), also known as Kuxingren in Chinese, is a traditional Chinese herbal drug commonly used for lung disease and intestinal disorders. It has long been to treat coughs asthma, well lubricate the colon reduce constipation. ASA refers dried ripe seed diverse species Rosaceae contains variety phytochemical components, including glycosides, organic acids, amino flavonoids, terpenes, phytosterols, phenylpropanoids, other components. Extensive data shows that exhibits various pharmacological activities, such anticancer activity, anti-oxidation, antimicrobial anti-inflammation, protection cardiovascular, neural, respiratory digestive systems, antidiabetic effects, liver kidney, activities. In clinical practice, can be single or combination with medicines, forming ASA-containing formulas, afflictions. However, it important consider potential adverse reactions pharmacokinetic properties during its use. Overall, bioactive diversified actions potent efficacies, promising merits in-depth study on functional mechanisms facilitate application.

Language: Английский

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Spectrum‐Effect Relationship Between Fingerprints and Anti‐Inflammatory and Antitussive Activities of Raw and Processed Mume Fructus Extracts

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(4)

Published: Feb. 21, 2025

ABSTRACT Mume Fructus (MF), a representative substance in the field of medicine‐food homology, has been extensively utilized clinical treatments and daily diets for its raw processed forms. This study aimed to establish spectrum‐effect relationship between ultra–high‐performance liquid chromatography coupled with quadrupole tandem time‐of‐flight mass spectrometry (UHPLC‐Q‐TOF‐MS/MS) fingerprints anti‐inflammatory antitussive activities MF extracts. In UHPLC‐Q‐TOF‐MS/MS fingerprints, total 21 common peaks were identified. Bioactivity assays demonstrated that extracts exhibited varying degrees effects. Subsequently, relevant pharmacologically active ingredients screened by grey relation analysis partial least squares regression. The results showed nine components associated effects, namely, citric acid, isochlorogenic acid B, A, C, fumaric gallic neochlorogenic chlorogenic ononin. Additionally, three linked activity: amygdalin, syringic succinic respectively. work developed model combining findings provide reference discovery bioactive contribute rationalization medications.

Language: Английский

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Zhichuanling injection improves bronchial asthma by attenuation airway inflammation and epithelia-mesenchymal transition

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 344, P. 119540 - 119540

Published: Feb. 26, 2025

Language: Английский

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Elucidating the Antiviral Effects of a Novel Compound Throat Anti-viral Through Metabolomics and Network Pharmacology: A Study on Infectious Bronchitis Virus in Poultry

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 104956 - 104956

Published: March 1, 2025

Infectious bronchitis virus (IBV) is a major pathogen that causes significant economic losses in the global poultry industry. Current vaccination strategies provide only partial protection, highlighting need for more effective prevention and treatment methods. This study aimed to develop novel compound throat anti-viral (CTA) from natural plants using data Traditional Chinese Medicine Inheritance System identification through liquid chromatography-mass spectrometry. CTA demonstrated substantial anti-IBV effects both vitro vivo studies. In vitro, significantly inhibited IBV multiplication alleviated pathological lesions chicken embryonic kidney cells, tracheal rings, embryos. vivo, seven-day with obtained much milder clinical signs, enhanced growth performance, better immune organ indices infected chickens. Additionally, reduced levels trachea lungs increased specific antibody titers. also maintained body homeostasis, exhibiting strong antioxidant anti-inflammatory properties mitigated respiratory tract damage. Metabolomics network pharmacology analyses, revealed CTA's antiviral are mediated FoxO signaling pathway. successfully developed an prescription database based on validated efficacy of comprehensive experiments. The findings elucidated mechanisms action, particularly pathway, highlighted its potential application as

Language: Английский

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Fufang Luohanguo Qingfei granules reduces influenza virus susceptibility via MAVS-dependent type I interferon antiviral signaling

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117780 - 117780

Published: Jan. 24, 2024

Language: Английский

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Mechanistic insights into targeting caspase‐3 activation and alveolar macrophage pyroptosis by Ephedra and bitter almond compounds for treating pediatric pneumonia via network pharmacology and bioinformatics

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(4)

Published: April 1, 2024

Abstract This study investigates the molecular mechanism of Ma Huang‐Ku Xing Ren, a traditional Chinese medicine formula, in treating pediatric pneumonia. The focus is on regulation caspase‐3 activation and reduction alveolar macrophage necrosis through network pharmacology bioinformatics analyses Ephedra bitter almond components. Active compounds targets from ephedrine were obtained using TCMSP, TCMID, GeneCards databases, identifying pneumonia‐related genes. A protein–protein interaction (PPI) was constructed, core screened. GO KEGG pathway enrichment identified relevant genes pathways. An acute pneumonia mouse model created lipopolysaccharide (LPS) inhalation method, with overexpression induced by lentivirus. mice treated gastric lavage. Lung tissue damage, inflammatory markers (IL‐18 IL‐1β), cell death‐related gene assessed H&E staining, ELISA, western blot, flow cytometry, immunofluorescence. 128 active 121 almond. PPI revealed 13 proteins, analysis indicated involvement inflammation, apoptosis, necrosis, particularly pathway. In vivo results showed that treatment significantly mitigated LPS‐induced lung injury mice, reducing scores marker levels. It also decreased activity death macrophages. conclusion, ingredients targeting caspase‐3, may effectively treat apoptosis macrophages, as demonstrated both pharmacology, analyses, experimental data.

Language: Английский

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Apricot seeds: a unique feedstock for biodiesel and other applications

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 215 - 248

Published: Jan. 1, 2024

Language: Английский

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Prospective proof-of-concept observational RESEarch about traditional herbal preparation Treatment for Chronic Obstructive Pulmonary Disease (RESET-COPD-1)

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 26, 2024

Background Despite advances in medical science, chronic obstructive pulmonary disease (COPD) continues to impact patients’ lives significantly, due symptom management limitations. Cheongsangboha-tang (CSBHT; Qing Shang Bu Xia Tang) and Hyunggaeyeongyo-tang (HGYGT; Jing Jie Lian Qiao have been used treat respiratory diseases, including COPD. However, clinical data supporting their efficacy are lacking. We prospectively observed the response of patients with COPD CSBHT HGYGT as adjunctive therapies assessed feasibility future research. Methods Patients who were prescribed or according practice protocol Kyung Hee University Korean Medicine Hospital recruited. Participants visited hospital every month, for 6 months, receive herbal preparations a doctor’s diagnosis prescription outcome evaluations. The primary was 6-min walking test (6-MWT). Secondary outcomes included function (PFT), Assessment Test (CAT), St. George’s Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) score. Syndrome differentiation, adverse events, patient adherence recorded. Results Thirty-seven initially enrolled followed up mean period 154.1 days. 36 patients, while one received either HGYGT, both, throughout entire period. During preparation treatment period, no statistically significant changes 6-MWT. CAT score (mean ± standard deviation) changed from 17.0 5.0 12.5 3.6, visual analogue scale dyspnea 47.5 18.9 28.4 18.6 (both visit 5). coronavirus 2019 pandemic precluded PFT. SGRQ mMRC scores did not change significantly. study seven dropped out, two experienced mild dyspepsia, headache. No serious effects observed. Conclusion illustrated therapeutic potential provided preliminary on its safety Our highlights need derive optimal formulations, which should be administered an appropriate duration, based goals

Language: Английский

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Effectiveness of kumquat decoction for the improvement of cough caused by SARS-CoV-2 Omicron variants, a multicentre, prospective observational study

Phytomedicine, Journal Year: 2023, Volume and Issue: 120, P. 155008 - 155008

Published: Aug. 11, 2023

Kumquat decoction is a traditional Chinese medicine formula and has been widely used to alleviate the coronavirus disease 2019 (COVID-19)-related cough in China. However, effectiveness safety of kumquat remain unclear. To assess for COVID-19-related cough. A multicentre, prospective observational study. We enrolled consecutive patients with mild-to-moderate COVID-19 from December 31, 2022, January 3, 2023, during Omicron phase Yangshuo County, The primary outcome was time study baseline sustained resolution by last follow-up day on 2023. evaluated Cox proportional hazards models based propensity score analyses. secondary outcomes were other symptoms Days 5, 7. Of 1434 patients, 671 excluded analysis resolution. Among remaining 763 481 (63.04%) received decoction, 282 (36.96%) usual care. median age 38.0 (interquartile range [IQR] 29.0, 50.0) years, 55.7% women. During 7.000 days, 68.2% group achieved (93.77 per 1000 person-days) compared 39.7% care (72.94 person-days). differences restricted mean survival (RMST) (kumquat minus group) -0.742 days (95% CI, -1.235 -0.250, P = 0.003) Day In main using propensity-score matching, adjusted hazard ratio (HR) vs. 1.94 1.48 2.53, < 0.001). Similar findings found multiple sensitivity addition, use associated cough, stuffy nose 5 7, as well sore throat 7 following medication. this among receiving an earlier symptoms.

Language: Английский

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TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7126 - 7126

Published: Oct. 17, 2023

The limitations of current medications for treating rheumatoid arthritis (RA) emphasize the urgent need development new drugs. This study aimed to investigate potential anti-RA mechanism amygdalin using tandem mass tag (TMT)-based quantitative proteomics technology. First, activity was evaluated in a Complete Freund’s adjuvant (CFA)-induced rat model. Then, roles and importance proteins extracted joint tissue were TMT-based A bioinformatics analysis used analyze differentially abundant (DAPs). identified 297 DAPs group compared with model group, which 53 upregulated 51 downregulated showed opposite regulatory trends produced after modeling. According enrichment analyses DAPs, signaling pathways high correlation degree determined be complement coagulation cascades. Furthermore, western blotting molecular docking further validate key node proteins, e.g., C1s subcomponent (C1s), component C3 (C3) kininogen 1 (Kng1). These results suggest that may promising agent RA by regulating

Language: Английский

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