Blocking
the
interaction
of
SARS-CoV-2
spike
protein
with
human
angiotensin-converting
enzyme
II
(hACE2)
serves
as
a
therapeutic
strategy
for
treating
COVID-19.
Traditional
Chinese
medicine
(TCM)
treatments
containing
bioactive
products
could
alleviate
symptoms
severe
However,
emergence
variants
has
complicated
process
developing
broad-spectrum
drugs.
As
such,
aim
in
this
study
was
to
explore
efficacy
TCM
through
targeting
viral
hACE2
receptor.
The
antiviral
activity
systematically
evaluated
using
pseudovirus
system.
Scutellaria
baicalensis
found
be
effective
against
infection
affecting
protein.
active
molecules
S.
were
identified
and
analyzed.
Baicalein
baicalin,
flavone
glycoside,
respectively,
baicalensis,
exhibited
strong
inhibitory
activities,
or
protein,
respectively.
Under
optimized
conditions,
virus
inhibited
by
98%
via
baicalein-treated
baicalin-treated
hACE2.
In
summary,
we
potential
inhibitors
Omicron
receptor
from
baicalensis.
Future
studies
on
application
baicalein
baicalin
are
needed.
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
323, P. 117685 - 117685
Published: Jan. 1, 2024
Placenta
is
a
kind
of
traditional
Chinese
medicine,
known
as
"Ziheche",
which
has
the
function
tonifying
qi
and
blood,
nourishing
liver
kidney.
extract
(PE)
been
used
for
delaying
organismal
aging
treating
various
diseases.
Cow
placenta
rich
natural
resource
with
large
mass.
Its
composition
similar
to
that
human
placenta,
but
it
not
effectively
utilized.
However,
little
about
effect
CPE
on
mice.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 20, 2025
Liver
disease
is
a
significant
global
health
issue,
responsible
for
millions
of
deaths
annually.
Aging,
characterized
by
the
gradual
decline
in
cellular
and
physiological
functions,
impairs
tissue
regeneration,
increases
susceptibility
to
liver
diseases,
leads
health.
Silent
information
regulator
1
(SIRT1),
NAD⁺-dependent
deacetylase,
has
emerged
as
pivotal
factor
modulating
age-related
changes
liver.
SIRT1
preserves
function
regulating
essential
aging-related
pathways,
including
telomere
maintenance,
epigenetic
modifications,
senescence,
intercellular
communication,
inflammation,
mitochondrial
function.
Notably,
levels
naturally
with
age,
contributing
progression
increased
vulnerability
injury.
This
review
summarizes
regulatory
role
aging
its
impact
on
diseases
such
fibrosis,
alcoholic
associated
(ALD),
metabolic
dysfunction-associated
steatotic
(MASLD),
steatohepatitis
(MASH),
hepatocellular
carcinoma
(HCC).
We
also
discuss
emerging
therapeutic
approaches,
activators,
gene
therapy,
nutritional
interventions,
which
are
evaluated
their
potential
restore
mitigate
progression.
Finally,
we
highlight
future
research
directions
optimize
SIRT1-targeted
therapies
clinical
applications
conditions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2935 - 2935
Published: March 2, 2024
Blocking
the
interaction
between
SARS-CoV-2
spike
protein
and
human
angiotensin-converting
enzyme
II
(hACE2)
serves
as
a
therapeutic
strategy
for
treating
COVID-19.
Traditional
Chinese
medicine
(TCM)
treatments
containing
bioactive
products
could
alleviate
symptoms
of
severe
However,
emergence
variants
has
complicated
process
developing
broad-spectrum
drugs.
As
such,
aim
this
study
was
to
explore
efficacy
TCM
against
through
targeting
viral
with
hACE2
receptor.
Antiviral
activity
systematically
evaluated
using
pseudovirus
system.
Scutellaria
baicalensis
(S.
baicalensis)
found
be
effective
infection,
it
mediated
protein.
Moreover,
active
molecules
S.
were
identified
analyzed.
Baicalein
baicalin,
flavone
glycoside
in
baicalensis,
respectively,
exhibited
strong
inhibitory
activities
protein,
respectively.
Under
optimized
conditions,
virus
infection
inhibited
by
98%
via
baicalein-treated
baicalin-treated
hACE2.
In
summary,
we
potential
inhibitors
from
that
mediate
Omicron
Future
studies
on
application
baicalein
baicalin
are
needed.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 325 - 325
Published: Jan. 17, 2025
Background/Objectives:
A
fucoidan
oligosaccharide
(FOS),
a
potent
compound
derived
from
algae,
is
known
for
its
diverse
biological
activities,
including
prebiotic
activity,
anticancer
and
antioxidative
properties,
has
demonstrated
supportive
therapeutic
effects
in
treating
kidney
ailments.
This
study
was
conducted
to
explore
the
protective
influence
of
FOS
on
damage
due
aging
induced
by
D-galactose
Sprague
Dawley
(SD)
rats.
Methods:
The
low-dose
group
administered
(100
mg/kg)
gavage,
high-FOS
received
(200
gavage.
Results:
findings
showed
that
could
effectively
mitigate
improve
pathological
condition
tissues
caused
D-gal
enhance
function.
Intervention
with
significantly
reduced
serum
creatinine,
uric
acid,
urea
nitrogen
levels,
compared
model
group.
mechanism
D-gal-induced
injury
may
be
inhibit
oxidative
stress
impaired
mitochondrial
function
downregulating
AMPK/ULK1
signaling
pathway.
also
modulate
expression
autophagy-related
proteins
(Beclin-1,
P62,
LC3II/LC3I),
thereby
excessive
mitophagy
kidney.
Furthermore,
protect
against
preserving
intestinal
homeostasis.
decreased
lipopolysaccharide
levels
enhanced
mucosal
barrier
upregulated
abundances
Bacteroidota,
Muribaculaceae,
Lactobacillus,
while
it
Firmicutes,
NK4A136_group,
Lachnospiraceae_NK4A136_group.
supplementation
modulated
gut
microbiota
composition,
increasing
beneficial
bacteria
reducing
detrimental
ones,
potentially
contributing
improved
Conclusions:
safeguard
renal
D-gal-exposed
rats
inhibiting
mitophagy,
function,
regulating
Clinical Interventions in Aging,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 681 - 693
Published: May 1, 2024
Aging
and
aging-related
diseases
present
a
global
public
health
problem.
Therefore,
the
development
of
efficient
anti-aging
drugs
has
become
an
important
area
research.
Traditional
Chinese
medicine
is
complementary
alternative
branch
therapy.
Recently,
growing
number
studies
have
revealed
that
traditional
certain
delaying
effect
on
progression
aging
diseases.
Here,
we
review
progress
in
research
into
using
for
(including
neurodegenerative
diseases,
cardiovascular
diabetes,
cancer).
Furthermore,
summarize
potential
mechanisms
action
provide
references
further
The American Journal of Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 30
Published: Jan. 29, 2025
Oxidative
stress
represents
a
pivotal
mechanism
in
the
pathogenesis
of
numerous
chronic
diseases.
The
Kelch-like
ECH-associated
protein
1–transcription
factor
NF-E2
p45-related
2
(KEAP1–NRF2)
pathway
plays
crucial
role
maintaining
redox
homeostasis
and
regulating
multitude
biological
processes
such
as
inflammation,
homeostasis,
metabolic
homeostasis.
In
this
paper,
we
present
findings
recent
studies
on
KEAP1–NRF2
pathway,
which
have
revealed
that
it
is
aberrantly
regulated
induces
oxidative
injury
variety
diseases
neurodegenerative
diseases,
cardiovascular
respiratory
digestive
cancer.
Given
evidence,
targeting
highly
promising
avenue
for
developing
therapeutic
strategies
thus
development
appropriate
based
NRF2
has
emerged
significant
area
research
interest.
This
paper
highlights
an
overview
current
to
modulate
KEAP1–NRF2,
well
advances
use
natural
compounds
traditional
Chinese
medicine,
with
view
providing
meaningful
guidelines
drug
discovery
KEAP1–NRF2.
Additionally,
discusses
challenges
associated
harnessing
target.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1738 - 1738
Published: Feb. 18, 2025
Over
400
articles
on
the
pathophysiology
of
brain
aging,
neuroaging,
and
neurodegeneration
were
reviewed,
with
a
focus
epigenetic
mechanisms
numerous
non-coding
RNAs.
In
particular,
this
review
accent
is
microRNAs,
discovery
whose
pivotal
role
in
gene
regulation
was
recognized
by
2024
Nobel
Prize
Physiology
or
Medicine.
Aging
not
gradual
process
that
can
be
easily
modeled
described.
Instead,
multiple
temporal
processes
occur
during
they
lead
to
mosaic
changes
are
uniform
pace.
The
rate
change
depends
combination
external
internal
factors
boosted
accelerated
aging.
decrease
decelerated
aging
due
individual
structural
functional
reserves
created
cognitive,
physical
training,
pharmacological
interventions.
Neuroaging
caused
genetic
changes,
modifications,
oxidative
stress,
inflammation,
lifestyle,
environmental
factors,
which
especially
noticeable
space
environments
where
adaptive
trigger
aging-like
processes.
Numerous
candidate
molecular
biomarkers
specific
neuroaging
need
validated
develop
diagnostics
countermeasures.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2626 - 2626
Published: March 14, 2025
Aucubin
(AU)
is
one
of
the
main
components
traditional
Chinese
medicine
Eucommia
ulmoides
Oliv
(EU).
This
study
investigated
effects
AU
on
aging-related
skeletal
muscle
atrophy
in
vitro
and
vivo.
The
results
network
pharmacology
revealed
potential
therapeutic
atrophy.
In
vitro,
effectively
attenuated
D-gal-induced
cellular
damage,
reduced
number
senescence-associated
β-galactosidase
(SA-β-Gal)-positive
cells,
down-regulated
expression
levels
atrophy-related
proteins
Atrogin-1
MuRF1,
improved
myotube
differentiation,
thereby
mitigating
Notably,
was
found
to
attenuate
oxidative
stress
apoptosis
cells
by
reducing
ROS
production,
regulating
Cleaved
caspase3
BAX/Bcl-2
apoptotic
pathways,
enhancing
Sirt1
PGC-1α
signaling
pathways.
vivo
studies
demonstrated
that
treatment
extended
average
lifespan
Caenorhabditis
elegans
(C.
elegans),
increased
locomotor
activity,
body
wall
mitochondrial
content,
alleviated
damage
C.
elegans.
These
findings
suggested
can
ameliorate
show
significant
preventing
treating
